| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Hansson, I Alafuzoff, B Winblad, J Marcusso. Intact brain serotonin system in vascular dementia. Dementia (Basel, Switzerland). vol 7. issue 4. 1997-01-30. PMID:8835882. |
the 5-ht uptake site was used as a presynaptic marker for 5-ht terminals and 5-ht1a and 5ht2 receptors were used as postsynaptic markers. |
1997-01-30 |
2023-08-12 |
Not clear |
| H Huddart, R B Hil. Modulatory mechanisms in the isolated internally perfused ventricle of the whelk Busycon canaliculatum. General pharmacology. vol 27. issue 5. 1997-01-30. PMID:8842683. |
metoclopramide was without affect on 5ht responses, but metitipine and methysergide did inhibit such responses suggesting that the 5ht receptor present possessed mixed properties of the vertebrate 5-ht1 and 5-ht2 receptor subtypes. |
1997-01-30 |
2023-08-12 |
Not clear |
| S Goto, T Egashira, Y Wada, F Takayama, Y Yamanak. Effect of fluvoxamine on 5-hydroxytryptamine uptake, paroxetine binding sites and ketanserin binding sites in the Japanese monkey brain and platelets, in vivo and in vitro. Japanese journal of pharmacology. vol 71. issue 4. 1997-01-30. PMID:8886926. |
on 5-ht uptake sites that bind 3h-paroxetine and 5-ht2 receptors that bind 3h-ketanserin, in monkey brains and platelets. |
1997-01-30 |
2023-08-12 |
monkey |
| D P van Kammen, J P McEvoy, S D Targum, D Kardatzke, T B Sebre. A randomized, controlled, dose-ranging trial of sertindole in patients with schizophrenia. Psychopharmacology. vol 124. issue 1-2. 1997-01-29. PMID:8935813. |
sertindole is a novel antipsychotic agent with high selectivity for the mesolimbic dopaminergic pathway and nanomolar affinities for dopamine d2, serotonin 5-ht2, and norepinephrine ne alpha 1 receptors. |
1997-01-29 |
2023-08-12 |
Not clear |
| P Jäkälä, M Björklund, P Riekkine. Suppression of neocortical high-voltage spindles by nicotinic acetylcholine and 5-HT2 receptor stimulation. European journal of pharmacology. vol 299. issue 1-3. 1997-01-23. PMID:8901007. |
to investigate the roles of the nicotinic acetylcholine receptor and the serotonin (5-hydroxytryptamine; 5-ht) subtype 2 receptor in the modulation of rat thalamocortical oscillations, the effects of systemic (s.c.) administration of nicotine, a nicotinic acetylcholine receptor agonist, and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), a 5-ht2 receptor agonist, on neocortical high-voltage spindle activity occurring during quiet waking-immobility behavior in aged (28 months of age) and adult (7 months of age) rats were studied. |
1997-01-23 |
2023-08-12 |
rat |
| J Khater-Boidin, D Rose, B Duro. Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens. The Journal of physiology. vol 495 ( Pt 1). 1997-01-15. PMID:8866368. |
in decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application of 5-ht (n = 16) or related agents (5-ht1a agonist, 8-oh-dpat (n = 6) and 5-ht2 agonist, doi floor of the ivth ventricle. |
1997-01-15 |
2023-08-12 |
Not clear |
| J Khater-Boidin, D Rose, B Duro. Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens. The Journal of physiology. vol 495 ( Pt 1). 1997-01-15. PMID:8866368. |
application of agonists showed that both the 5-ht-dependent modulation of fi and the effects of 5-ht on the activity of the muscles studied resulted predominantly from activation of 5-ht2 receptors. |
1997-01-15 |
2023-08-12 |
Not clear |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
it bound potently at serotonin 5-ht2, dopaminergic d2, serotonin 5-ht1a, and adrenergic alpha 1 and alpha 2 receptors. |
1997-01-15 |
2023-08-12 |
rat |
| L B Barradell, R N Brogde. Oral naftidrofuryl. A review of its pharmacology and therapeutic use in the management of peripheral occlusive arterial disease. Drugs & aging. vol 8. issue 4. 1997-01-13. PMID:8920176. |
as a serotonin 5-ht2 receptor antagonist, naftidrofuryl has vasoactive properties in addition to its favourable effects on oxidative metabolism, peripheral transcutaneous oxygen pressure and the rheological properties of platelets and erythrocytes. |
1997-01-13 |
2023-08-12 |
Not clear |
| T de Boe. The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. International clinical psychopharmacology. vol 10 Suppl 4. 1997-01-08. PMID:8930006. |
in addition, mirtazapine has a low affinity for serotonin (5-ht)1a receptors but potently blocks 5-ht2 and 5-ht3 receptors. |
1997-01-08 |
2023-08-12 |
Not clear |
| T de Boe. The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. International clinical psychopharmacology. vol 10 Suppl 4. 1997-01-08. PMID:8930006. |
the blockade of 5-ht2 and 5-ht3 receptors prevents development of the side effects associated with non-selective 5-ht activation and may contribute to the anxiolytic and sleep-improving properties of this new compound. |
1997-01-08 |
2023-08-12 |
Not clear |
| M H Norman, F Navas, J B Thompson, G C Rigdo. Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents. Journal of medicinal chemistry. vol 39. issue 24. 1997-01-06. PMID:8941382. |
these analogues were evaluated in vitro for their binding to the dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1997-01-06 |
2023-08-12 |
mouse |
| R Sandy. Estrogen's impact on cognitive functions in multiple sclerosis. The International journal of neuroscience. vol 86. issue 1-2. 1996-12-26. PMID:8828057. |
serotonin (5-ht) mechanisms have been implicated in memory functions and estrogens modulate these functions through an interaction with 5-ht2 receptors in the cerebral cortex and limbic system. |
1996-12-26 |
2023-08-12 |
Not clear |
| R Sandy. Estrogen's impact on cognitive functions in multiple sclerosis. The International journal of neuroscience. vol 86. issue 1-2. 1996-12-26. PMID:8828057. |
it is suggested that estrogen withdrawal induces impairment in cognitive functions through dysregulation of 5-ht2 receptor activity and 5-ht neurotransmission. |
1996-12-26 |
2023-08-12 |
Not clear |
| A J Fischman, A A Bonab, J W Babich, N M Alpert, S L Rauch, D R Elmaleh, T M Shoup, S A Williams, R H Rubi. Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone. The Journal of pharmacology and experimental therapeutics. vol 279. issue 2. 1996-12-24. PMID:8930203. |
ziprasidone is a novel antipsychotic agent, with high affinity for dopamine d2 and serotonin (5-ht2) receptors in vitro and in animal models. |
1996-12-24 |
2023-08-12 |
human |
| D Pawlak, J Malyszko, J S Malyszko, K Pawlak, W Buczko, M Mysliwie. Peripheral serotonergic system in uremia. Thrombosis research. vol 83. issue 2. 1996-12-18. PMID:8837318. |
following platelet activation upon a contact with a damaged vessel wall, 5-ht, released from platelets upon the activation of 5-ht2 receptors, may amplify the action of other agents on vascular smooth muscle cells and platelets (3,4). |
1996-12-18 |
2023-08-12 |
Not clear |
| M Yang, A Srikiatkhachorn, M Anthony, B H Chon. Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 7. issue 2. 1996-12-16. PMID:8735801. |
serotonin stimulates megakaryocytopoiesis via the 5-ht2 receptor. |
1996-12-16 |
2023-08-12 |
mouse |
| M Yang, A Srikiatkhachorn, M Anthony, B H Chon. Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 7. issue 2. 1996-12-16. PMID:8735801. |
the results show that: (a) serotonin significantly stimulates megakaryocyte colony formation with maximum stimulation at 100 nm; (b) enhanced action is found between serotonin and interleukin-3 (il-3), interleukin-6 (il-6), granulocyte macrophage-colony stimulating factor (gm-csf), erythropoietin (epo) and pdgf; (c) ketanserin, a 5-ht2 receptor antagonist, blocks the mitogenic effect of serotonin on megakaryocytopoiesis; and (d) meg-01 cells (a megakaryocyte cell line) express 5-ht2 receptors. |
1996-12-16 |
2023-08-12 |
mouse |
| M Yang, A Srikiatkhachorn, M Anthony, B H Chon. Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 7. issue 2. 1996-12-16. PMID:8735801. |
this study demonstrates that serotonin has a mitogenic effect on megakaryocytopoiesis and this effect may be mediated via the 5-ht2 receptor which is known to be coupled to g protein. |
1996-12-16 |
2023-08-12 |
mouse |
| C Ullmer, H G Boddeke, K Schmuck, H Lübber. 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882600. |
despite the lack of detectable inositol phosphate (ip) formation in human pulmonary artery endothelial cells, 5-ht (pd2 = 5.82 +/- 0.06, n = 6) or the selective 5-ht2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) (pd2 = 5.66 +/- 0.03, n = 7) elicited transient calcium signals comparable to those evoked by histamine (pd2 = 6.44 +/- 0.01, n = 7). |
1996-12-11 |
2023-08-12 |
human |