| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Schmidt, C K Black, V L Taylor, G M Fadayel, T M Humphreys, T R Nieduzak, S M Sorense. The 5-HT2 receptor antagonist, MDL 28,133A, disrupts the serotonergic-dopaminergic interaction mediating the neurochemical effects of 3,4-methylenedioxymethamphetamine. European journal of pharmacology. vol 220. issue 2-3. 1992-12-01. PMID:1425989. |
the selective 5-ht2 receptor antagonist mdl 28,133a dose dependently-blocked the long-term deficits in rat brain 5-ht concentrations produced by the substituted amphetamine analogue 3,4-methylenedioxymethamphetamine (mdma). |
1992-12-01 |
2023-08-11 |
rat |
| M S Choudhary, S Craigo, B L Rot. Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors. Molecular pharmacology. vol 42. issue 4. 1992-12-01. PMID:1435740. |
two serotonin receptors, the 5-ht2 and 5-ht1c, share a number of pharmacologic and structural properties while differing in their affinities for certain agonists and antagonists. |
1992-12-01 |
2023-08-11 |
Not clear |
| E Beubler, P Badhri, A Schirgi-Dege. 5-HT receptor antagonists and heat-stable Escherichia coli enterotoxin-induced effects in the rat. European journal of pharmacology. vol 219. issue 3. 1992-11-27. PMID:1330611. |
the enterotoxin may use 5-ht to stimulate prostaglandin formation via 5-ht2 receptors and to activate neuronal structures via 5-ht3 receptors. |
1992-11-27 |
2023-08-11 |
rat |
| U Scheffel, J R Lever, M Stathis, G A Ricaurt. Repeated administration of MDMA causes transient down-regulation of serotonin 5-HT2 receptors. Neuropharmacology. vol 31. issue 9. 1992-11-27. PMID:1359444. |
repeated administration of mdma causes transient down-regulation of serotonin 5-ht2 receptors. |
1992-11-27 |
2023-08-11 |
rat |
| U Scheffel, J R Lever, M Stathis, G A Ricaurt. Repeated administration of MDMA causes transient down-regulation of serotonin 5-HT2 receptors. Neuropharmacology. vol 31. issue 9. 1992-11-27. PMID:1359444. |
the present study examined short- and long-term effects of mdma (3,4-methylene-dioxymethamphetamine) on serotonin (5-ht2 and 5-ht1c) receptors in the brain of the rat. |
1992-11-27 |
2023-08-11 |
rat |
| P Nordström, M Asber. Suicide risk and serotonin. International clinical psychopharmacology. vol 6 Suppl 6. 1992-11-27. PMID:1385514. |
currently available research data suggest decreased brain stem levels of serotonin and 5-hiaa, altered distribution of presynaptic binding of the ligand 3h-imipramine to serotonin neurons and a region-specific increase in the number of postsynaptic 5ht2 receptors in the prefrontal cortex in suicide victims. |
1992-11-27 |
2023-08-11 |
Not clear |
| A Biegon, N Greune. Age-related changes in serotonin 5HT2 receptors on human blood platelets. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1410140. |
age-related changes in serotonin 5ht2 receptors on human blood platelets. |
1992-11-25 |
2023-08-11 |
human |
| A Biegon, N Greune. Age-related changes in serotonin 5HT2 receptors on human blood platelets. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1410140. |
serotonin receptors of the 5ht2 type were labeled on platelet membranes using tritiated ketanserin. |
1992-11-25 |
2023-08-11 |
human |
| P Mosca, F Y Lee, A J Kaumann, R J Groszman. Pharmacology of portal-systemic collaterals in portal hypertensive rats: role of endothelium. The American journal of physiology. vol 263. issue 4 Pt 1. 1992-11-25. PMID:1415713. |
the effects of 5-ht were competitively blocked by the 5-ht2 receptor-selective antagonist ici 169,369. |
1992-11-25 |
2023-08-11 |
rat |
| A S Undie, E Friedma. Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain. European journal of pharmacology. vol 226. issue 4. 1992-11-23. PMID:1327844. |
the effects of 5-ht were blocked by the nonselective 5-ht antagonist, methiotepin, the selective 5-ht2 antagonist, ketanserin, the mixed 5-ht2/5-ht1c antagonist, mianserin, and, with much less potency, by the selective 5-ht1c antagonist, mesulergine. |
1992-11-23 |
2023-08-11 |
rat |
| D Morin, R Monteau, G Hilair. Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study in the newborn rat. The Journal of physiology. vol 451. 1992-11-23. PMID:1403827. |
adding 5-ht and related agents to the bathing medium delayed and depressed the hypoglossal inspiratory discharge via activation of 5-ht2 receptors since these effects were elicited by 5-ht2 agonists (alpha-methyl-5-ht and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-hcl (doi)) but not by 5-ht1 agonists (ru 24969 and (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-oh-dpat)). |
1992-11-23 |
2023-08-11 |
rat |
| D Morin, R Monteau, G Hilair. Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study in the newborn rat. The Journal of physiology. vol 451. 1992-11-23. PMID:1403827. |
the 5-ht depression of the hypoglossal discharge was prevented by applying a pretreatment with a specific 5-ht2 antagonist (ketanserin). |
1992-11-23 |
2023-08-11 |
rat |
| C M Scott, K T Bunce, C F Spragg. Investigation of the 5-hydroxytryptamine receptor mediating the 'maintained' short-circuit current response in guinea-pig ileal mucosa. British journal of pharmacology. vol 106. issue 4. 1992-11-20. PMID:1393286. |
the scc responses to 5-ht were not inhibited by antagonists selective for 5-ht1 (methysergide, methiothepin), 5-ht2 (ketanserin) or 5-ht3 (ondansetron, ics205-930) receptors. |
1992-11-20 |
2023-08-11 |
Not clear |
| E M Hoenicke, S A Vanecek, J H Wood. The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403790. |
in substitution tests, compounds that shared antagonistic action at 5-hydroxytryptamine (5-ht)1c and 5-ht2 receptors produced discriminative stimulus effects similar to clozapine: cyproheptadine, metergoline, mianserin, pizotifen and fluperlapine. |
1992-11-20 |
2023-08-11 |
Not clear |
| E M Hoenicke, S A Vanecek, J H Wood. The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403790. |
5-ht antagonists selective for 5-ht2 vs. 5-ht1c receptors (e.g., ketanserin, pirenperone, risperidone and methiothepin) failed to produce substantial clozapine-appropriate responding. |
1992-11-20 |
2023-08-11 |
Not clear |
| B D Wilcox, L Rydelek-Fitzgerald, J J Jeffre. Regulation of collagenase gene expression by serotonin and progesterone in rat uterine smooth muscle cells. The Journal of biological chemistry. vol 267. issue 29. 1992-11-18. PMID:1400391. |
selective serotonin 5-ht2 receptor agonists were able to mimic the effect of the natural hormone, while the induction by serotonin could be blocked by 5-ht2 receptor antagonists. |
1992-11-18 |
2023-08-11 |
rat |
| P J Cowe. Serotonin receptor subtypes: implications for psychopharmacology. The British journal of psychiatry. Supplement. issue 12. 1992-11-18. PMID:1840764. |
three main families of 5-ht receptors (5-ht1, 5-ht2 and 5-ht3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. |
1992-11-18 |
2023-08-11 |
Not clear |
| E Edwards, C R Ashby, R Y Wan. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. vol 31. issue 7. 1992-11-06. PMID:1407401. |
when the effect of increasing the concentration of 5-ht on turnover of phosphoinositide was measured in the presence of a 1 microm concentration of the 5-ht3 receptor antagonist granisetron, the response obtained was similar to the response produced by the 5-ht2 receptor agonists, doi and alpha-me-5-ht. |
1992-11-06 |
2023-08-11 |
rat |
| S H Hensley, J L Cohe. Effects of serotonergic agonists and antagonists on ganglion cells in the goldfish retina. Visual neuroscience. vol 9. issue 3-4. 1992-11-02. PMID:1390393. |
the effects of exogenously applied serotonin on the ganglion cells could be blocked by the mixed 5-ht1/5-ht2 receptor antagonist methysergide but not by the 5-ht2 receptor antagonist mianserin or the dopamine receptor antagonist haloperidol. |
1992-11-02 |
2023-08-11 |
Not clear |
| L L Devaud, E B Hollingsworth, B R Coope. Alterations in extracellular and tissue levels of biogenic amines in rat brain induced by the serotonin2 receptor antagonist, ritanserin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1402896. |
taken together, these findings show that selective 5-ht2 receptor antagonism modulates da and 5-ht neurotransmission in a specific manner. |
1992-10-26 |
2023-08-11 |
rat |