| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Akiyoshi, C Hough, D M Chuan. Paradoxical increase of 5-hydroxytryptamine2 receptors and 5-hydroxytryptamine2 receptor mRNA in cerebellar granule cells after persistent 5-hydroxytryptamine2 receptor stimulation. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:8383800. |
however, [3h]ketanserin binding to 5-ht2 receptors in crude membranes or intact cerebellar granule cells was increased by treatment with 5-ht or doi, in a time- and concentration-dependent manner. |
1993-04-13 |
2023-08-12 |
rat |
| J Akiyoshi, C Hough, D M Chuan. Paradoxical increase of 5-hydroxytryptamine2 receptors and 5-hydroxytryptamine2 receptor mRNA in cerebellar granule cells after persistent 5-hydroxytryptamine2 receptor stimulation. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:8383800. |
thus, an increase in 5-ht2 receptor mrna was detected within 2 hr after 5-ht or doi prestimulation, reached a maximum around 4 hr, and remained at a plateau for at least 24 hr. |
1993-04-13 |
2023-08-12 |
rat |
| M A Valdovinos, G M Thomforde, M Camiller. Effect of putative carcinoid mediators on gastric and small bowel transit in rats and the role of 5-HT receptors. Alimentary pharmacology & therapeutics. vol 7. issue 1. 1993-04-01. PMID:7679934. |
we conclude that circulating substance p is unlikely to be an important accelerator of transit through the upper digestive tract; in contrast, hyperserotoninaemia significantly accelerates transit through the stomach, and 5-ht2 and 5-ht3 receptor subtypes may play a role in the motor effects of serotonin in the stomach. |
1993-04-01 |
2023-08-12 |
rat |
| H Nishio, Y Ikegami, Y Nakata, T Segaw. Relationships between serotonin induced elevation of intracellular Ca2+ concentration and stimulation of Ca2+ influx in blood platelets. Neurochemistry international. vol 22. issue 2. 1993-04-01. PMID:8439773. |
at the same concentration 5-ht was also found to enhance ca2+ influx through the activation of 5-ht2 receptor, but with rather longer latent time. |
1993-04-01 |
2023-08-12 |
Not clear |
| K Endlich, R Kühn, M Steinhause. Visualization of serotonin effects on renal vessels of rats. Kidney international. vol 43. issue 2. 1993-04-01. PMID:8441228. |
we believe that 5-ht decreases gbf by 5-ht2 receptor-mediated constriction of the large renal vessels which are modulated by the prostaglandin system, whereas 5-ht dilates the small preglomerular vessels, most likely via 5-ht1-like receptors. |
1993-04-01 |
2023-08-12 |
rat |
| M L Dufau, J C Tinajero, A Fabbr. Corticotropin-releasing factor: an antireproductive hormone of the testis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 2. 1993-03-29. PMID:8382638. |
the secretion of crf by the leydig cell is stimulated by lh, acting via release of serotonin (5ht) and autocrine activation of 5ht2 receptors. |
1993-03-29 |
2023-08-12 |
Not clear |
| M L Dufau, J C Tinajero, A Fabbr. Corticotropin-releasing factor: an antireproductive hormone of the testis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 2. 1993-03-29. PMID:8382638. |
serotonin acts on 5ht2 receptors in the leydig cell to stimulate crf secretion via a pertussis toxin insensitive g-protein and presumably through activation of phosphoinositide hydrolysis. |
1993-03-29 |
2023-08-12 |
Not clear |
| A Szczudli. [The role of serotonin in the pathophysiology of migraine]. Neurologia i neurochirurgia polska. vol Suppl 2. 1993-03-25. PMID:1337765. |
the evidence for this is: 5-ht concentrations in blood increase during the prodromal (aura) phase and subsequently, decrease to subnormal levels in the headache phase; migraine attacks may be triggered, in susceptible, subjects, by reserpine which depletes body serotonin; migraine attacks may be triggered, in susceptible subjects, by reserpine which depletes body serotonin; migraine attacks may be relieved by intravenous injection of 5-ht; medications known to affect 5-ht concentrations have been shown to be efficacious in both aborting (agonists of 5-ht1 receptors) and preventing (antagonists of 5-ht2 receptors) migraine attacks. |
1993-03-25 |
2023-08-11 |
human |
| G Maura, S Thellung, G C Andrioli, A Ruelle, M Raiter. Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8382263. |
the effect of 5-ht was insensitive to ketanserin (5-ht2) but antagonized by methiothepin (5-ht1/2) or by metergoline (5-ht1c/1d). |
1993-03-24 |
2023-08-12 |
human |
| E Edwards, C R Ashby, R Y Wan. Biochemical characterization of phosphoinositide hydrolysis stimulated by 5-HT3 receptor agonists. Neuroreport. vol 3. issue 12. 1993-03-11. PMID:1362896. |
serotonin (5-ht) stimulates phosphoinositide (pi) turnover in rat fronto-cingulate cortical slices and is probably mediated through the activation of both 5-ht2 and 5-ht3 receptors. |
1993-03-11 |
2023-08-11 |
rat |
| E Tanaka, N Baba, K Toshida, K Suzuk. Evidence for 5-HT2 receptor involvement in the stimulation of preovulatory LH and prolactin release and ovulation in normal cycling rats. Life sciences. vol 52. issue 7. 1993-03-11. PMID:8429759. |
the present study suggests that 5-ht stimulates preovulatory lh and prl surge and ovulation via 5-ht2 receptor under physiological conditions and that the effect of 5-ht depends on the critical period and the 24-hour periodicity. |
1993-03-11 |
2023-08-12 |
rat |
| T Shibano, T Tanaka, Y Morishima, M Yasuoka, K Watanabe, F Fuji. Pharmacological profile of a new 5-hydroxytryptamine2 receptor antagonist, DV-7028. Archives internationales de pharmacodynamie et de therapie. vol 319. 1993-03-08. PMID:1285670. |
dv-7028 bound to 5-ht2 receptors in rat brain membranes with a ki value of 22 nm and caused shifts to the right of the concentration-contraction curves to 5-ht in rat thoracic aorta and canine femoral arteries, which are attributed to activation of 5-ht2 receptors. |
1993-03-08 |
2023-08-11 |
human |
| A S Linden, D J Desmecht, H Amory, F A Rollin, C L Michaux, P Lekeu. Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. American journal of veterinary research. vol 54. issue 1. 1993-03-02. PMID:8427462. |
we determined whether the iv response to 5-ht in calves was attributable to stimulation of 5-ht2 receptors. |
1993-03-02 |
2023-08-12 |
cattle |
| A S Linden, D J Desmecht, H Amory, F A Rollin, C L Michaux, P Lekeu. Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. American journal of veterinary research. vol 54. issue 1. 1993-03-02. PMID:8427462. |
a specific 5-ht2 antagonist (metrenperone, 0.05 mg/kg of body weight) was administered im 30 minutes before the cattle were given a 5-minute iv 5-ht infusion. |
1993-03-02 |
2023-08-12 |
cattle |
| H Dabiré, K Chaouche-Teyara, C Cherqui, B Fournier, H Schmit. Pharmacological analysis of the cardiac effects of 5-HT and some 5-HT receptor agonists in the pithed rat. Fundamental & clinical pharmacology. vol 6. issue 6. 1993-02-24. PMID:1336759. |
it is concluded that in the pithed rat, the tachycardia induced by 5-ht remained unexplained (implication of 5-ht2 receptors probably different from the classical vascular 5-ht2 receptor, or implication of 5-ht1c receptors?). |
1993-02-24 |
2023-08-11 |
rat |
| A Nordber. Neuroreceptor changes in Alzheimer disease. Cerebrovascular and brain metabolism reviews. vol 4. issue 4. 1993-02-24. PMID:1486017. |
the number of serotonin (both 5-ht1 and 5-ht2) and glutamate receptors are also reduced. |
1993-02-24 |
2023-08-11 |
Not clear |
| E M Lutz, R Mitchell, M S Johnson, D MacEwa. Functional expression of 5-HT1c receptor cDNA in COS 7 cells and its influence on protein kinase C. FEBS letters. vol 316. issue 3. 1993-02-23. PMID:8422948. |
functional expression of 5-ht1c receptor cdna in cos 7 cells and its influence on protein kinase c. two subtypes of receptors for serotonin (5-hydroxytryptamine; 5-ht) are known to stimulate inositol (1,4,5)-trisphosphate production, the 5-ht1c and 5-ht2 receptors. |
1993-02-23 |
2023-08-12 |
dog |
| M Rinaldi-Carmona, C Congy, J Simiand, F Oury-Donat, P Soubrie, J C Breliere, G Le Fu. Repeated administration of SR 46349B, a selective 5-hydroxytryptamine2 antagonist, up-regulates 5-hydroxytryptamine2 receptors in mouse brain. Molecular pharmacology. vol 43. issue 1. 1993-02-23. PMID:8423772. |
adaptive changes in 5-hydroxytryptamine (5-ht)2 receptors were investigated in mice after repeated administration of sr 46349b, a potent, selective, and competitive 5-ht2 receptor antagonist (kl = 0.72 +/- 0.05 nm). |
1993-02-23 |
2023-08-12 |
mouse |
| A A Mustaf. Mechanisms of L-NG-nitro arginine methyl ester-induced antinociception in mice: a role for serotonergic and adrenergic neurons. General pharmacology. vol 23. issue 6. 1993-02-19. PMID:1362551. |
likewise, pretreatment with the serotonin 5-ht2 receptor blocker, ketanserin (1 mg/kg, i.p. |
1993-02-19 |
2023-08-11 |
mouse |
| J R Cazalets, Y Sqalli-Houssaini, F Clara. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. The Journal of physiology. vol 455. 1993-02-17. PMID:1362441. |
it decreased from around 10 s at 2 x 10(-5) m to 5 s at 10(-4) m. the effects of serotonin were blocked by a 5-ht1 antagonist (propranolol) and by 5-ht2 antagonists (ketanserin, cyproheptadine, mianserin). |
1993-02-17 |
2023-08-11 |
rat |