| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Stücker, E Laemmel, B Teisseire, E Vicau. Specific response of mouse tumor-feeding arterioles to stimulation by 5-HT1 agonists. International journal of radiation oncology, biology, physics. vol 37. issue 5. 1997-06-13. PMID:9169822. |
topical administration of 5 x 10(-5) m serotonin in the presence of 10(-4) m ketanserin (5-ht2 receptors inhibitor) induced arteriolar vasodilation in tia (+13%) and in the control arterioles (+19%), but induced constriction (-14%) in the tumor-feeding arterioles (tfa). |
1997-06-13 |
2023-08-12 |
mouse |
| M C Holmes, K L French, J R Seck. Dysregulation of diurnal rhythms of serotonin 5-HT2C and corticosteroid receptor gene expression in the hippocampus with food restriction and glucocorticoids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151722. |
the adverse effects of serotonergic (5-ht)2c receptor activation on mood and food intake, the antidepressant efficacy of 5-ht2 receptor antagonists, and the hyperphagia observed in 5-ht2c receptor knockout mice all suggest a key role for increased 5-ht2c receptor-mediated neurotransmission. |
1997-06-10 |
2023-08-12 |
mouse |
| L A Pini, G Vitale, M Sandrin. Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid. Pharmacology. vol 54. issue 2. 1997-06-04. PMID:9088041. |
asa significantly increased brain serotonin (5-ht) content and reduced the number of 5-ht2 receptors in cortical brain membranes 30 min after drug administration. |
1997-06-04 |
2023-08-12 |
Not clear |
| L A Pini, G Vitale, M Sandrin. Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid. Pharmacology. vol 54. issue 2. 1997-06-04. PMID:9088041. |
pretreatment with naloxone abolished the antinociceptive activity of both asa and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-ht concentration and the reduction in 5-ht2 receptors in cortical membranes induced by asa. |
1997-06-04 |
2023-08-12 |
Not clear |
| C Karlsson, G Bodelsson, M Bodelsson, M Stjernquis. 5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors. Human reproduction (Oxford, England). vol 12. issue 2. 1997-06-03. PMID:9070726. |
5-hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-ht2 receptors. |
1997-06-03 |
2023-08-12 |
human |
| C Karlsson, G Bodelsson, M Bodelsson, M Stjernquis. 5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors. Human reproduction (Oxford, England). vol 12. issue 2. 1997-06-03. PMID:9070726. |
the efficacy for different agonists rated: alpha-methyl-5-ht (5-ht2) = 5-ht (non-selective) = 2-methyl-5-ht (5-ht3) >> sumatriptan (5-ht1), and the potency as: sumatriptan = 5-ht > 5-ht > alpha-methyl-5-ht > 2-methyl-5-ht. |
1997-06-03 |
2023-08-12 |
human |
| C Karlsson, G Bodelsson, M Bodelsson, M Stjernquis. 5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors. Human reproduction (Oxford, England). vol 12. issue 2. 1997-06-03. PMID:9070726. |
the contractile effects of 5-ht and alpha-methyl-5-ht were antagonized by the 5-ht2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. |
1997-06-03 |
2023-08-12 |
human |
| C M Burns, H Chu, S M Rueter, L K Hutchinson, H Canton, E Sanders-Bush, R B Emeso. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature. vol 387. issue 6630. 1997-05-29. PMID:9153397. |
the 5-ht2 family of receptors belongs to a large group of seven-transmembrane-spanning g-protein-coupled receptors and includes three receptor subtypes (5-ht2a, 5-ht(2b) and 5-ht(2c)) which are linked to phospholipase c, promoting the hydrolysis of membrane phospholipids and a subsequent increase in the intracellular levels of inositol phosphates and diacylglycerol. |
1997-05-29 |
2023-08-12 |
Not clear |
| J C Callera, L G Bonagamba, C Sévoz, R Laguzzi, B H Machad. Cardiovascular effects of microinjection of low doses of serotonin into the NTS of unanesthetized rats. The American journal of physiology. vol 272. issue 4 Pt 2. 1997-05-28. PMID:9140012. |
however, since microinjection of 5-ht (1 pmol) into the nts produced no changes in the cardiovascular responses to the baro- and chemoreflex activated 1 min later, the role of 5-ht2 receptors in the processing of the cardiovascular afferent messages in the nts remains to be elucidated. |
1997-05-28 |
2023-08-12 |
rat |
| E A Pehe. Local infusion of the serotonin antagonists ritanserin or ICS 205,930 increases in vivo dopamine release in the rat medial prefrontal cortex. Synapse (New York, N.Y.). vol 24. issue 1. 1997-05-22. PMID:9046072. |
furthermore, 5-ht may normally inhibit cortical da release by actions at the 5-ht2 receptor subtype. |
1997-05-22 |
2023-08-12 |
rat |
| N H Prins, M R Briejer, J A Schuurke. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. British journal of pharmacology. vol 120. issue 4. 1997-05-22. PMID:9051313. |
the 5-ht1 and 5-ht2 receptor antagonist methysergide (0.1 microm) depressed the curve to 5-ht, but the selective 5-ht3 receptor antagonist granisetron (0.3 microm) had no effect. |
1997-05-22 |
2023-08-12 |
Not clear |
| N H Prins, M R Briejer, J A Schuurke. Characterization of the contraction to 5-HT in the canine colon longitudinal muscle. British journal of pharmacology. vol 120. issue 4. 1997-05-22. PMID:9051313. |
besides 5-ht, alpha-methyl-5-ht (alpha-me-5-ht), 5-methoxytryptamine (5-meot), 2-methyl-5-ht (2-me-5-ht) and 5-carboxamidotryptamine (5-ct) also induced contractions, with the following rank order of potency (pec50 values in parentheses): 5-ht (6.9) = alpha-methyl-5-ht (6.9) > 2-me-5-ht (5.8) = 5-meot (5.7) = 5-ct (5.6), indicative of 5-ht2 receptor involvement, alpha-me-5-ht produced a bell-shaped curve, which was not affected by alpha-adrenoceptor blockade. |
1997-05-22 |
2023-08-12 |
Not clear |
| H Kobayashi, Y Hasegawa, H On. Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. European journal of pharmacology. vol 311. issue 1. 1997-05-15. PMID:8884233. |
however, cyclobenzaprine inhibited monosynaptic reflex facilitation induced by (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane, a 5-ht2 receptor agonist, in spinalized rats markedly, and 5-ht depletion by dl-p-chlorophenylalanine inhibited the depressive effect of cyclobenzaprine on the monosynaptic reflex. |
1997-05-15 |
2023-08-12 |
rat |
| N Humblot, L Esteve, C Burgun, D Aunis, J Zwille. 5-Hydroxytryptamine induces TIS8/egr-1 and c-fos expression in PC12 cells. Involvement of tyrosine protein phosphorylation. The European journal of neuroscience. vol 9. issue 1. 1997-05-15. PMID:9042572. |
the 5-ht-induced activation in egr-1 binding was inhibited by ketanserin and mesulergine, indicating that 5-ht exerted its action via a 5-ht2 receptor subtype. |
1997-05-15 |
2023-08-12 |
rat |
| T Matsuoka, T Nishizaki, Y Ikeuchi, Y Okada, K Sumin. Differential effects of the serotonin receptors on cultured rat cerebral cortical neurons. Cellular and molecular life sciences : CMLS. vol 53. issue 3. 1997-05-06. PMID:9104486. |
in contrast, application of 5-ht or a 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope conductance of 140 ps (8/30 patches/neurons) or 135 ps (6/20 patches neurons), respectively. |
1997-05-06 |
2023-08-12 |
rat |
| S Eddahibi, B Raffestin, I Pham, J M Launay, P Aegerter, M Sitbon, S Adno. Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats. The American journal of physiology. vol 272. issue 3 Pt 2. 1997-04-28. PMID:9087590. |
in conscious rats, intravenous administration of 5-ht potentiated the pulmonary pressor response to acute hypoxia (10% o2, n = 5), an effect that remained unchanged after pretreatment with a 5-ht1 and a 5-ht2 antagonist (n = 4) but was attenuated after treatment with the cyclooxygenase inhibitor meclofenamate (n = 4). |
1997-04-28 |
2023-08-12 |
rat |
| C Sévoz, J C Callera, B H Machado, M Hamon, R Laguzz. Role of serotonin3 receptors in the nucleus tractus solitarii on the carotid chemoreflex. The American journal of physiology. vol 272. issue 3 Pt 2. 1997-04-28. PMID:9087599. |
in contrast, local microinjections of antagonists acting at 5-ht1 and 5-ht2 receptors, such as methysergide (100 pmol) and ketanserin (10 pmol), respectively, did not prevent the actions of 5-ht or cpbg. |
1997-04-28 |
2023-08-12 |
rat |
| M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain. Life sciences. vol 60. issue 16. 1997-04-25. PMID:9096260. |
streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-ht1a and 5-ht2 receptors in the rat brain. |
1997-04-25 |
2023-08-12 |
rat |
| M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain. Life sciences. vol 60. issue 16. 1997-04-25. PMID:9096260. |
since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-ht(1a) and 5-ht2 receptors in cerebral cortex and brainstem. |
1997-04-25 |
2023-08-12 |
rat |
| M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain. Life sciences. vol 60. issue 16. 1997-04-25. PMID:9096260. |
our data show that streptozotocin induces a longlasting hyperglicemia that is associated with a decrease in cerebral concentration of serotonin and with an accompanying increase in the maximum number of 5-ht(1a) and 5-ht2 receptors in the brain areas studied. |
1997-04-25 |
2023-08-12 |
rat |