| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandra Sacre, Albert Jaxa-Chamiec, Caroline M R Low, Giselle Chamberlain, Cathy Tralau-Stewar. Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors. Frontiers in immunology. vol 10. 2020-08-24. PMID:31244825. |
to explore if engagement of 5-hydroxytryptamine (5-ht) receptors was required for the anti-inflammatory effect of the tetracyclic antidepressant mianserin, a series of structural derivatives were generated with the aim of reducing 5-ht receptor binding. |
2020-08-24 |
2023-08-13 |
human |
| Sandra Sacre, Albert Jaxa-Chamiec, Caroline M R Low, Giselle Chamberlain, Cathy Tralau-Stewar. Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors. Frontiers in immunology. vol 10. 2020-08-24. PMID:31244825. |
the lead compound demonstrated a significant loss in 5-ht receptor binding, as assessed by non-selective 5-ht binding of radiolabelled serotonin in rat cerebral cortex. |
2020-08-24 |
2023-08-13 |
human |
| Maria C Cartolano, Haley N Gancel, Joshua Lonthair, Chris M Wood, M Danielle McDonal. Pulsatile urea excretion in Gulf toadfish: the role of circulating serotonin and additional 5-HT receptor subtypes. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 189. issue 5. 2020-07-01. PMID:31317244. |
pulsatile urea excretion in gulf toadfish: the role of circulating serotonin and additional 5-ht receptor subtypes. |
2020-07-01 |
2023-08-13 |
Not clear |
| Elena Kondratskaya, Oleksandr Ievglevskyi, Mark Züchner, Athina Samara, Joel C Glover, Jean-Luc Boullan. Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury. Brain research. vol 1708. 2020-06-15. PMID:30521786. |
this increased serotonin sensitivity was correlated with post-injury changes in the expression of specific serotonin receptor transcripts, but not of dopamine receptor transcripts. |
2020-06-15 |
2023-08-13 |
mouse |
| Md Rajib Sharker, Zahid Parvez Sukhan, Soo Cheol Kim, Won Kyo Lee, Kang Hee Kh. Identification, characterization, and expression analysis of a serotonin receptor involved in the reproductive process of the Pacific abalone, Haliotis discus hannai. Molecular biology reports. vol 47. issue 1. 2020-06-12. PMID:31696430. |
serotonin receptor (5-ht) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. |
2020-06-12 |
2023-08-13 |
Not clear |
| Haruka Mori, Keita Ashida, Hisashi Shidara, Tatsuya Nikai, Kohji Hotta, Kotaro Ok. Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans. PloS one. vol 14. issue 12. 2020-04-06. PMID:31800640. |
we simultaneously measured the neural activity of the rid and behavior in worms with three conditions: mock animals, animals pre-exposed to 5-ht, and 5-ht receptor mod-1 mutants. |
2020-04-06 |
2023-08-13 |
caenorhabditis_elegans |
| Minako Ito, Kyoko Komai, Toshihiro Nakamura, Tanakorn Srirat, Akihiko Yoshimur. Tissue regulatory T cells and neural repair. International immunology. vol 31. issue 6. 2020-04-03. PMID:30893423. |
brain tregs resemble other tissue tregs in many ways but, unlike the other tissue tregs, brain tregs express neural-cell-specific genes such as the serotonin receptor (htr7) and respond to serotonin. |
2020-04-03 |
2023-08-13 |
mouse |
| Rong Xiong, Wei Zhao, Xi Chen, Tian Li, Haiyin Li, Yan Li, Wangshang Shen, Ping Che. Pharmacological characterization of the 5-HT1A receptor of Bombyx mori and its role in locomotion. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 231. 2020-04-02. PMID:30690153. |
the effects of serotonin are mediated through interactions of several 5-ht receptor types. |
2020-04-02 |
2023-08-13 |
Not clear |
| Ana M Lucas-Osma, Yaqing Li, Katie Murray, Shihao Lin, Sophie Black, Marilee J Stephens, Andrew H Ahn, C J Heckman, Keith K Fenrich, Karim Fouad, David J Bennet. 5-HT Journal of neurophysiology. vol 121. issue 5. 2020-02-26. PMID:30625007. |
in chronic spinal rats, numerous 5-ht receptor agonists, including zolmitriptan, methylergonovine, and 5-ht, inhibited the msr with a potency highly correlated to their binding affinity to 5-ht |
2020-02-26 |
2023-08-13 |
rat |
| Yuan-Qiang Wang, Wei-Wei Lin, Nan Wu, Si-Yi Wang, Mao-Zi Chen, Zhi-Hua Lin, Xiang-Qun Xie, Zhi-Wei Fen. Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis. Acta pharmacologica Sinica. vol 40. issue 9. 2020-02-05. PMID:30814658. |
however, due to a high sequence similarity/identity among 5-ht receptors and the unavailability of the 3d structure of the different 5-ht receptor, no report was available so far regarding the systematical comparison of the key and selective residues involved in the binding pocket, making it difficult to design subtype-selective serotonergic drugs. |
2020-02-05 |
2023-08-13 |
Not clear |
| Xin Wen, Xue Yu, Rong Huo, Qiu-Xin Yan, Di Wu, Yan Feng, Ying Li, Xun Sun, Xin-Yu Li, Jie Sun, Ke-Xin Li, Qing-Yuan Li, Li-Min Han, Xiao-Long Lu, Yang Liu, Weinian Shou, Bai-Yan L. Serotonin-Mediated Cardiac Analgesia via Ah-Type Baroreceptor Activation Contributes to Silent Angina and Asymptomatic Infarction. Neuroscience. vol 411. 2020-02-04. PMID:31153963. |
5-ht or a 5-ht receptor agonist was microinjected into the nodose ganglion to confirm the involvement of the afferent pathway of the baroreflex arc. |
2020-02-04 |
2023-08-13 |
rat |
| Guangchen Ji, Volker Neugebaue. Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT International journal of molecular sciences. vol 20. issue 18. 2020-02-04. PMID:31489921. |
contribution of corticotropin-releasing factor receptor 1 (crf1) to serotonin receptor 5-ht the amygdala plays a key role in emotional-affective aspects of pain and in pain modulation. |
2020-02-04 |
2023-08-13 |
Not clear |
| Nicky Staes, Chet C Sherwood, Hani Freeman, Sarah F Brosnan, Steven J Schapiro, William D Hopkins, Brenda J Bradle. Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees. Molecular biology and evolution. vol 36. issue 7. 2020-01-30. PMID:31045220. |
polymorphisms in genes coding for the serotonin receptor subtype 1a (htr1a), the serotonin transporter (slc6a4), and the serotonin degrading enzyme monoamine oxidase a (maoa) are associated with anxiety, impulsivity, and neurotic personality in humans. |
2020-01-30 |
2023-08-13 |
Not clear |
| Muhammad Adnan Bashir, Arif-Ullah Khan, Haroon Badshah, Edson Rodrigues-Filho, Zia Ud Din, Aslam Kha. Synthesis, characterization, molecular docking evaluation, antidepressant, and anti-Alzheimer effects of dibenzylidene ketone derivatives. Drug development research. vol 80. issue 5. 2020-01-27. PMID:30964563. |
both a1k1 and a2k2 showed high binding affinities against various proteins involved in depression and alzheimer's mechanisms like monoamine oxidase b, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta-amyloid targets. |
2020-01-27 |
2023-08-13 |
mouse |
| Myrina Boulais, Marina Demoy-Schneider, Sayyed Mohammad Hadi Alavi, Jacky Cosso. Spermatozoa motility in bivalves: Signaling, flagellar beating behavior, and energetics. Theriogenology. vol 136. 2020-01-20. PMID:31234053. |
serotonin (5-ht) induces hyper-motility in spermatozoa via a 5-ht receptor, suggesting a serotoninergic system in the male reproductive tract that might regulate sperm physiology. |
2020-01-20 |
2023-08-13 |
Not clear |
| Kevin Sean Murnan. Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder. Behavioural pharmacology. vol 30. issue 2 and 3-Spec Issue. 2020-01-06. PMID:30632995. |
the 2a subtype of serotonin receptors (5-ht2a receptor) is the major excitatory serotonin receptor in the brain and has been linked to the effects of drugs that produce profound sensory and cognitive changes. |
2020-01-06 |
2023-08-13 |
Not clear |
| Sandip Basak, Yvonne Gicheru, Abhijeet Kapoor, Megan L Mayer, Marta Filizola, Sudha Chakrapan. Molecular mechanism of setron-mediated inhibition of full-length 5-HT Nature communications. vol 10. issue 1. 2019-12-11. PMID:31324772. |
molecular mechanism of setron-mediated inhibition of full-length 5-ht serotonin receptor (5-ht |
2019-12-11 |
2023-08-13 |
Not clear |
| Ling-Ling Teng, Guan-Ling Lu, Lih-Chu Chiou, Wei-Sheng Lin, Ya-Yun Cheng, Tai-En Hsueh, Yi-Ching Huang, Nai-Hsuan Hwang, Jin-Wei Yeh, Ruey-Ming Liao, Shou-Zen Fan, Jui-Hung Yen, Tsai-Feng Fu, Ting-Fen Tsai, Ming-Shiang Wu, Pei-Yu Wan. Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement. PLoS biology. vol 17. issue 3. 2019-11-25. PMID:30883547. |
we have explored the molecular mechanism of dr-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (htr6) are crucial in mediating this process. |
2019-11-25 |
2023-08-13 |
Not clear |
| Winberg, Nilsso. Multiple high-affinity binding sites for The Journal of experimental biology. vol 199. issue Pt 11. 2019-11-20. PMID:9320352. |
the ability of a number of synthetic 5-ht receptor ligands to displace [3h]5-ht was studied. |
2019-11-20 |
2023-08-12 |
Not clear |
| Versen, Gokorsch, Fiedler, Schip. Monoamines and the isolated auricle of sepia officinalis: are there &bgr;-like receptors in the heart of a cephalopod? The Journal of experimental biology. vol 202 (Pt 9). 2019-11-20. PMID:10101106. |
it is assumed that the auricular serotonin (5-ht) receptor represents a 5-ht1-like subtype and is not identical to the ventricular 5-ht receptor. |
2019-11-20 |
2023-08-12 |
Not clear |