| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474032. |
haloperidol and ketanserin (5 mg/kg, i.p., 24 h before the experiment) were ineffective in blocking the responsiveness of ca3 pyramidal neurons to 5-ht, thereby demonstrating that the dopamine d2 and 5-ht2 properties of spiperone could not account for the attenuated responsiveness of the hippocampus neurons to 5-ht. |
1993-05-18 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474616. |
in guinea pig brainstem, the rank order of binding site density was: 5-ht transporter site >> 5-ht1d > antagonist-labeled 5-ht2 > 5-ht1a, 5-ht1c > 5-ht1e > agonist-labeled 5-ht2 binding site. |
1993-05-17 |
2023-08-12 |
rat |
| M R Pranzatelli, P T Tailor, P Raz. Brainstem serotonin receptors in the guinea pig: implications for myoclonus. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474616. |
there were fewer 5-ht1a and 5-ht1c binding sites and 5-ht uptake sites in guinea pig than rat brainstem, more 5-ht1d and antagonist-labeled 5-ht2 sites, but the differences were 2-fold or less. |
1993-05-17 |
2023-08-12 |
rat |
| M Iyo, T Yamasak. The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 3. 1993-05-17. PMID:8475323. |
the detection of age-related decrease of dopamine d1, d2 and serotonin 5-ht2 receptors in living human brain. |
1993-05-17 |
2023-08-12 |
human |
| M Iyo, T Yamasak. The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 3. 1993-05-17. PMID:8475323. |
using positron emission tomography and 11c-n-methylspiperone and 11c- sch23390, dopamine d1 and d2 receptors, and serotonin 5-ht2 receptors in human brain were evaluated in living healthy age different subjects. |
1993-05-17 |
2023-08-12 |
human |
| M Noguchi, T Nakane, S Chib. Characterization of 5-HT receptors in simian isolated gastroepiploic artery. European journal of pharmacology. vol 234. issue 1. 1993-05-14. PMID:8472752. |
from these results, we conclude that (1) the simian gastroepiploic artery contains 5-ht receptors, (2) 5-ht1-like and 5-ht2 receptors are involved in the vasoconstriction of the simian gastroepiploic artery, and (3) the vasoconstriction is at least partially related to the activation of calcium ion channels. |
1993-05-14 |
2023-08-12 |
Not clear |
| M T Martín, A G Fernández, E Fernández, E Goñalon. Receptors implicated in the actions of serotonin on chicken ileum longitudinal smooth muscle. Life sciences. vol 52. issue 16. 1993-05-03. PMID:8464335. |
5-methoxytryptamine (5-mot), a mixed 5-ht1, 5-ht2 and 5-ht4 agonist, reproduced all the effects of 5-ht. |
1993-05-03 |
2023-08-12 |
chicken |
| T W Lovenberg, M G Erlander, B M Baron, M Racke, A L Slone, B W Siegel, C M Craft, J E Burns, P E Danielson, J G Sutcliff. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 6. 1993-04-23. PMID:8384716. |
degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains iii, v, and vi of known receptors [5-ht1a, 5-ht1c, and 5-ht2; 5-ht is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions. |
1993-04-23 |
2023-08-12 |
human |
| J W Wei, S R Yeh, C L Chen. Characterization of 3H-serotonin (5-HT) binding and effects on the phosphoinositides (PI) turnover in cultured C6 glioma and N2 neuroblastoma cells from rodents. The Chinese journal of physiology. vol 35. issue 3. 1993-04-22. PMID:1338307. |
the ec50 values for 5-ht for this event were in the dose range between 0.5 to 1.5 microm, and this 5-ht-induced response could be blocked by 5-ht2 antagonist ketanserin more effectively than the 5-ht1 antagonist or 5-ht3 antagonist studied. |
1993-04-22 |
2023-08-11 |
Not clear |
| J W Wei, S R Yeh, C L Chen. Characterization of 3H-serotonin (5-HT) binding and effects on the phosphoinositides (PI) turnover in cultured C6 glioma and N2 neuroblastoma cells from rodents. The Chinese journal of physiology. vol 35. issue 3. 1993-04-22. PMID:1338307. |
our results indicate that the predominant receptor subtype of 5-ht in c6 and n2 cells are 5-ht2, and 5-ht3 respectively, and that the pi turnover is linked to 5-ht2, but not 5-ht3 receptor activation. |
1993-04-22 |
2023-08-11 |
Not clear |
| J L Szarek, J Z Zhang, C A Gruette. 5-HT2 receptors augment cholinergic nerve-mediated contraction of rat bronchi. European journal of pharmacology. vol 231. issue 3. 1993-04-15. PMID:8449226. |
however, ketanserin, mianserin and spiperone, 5-ht2 receptor antagonists, abolished the effects of 5-ht on efs-induced responses. |
1993-04-15 |
2023-08-12 |
rat |
| J L Szarek, J Z Zhang, C A Gruette. 5-HT2 receptors augment cholinergic nerve-mediated contraction of rat bronchi. European journal of pharmacology. vol 231. issue 3. 1993-04-15. PMID:8449226. |
these results are consistent with a role for 5-ht2 receptor activation in mediating the facilitatory effects of 5-ht on cholinergic nerve-mediated responses in airways. |
1993-04-15 |
2023-08-12 |
rat |
| S Rahman, R S Neuma. Activation of 5-HT2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. European journal of pharmacology. vol 231. issue 3. 1993-04-15. PMID:8449227. |
subnanomolar concentrations of methysergide, ritanserin and spiperone, but not ics 205-930, attenuated the 5-ht enhancement, compatible with 5-ht2, but not 5-ht1 or 5-ht3 receptor subtype involvement. |
1993-04-15 |
2023-08-12 |
rat |
| S Rahman, R S Neuma. Activation of 5-HT2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. European journal of pharmacology. vol 231. issue 3. 1993-04-15. PMID:8449227. |
we conclude that serotonin enhances n-methyl-d-aspartate depolarization of rat cortical neurons through activation of 5-ht2 receptors, however the cellular mechanism underlying the facilitation remains to be established. |
1993-04-15 |
2023-08-12 |
rat |
| J O Svartengre. Selective down-regulation of the agonist-dependent high affinity state of rat cortical 5-HT2 receptors following chronic treatment with amperozide. Journal of receptor research. vol 13. issue 1-4. 1993-04-15. PMID:8450497. |
amperozide, a putative antipsychotic drug, is a selective serotonin 5-ht2 receptor antagonist with moderate affinity for the rat brain dopamine d2 receptor. |
1993-04-15 |
2023-08-12 |
rat |
| C F Neely, D Haile, I Mato. Tone-dependent responses of 5-hydroxytryptamine in the feline pulmonary vascular bed are mediated by two different 5-hydroxytryptamine receptors. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450468. |
at low (resting) pv tone, intralobar injections of 5-ht produced dose-dependent vasoconstrictor (vc) responses which were significantly blocked by the selective 5-ht2 receptor antagonist ketanserin and enhanced by the cyclooxygenase inhibitor meclofenamate. |
1993-04-14 |
2023-08-12 |
Not clear |
| C F Neely, D Haile, I Mato. Tone-dependent responses of 5-hydroxytryptamine in the feline pulmonary vascular bed are mediated by two different 5-hydroxytryptamine receptors. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450468. |
at both low (resting) and elevated pv tone, 5-ht and the selective 5-ht2 receptor agonist alpha-methyl-5-ht produced greater vc responses than the selective 5-ht1 receptor agonist 5-carboxyaminotryptamine and the selective 5-ht3 receptor agonist 2-methyl-5-ht. |
1993-04-14 |
2023-08-12 |
Not clear |
| M J Millan, J M Rivet, H Canton, S Le Marouille-Girardon, A Gober. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450471. |
agonists at 5-ht1b, 5-ht1c, 5-ht2 and/or 5-ht3 receptors did not elicit hypothermia, and drugs releasing 5-ht elicited hyperthermia. |
1993-04-14 |
2023-08-12 |
rat |
| F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:7680751. |
within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-ht)] receptors: 5-ht2 > 5-ht1d > 5-ht1c > 5-ht1b > 5-ht1a > 5-ht1e. |
1993-04-13 |
2023-08-12 |
rat |
| J Akiyoshi, C Hough, D M Chuan. Paradoxical increase of 5-hydroxytryptamine2 receptors and 5-hydroxytryptamine2 receptor mRNA in cerebellar granule cells after persistent 5-hydroxytryptamine2 receptor stimulation. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:8383800. |
prestimulation of these neurons with 10 microm 5-ht or (+/-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane [(+/-)-doi], a putative 5-ht2 receptor agonist, resulted in a time-dependent desensitization of the phosphoinositide response to 5-ht. |
1993-04-13 |
2023-08-12 |
rat |