| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Ashizawa, K Graf, Y S Do, T Nunohiro, C M Giachelli, W P Meehan, T L Tuan, W A Hsue. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. The Journal of clinical investigation. vol 98. issue 10. 1997-01-23. PMID:8941637. |
angiotensin ii (aii) is a critical factor in cardiac remodeling which involves hypertrophy, fibroblast proliferation, and extracellular matrix production. |
1997-01-23 |
2023-08-12 |
rat |
| H Claassen, T Kirsch, G Simon. Cartilage canals in human thyroid cartilage characterized by immunolocalization of collagen types I, II, pro-III, IV and X. Anatomy and embryology. vol 194. issue 2. 1997-01-16. PMID:8827323. |
the extracellular matrix of hypertrophic chondrocytes adjacent to cartilage canals showed strong immunoreactivity for type x collagen. |
1997-01-16 |
2023-08-12 |
human |
| P W Anderson, X Y Zhang, J Tian, J D Correale, X P Xi, D Yang, K Graf, R E Law, W A Hsue. Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney international. vol 50. issue 3. 1997-01-06. PMID:8872947. |
angiotensin ii (ang ii) and insulin are implicated in the mesangial cell hypertrophy and excessive accumulation of mesangial matrix seen in glomerulosclerosis. |
1997-01-06 |
2023-08-12 |
rat |
| A L Bronckers, W Goei, G Luo, G Karsenty, R N D'Souza, D M Lyaruu, E H Burge. DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 9. 1996-12-26. PMID:8864903. |
we conclude that some of the osteocytes in deeper layers of bone die within their lacuna and disperse nuclear fragments over the extracellular matrix, that a majority of the osteocytes are phagocytosed and degraded by osteoclasts at sites of intense bone resorption, and that during endochondral ossification, substantial numbers of late hypertrophic chondrocyte cells undergo cell death. |
1996-12-26 |
2023-08-12 |
mouse |
| K Lee, B Lanske, A C Karaplis, J D Deeds, H Kohno, R A Nissenson, H M Kronenberg, G V Segr. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895385. |
terminal differentiation of chondrocytes, which was characterized by cell hypertrophy, apoptosis (dna fragmentation and decreased bcl-2 mrna expression), and matrix mineralization, was more advanced in growth cartilage of pthrp(-/-), compared with pthrp(+/+) animals. |
1996-12-17 |
2023-08-12 |
mouse |
| J Sesin, J Tamarg. [Effect of cilazapril, a converting enzyme inhibitor, on cardiovascular hypertrophy in the hypertensive patient]. Medicina. vol 56. issue 1. 1996-12-10. PMID:8734937. |
this is the result of a vascular tone increase and/or structural changes which imply hypertrophy as well as hyperplasia of the vascular smooth muscle fibers, hypertrophy of the cardiac cells and an increase in the constituent synthesis of the extracellular matrix. |
1996-12-10 |
2023-08-12 |
Not clear |
| P Pavasant, T Shizari, C B Underhil. Hyaluronan contributes to the enlargement of hypertrophic lacunae in the growth plate. Journal of cell science. vol 109 ( Pt 2). 1996-12-05. PMID:8838656. |
since hyaluronan can adsorb large amounts of water, it is possible that it exerted a hydrostatic pressure on the surrounding territorial matrix and thereby caused the expansion of hypertrophic lacunae. |
1996-12-05 |
2023-08-12 |
Not clear |
| E H Morrison, M W Ferguson, M T Bayliss, C W Arche. The development of articular cartilage: I. The spatial and temporal patterns of collagen types. Journal of anatomy. vol 189 ( Pt 1). 1996-11-25. PMID:8771392. |
interestingly, generalised matrix immunopositivity was only retained in the hypertrophic cartilage of the secondary centre of ossification. |
1996-11-25 |
2023-08-12 |
Not clear |
| H Karam, D Heudes, P Bruneval, M F Gonzales, B M Löffler, M Clozel, J P Cloze. Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension (Dallas, Tex. : 1979). vol 28. issue 3. 1996-11-22. PMID:8794820. |
cardiac hypertrophy and fibrosis, aortic medial thickness, and extracellular matrix content were evaluated by quantitative morphometry. |
1996-11-22 |
2023-08-12 |
rat |
| A Morocutti, K A Earle, M Sethi, G Piras, K Pal, D Richards, P Rodemann, G Vibert. Premature senescence of skin fibroblasts from insulin-dependent diabetic patients with kidney disease. Kidney international. vol 50. issue 1. 1996-11-22. PMID:8807595. |
diabetic glomerulopathy develops in a subset only of patients with insulin-dependent diabetes (iddm) and early, in its course, is characterized by cell hypertrophy and by excessive extracellular matrix production. |
1996-11-22 |
2023-08-12 |
human |
| S Gomez, J M Lopez-Cepero, G Silvestrini, E Bonucc. Matrix vesicles and focal proteoglycan aggregates are the nucleation sites revealed by the lanthanum incubation method: a correlated study on the hypertrophic zone of the rat epiphyseal cartilage. Calcified tissue international. vol 58. issue 4. 1996-11-04. PMID:8661960. |
matrix vesicles and focal proteoglycan aggregates are the nucleation sites revealed by the lanthanum incubation method: a correlated study on the hypertrophic zone of the rat epiphyseal cartilage. |
1996-11-04 |
2023-08-12 |
rat |
| S Gomez, J M Lopez-Cepero, G Silvestrini, E Bonucc. Matrix vesicles and focal proteoglycan aggregates are the nucleation sites revealed by the lanthanum incubation method: a correlated study on the hypertrophic zone of the rat epiphyseal cartilage. Calcified tissue international. vol 58. issue 4. 1996-11-04. PMID:8661960. |
the dense matrix vesicles are a specific type of matrix vesicle with the intrinsic capacity of precipitating lap mineral, as soon as they originate from the hypertrophic chondrocytes. |
1996-11-04 |
2023-08-12 |
rat |
| S Gomez, J M Lopez-Cepero, G Silvestrini, E Bonucc. Matrix vesicles and focal proteoglycan aggregates are the nucleation sites revealed by the lanthanum incubation method: a correlated study on the hypertrophic zone of the rat epiphyseal cartilage. Calcified tissue international. vol 58. issue 4. 1996-11-04. PMID:8661960. |
the were in close connection with the light matrix vesicles in the upper hypertrophic zone, and were loaded with a variable quantity of lap irregular electron-dense deposits in the lower hypertrophic zone. |
1996-11-04 |
2023-08-12 |
rat |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
in serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. |
1996-10-25 |
2023-08-12 |
cattle |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
isolated prehypertrophic chondrocytes in high density culture undergo a process of cellular maturation whereby full expression of the hypertrophic phenotype is characterized first by type x collagen synthesis followed by matrix calcification. |
1996-10-25 |
2023-08-12 |
cattle |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
using this culture system, we compared the capacity of tri-iodothyronine (t3) with thyroxine (t4) to stimulate expression of the hypertrophic phenotype and matrix calcification in three (b, c, and d) maturationally distinct prehypertrophic chondrocyte subpopulations. |
1996-10-25 |
2023-08-12 |
cattle |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
in dulbecco's modified eagle's medium supplemented with insulin, transferrin, and selenium, both hormones (t3/t4) separately induced, in a dose-dependent manner, chondrocyte maturation to the hypertrophic phenotype characterized by increased type x collagen mrna and induction of protein synthesis of this molecule, together with increased alkaline phosphatase activity, and eventually calcification of the extracellular matrix. |
1996-10-25 |
2023-08-12 |
cattle |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
this study demonstrates that the most immature chondrocytes at the prehypertrophic stage are direct targets for t3 and t4 and, to a much a lesser degree, that either hormone is able to induce full chondrocyte hypertrophy from an early maturational stage leading to matrix calcification. |
1996-10-25 |
2023-08-12 |
cattle |
| M Alini, Y Kofsky, W Wu, I Pidoux, A R Pool. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 1. 1996-10-25. PMID:8770703. |
these studies also offer a new serum-free chemically defined medium containing t3 or t4 for the culture of defined prehypertrophic chondrocytes that supports matrix assembly, hypertrophic expression, followed by matrix calcification. |
1996-10-25 |
2023-08-12 |
cattle |
| S Younai, G Venters, S Vu, L Nichter, M E Nimni, T L Tua. Role of growth factors in scar contraction: an in vitro analysis. Annals of plastic surgery. vol 36. issue 5. 1996-10-23. PMID:8743660. |
the ability of fibroblasts isolated from lesions of hypertrophic scars, keloids, normal skin, or normal scars in contracting the provisional wound matrix (i.e., fibrin clot) was compared and analyzed. |
1996-10-23 |
2023-08-12 |
Not clear |