| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Turnay, N Olmo, M A Lizarbe, K von der Mar. Changes in the expression of annexin A5 gene during in vitro chondrocyte differentiation: influence of cell attachment. Journal of cellular biochemistry vol 84 issue 1 2002 11746522 |
the downregulation of annexin a5 expression in cells growing as matrix-rich aggregates was reverted when extracellular matrix components were removed and cells were reseeded onto tissue culture plastic, suggesting that cell spreading, formation of focal contacts and stress fibers stimulated annexin a5 expression in proliferating as well as in hypertrophic chondrocytes. |
2002-03-13 |
2023-01-24 |
chicken |
| Emiko Ogawa, Yoshihiko Saito, Koichiro Kuwahara, Masaki Harada, Yoshihiro Miyamoto, Ichiro Hamanaka, Noboru Kajiyama, Nobuki Takahashi, Takehiko Izumi, Rika Kawakami, Ichiro Kishimoto, Yoshihisa Naruse, Nozomu Mori, Kazuwa Naka. Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression. Cardiovascular research vol 53 issue 2 2002 11827696 |
brain natriuretic peptide (bnp) is a cardiac hormone mainly synthesized in ventricles and its expression is markedly increased in ventricular hypertrophy that involves the accumulation of extracellular matrix proteins, such as fibronectin (fn). |
2002-03-11 |
2023-01-24 |
Not clear |
| T K Jeffery, J C Wanstal. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacology & therapeutics vol 92 issue 1 2002 11750034 |
it involves thickening of all three layers of the blood vessel wall (due to hypertrophy and/or hyperplasia of the predominant cell type within each layer), as well as extracellular matrix deposition. |
2002-03-04 |
2023-01-24 |
Not clear |
| Sujata G Pandit, Prasanthi Govindraj, Joachim Sasse, Peter J Neame, John R Hassel. The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs. The Biochemical journal vol 361 issue Pt 2 2002 11772395 |
immunostaining localized fgfr3 to the pericellular region of reserve chondrocytes and to the extracellular matrix in the hypertrophic zone. |
2002-02-14 |
2023-01-24 |
human |
| Sujata G Pandit, Prasanthi Govindraj, Joachim Sasse, Peter J Neame, John R Hassel. The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs. The Biochemical journal vol 361 issue Pt 2 2002 11772395 |
these results suggest that the transmembrane form of fgfr3 increasingly undergoes proteolytic cleavage towards the hypertrophic zone to produce an extracellular-domain fragment of fgfr3, which is present in large amounts in the matrix of hypertrophic cells. |
2002-02-14 |
2023-01-24 |
human |
| Y Ogawa, N Tamura, H Chusho, K Naka. Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart. Canadian journal of physiology and pharmacology vol 79 issue 8 2002 11558681 |
in addition to cardiac myocyte hypertrophy, proliferation and increased extracellular matrix production of cardiac fibroblasts occur in response to cardiac overload. |
2002-02-07 |
2023-01-24 |
mouse |
| S Beavan, A Horner, S Bord, D Ireland, J Compsto. Colocalization of glucocorticoid and mineralocorticoid receptors in human bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 16 issue 8 2002 11499872 |
in the neonatal rib cartilage, staining for gralpha, gralphabeta, and mr was present in approximately one-half of the resting and hypertrophic chondrocytes and in most of proliferating chondrocytes and chondrocytes within the mineralizing matrix. |
2002-01-30 |
2023-01-24 |
human |
| S L Felisbino, H F Carvalh. Growth cartilage calcification and formation of bone trabeculae are late and dissociated events in the endochondral ossification of Rana catesbeiana. Cell and tissue research vol 306 issue 2 2002 11702243 |
in stage-46 tadpoles and 1-year-old animals, the hypertrophic cartilage had a smooth contact with the bone marrow and the matrix showed no calcification or endochondral bone formation. |
2002-01-22 |
2023-01-24 |
Not clear |
| S L Felisbino, H F Carvalh. Growth cartilage calcification and formation of bone trabeculae are late and dissociated events in the endochondral ossification of Rana catesbeiana. Cell and tissue research vol 306 issue 2 2002 11702243 |
calcium deposits appeared as isolated or coalesced spherical structures in the extracellular matrix of hypertrophic cartilage. |
2002-01-22 |
2023-01-24 |
Not clear |
| A Schubert, T Walther, V Falk, C Binner, N L\\xc3\\xb6scher, A Kanev, S Bleiziffer, T Rauch, R Autschbach, F W Moh. Extracellular matrix gene expression correlates to left ventricular mass index after surgical induction of left ventricular hypertrophy. Basic research in cardiology vol 96 issue 4 2002 11518194 |
extracellular matrix gene expression correlates to left ventricular mass index after surgical induction of left ventricular hypertrophy. |
2002-01-11 |
2023-01-24 |
Not clear |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure vol 23 issue 3-4 2001 11499562 |
prominent among these is transforming growth factor-beta (tgf-beta) because it promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. |
2001-12-28 |
2023-01-24 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure vol 23 issue 3-4 2001 11499562 |
neutralizing anti-tgf-beta antibodies prevent the hypertrophic and matrix stimulatory effects of high glucose in these cells. |
2001-12-28 |
2023-01-24 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure vol 23 issue 3-4 2001 11499562 |
we demonstrate that short-term treatment of diabetic mice with neutralizing monoclonal antibodies against tgf-beta significantly reduces kidney weight and glomerular hypertrophy and attenuates the increase in extracellular matrix mrnas. |
2001-12-28 |
2023-01-24 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure vol 23 issue 3-4 2001 11499562 |
the data we review here strongly support the hypothesis that elevated production or activity of the tgf-beta system mediates diabetic renal hypertrophy and extracellular matrix expansion. |
2001-12-28 |
2023-01-24 |
mouse |
| O Jacenko, D Chan, A Franklin, S Ito, C B Underhill, J F Bateman, M R Campbel. A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. The American journal of pathology vol 159 issue 6 2001 11733375 |
a dominant interference collagen x mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. |
2001-12-18 |
2023-01-24 |
mouse |
| O Jacenko, D Chan, A Franklin, S Ito, C B Underhill, J F Bateman, M R Campbel. A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. The American journal of pathology vol 159 issue 6 2001 11733375 |
electron microscopy revealed a disrupted hexagonal lattice network in the hypertrophic chondrocyte pericellular matrix in tg growth plates, as well as altered mineral deposition. |
2001-12-18 |
2023-01-24 |
mouse |
| S Goldfarb, F N Ziyade. TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy. Transactions of the American Clinical and Climatological Association vol 112 issue 2001 11413780 |
increased tgf-beta expression in the kidney in diabetes mellitus mediates the renal actions of high ambient glucose to promote cellular hypertrophy and stimulate extracellular matrix biosynthesis. |
2001-12-07 |
2023-01-24 |
mouse |
| F Zannad, B Dousset, F All. Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship. Hypertension (Dallas, Tex. : 1979) vol 38 issue 5 2001 11711528 |
cardiac extracellular matrix undergoes extensive and continuous turnover involved in the lesion-reparation process, such as in cardiac remodeling, in hypertensive cardiac hypertrophy, in dilated cardiomyopathy, after myocardial infarction in the transition to heart failure, and during the progression of left ventricular dysfunction. |
2001-12-07 |
2023-01-24 |
Not clear |
| J L Gooch, Y Tang, J M Ricono, H E Abbou. Insulin-like growth factor-I induces renal cell hypertrophy via a calcineurin-dependent mechanism. The Journal of biological chemistry vol 276 issue 45 2001 11509557 |
igf-i induced hypertrophy as determined by an increase in cell size and an increase in protein to dna ratio and increased accumulation of extracellular matrix (ecm) proteins. |
2001-12-05 |
2023-01-24 |
Not clear |
| T Nakase, T Miyaji, K Kuriyama, N Tamai, M Horiki, T Tomita, A Myoui, K Shimada, H Yoshikaw. Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human. Histochemistry and cell biology vol 116 issue 3 2001 11685558 |
pthrp, ihh, and ptc were immunolocalized in prehypertrophic and hypertrophic chondrocytes in mature cartilage matrix. |
2001-12-05 |
2023-01-24 |
human |