| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Leonhardt, E Gorospe, B J Hoffman, M Teitle. Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Molecular pharmacology. vol 42. issue 2. 1992-09-30. PMID:1355262. |
the correspondence between the higher affinity of 5ht for the agonist low affinity state of the 5ht1c receptor, relative to the 5ht2 receptor, and the higher potency of 5ht in stimulating 5ht1c responses indicates that 5ht interacts with the agonist low affinity state of the 5ht1c and 5ht2 receptors in initiating its biological effects. |
1992-09-30 |
2023-08-11 |
human |
| S T Meller, S J Lewis, M J Brody, G F Gebhar. Vagal afferent-mediated inhibition of a nociceptive reflex by i.v. serotonin in the rat. II. Role of 5-HT receptor subtypes. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1511336. |
failed to alter the 5-ht dose-response curve, indicating that the effects of ketanserin were due to blockage of 5-ht2 receptors rather than alpha 1 receptors. |
1992-09-29 |
2023-08-11 |
rat |
| J Klisch, K M Bode-Greue. Ketanserin reduces neuronal calcium accumulation and cell death in the hippocampus of the Mongolian gerbil after transient forebrain ischemia. Brain research. vol 578. issue 1-2. 1992-09-25. PMID:1511266. |
since evidence is accumulating that serotonin (5-ht) exerts an excitatory effect on neurons via 5-ht2 receptors we tested the hypothesis that 5-ht2 receptor antagonists could protect neurons in the gerbil after transient bilateral carotid occlusion. |
1992-09-25 |
2023-08-11 |
Not clear |
| I W Beczkowska, J E Koch, R J Bodna. Naltrexone, serotonin receptor subtype antagonists, and glucoprivic intake: 1. 2-Deoxy-D-glucose. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513847. |
interactions between naloxone and either the general 5-ht antagonist methysergide or the 5-ht2 antagonist ritanserin or ketanserin produced smaller effects. |
1992-09-25 |
2023-08-11 |
Not clear |
| J E Koch, I W Beczkowska, R J Bodna. Naltrexone, serotonin receptor subtype antagonists, and glucoprivic intake: 2. Insulin. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513848. |
interactions between opiate antagonists and either 5-ht or 5-ht2 antagonists produced smaller effects. |
1992-09-25 |
2023-08-11 |
Not clear |
| J E Koch, I W Beczkowska, R J Bodna. Naltrexone, serotonin receptor subtype antagonists, and glucoprivic intake: 2. Insulin. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513848. |
pairing naltrexone with either ics-205,930 or ritanserin significantly suppressed insulin hyperphagia after 2 h. pairing naltrexone with each of the serotonin antagonists significantly enhanced insulin hyperphagia after 4 and 6 h. these data suggest that 5-ht2 and 5-ht3 receptor subtypes interact with opioid systems to modulate insulin hyperphagia. |
1992-09-25 |
2023-08-11 |
Not clear |
| S Champaneria, B Costall, R J Naylor, D W Robertso. Identification and distribution of 5-HT3 recognition sites in the rat gastrointestinal tract. British journal of pharmacology. vol 106. issue 3. 1992-09-24. PMID:1504752. |
binding of [3h]-gr65630 and [3h]-ly278584 to the terminal region of the small intestine was inhibited by 5-ht3 receptor ligands ondansetron and s-zacopride (and 5-hydroxytryptamine), but not by 5-ht1, 5-ht2, catecholamine, gamma-aminobutyric acid and opioid receptor ligands. |
1992-09-24 |
2023-08-11 |
rat |
| P Gupt. An endothelial 5-HT receptor that mediates relaxation in guinea-pig isolated jugular vein resembles the 5-HT1D subtype. British journal of pharmacology. vol 106. issue 3. 1992-09-24. PMID:1504754. |
an endothelial 5-ht receptor was studied in the presence of mesulergine (at 10.0 microm, a concentration sufficient to antagonize 5-ht2 receptor-mediated contractions and endothelium-independent relaxations to 5-ht). |
1992-09-24 |
2023-08-11 |
Not clear |
| N Merahi, H S Orer, R Laguzz. 5-HT2 receptors in the nucleus tractus solitarius: characterisation and role in cardiovascular regulation in the rat. Brain research. vol 575. issue 1. 1992-09-24. PMID:1504784. |
these cardiovascular effects were similar to those observed after the unilateral micro-injection of low doses (pmol) of 5-ht, and could be prevented by the prior micro-injections of the 5-ht2 antagonists ketanserin, ritanserin and piremperone. |
1992-09-24 |
2023-08-11 |
rat |
| N Merahi, H S Orer, R Laguzz. 5-HT2 receptors in the nucleus tractus solitarius: characterisation and role in cardiovascular regulation in the rat. Brain research. vol 575. issue 1. 1992-09-24. PMID:1504784. |
the potentiation of nmda depressor effects by 5-ht or dob could be totally prevented by ketanserin or piremperone, suggesting that 5-ht acting upon 5-ht2 receptors in the nts may intervene in the reflex control of blood pressure by modulating the glutamatergic transmission. |
1992-09-24 |
2023-08-11 |
rat |
| J N Murthy, M R Pranzatell. Brainstem 5-hydroxytrytamine1A binding sites are not down-regulated by agonists which induce tolerance in the rat: myoclonus and other serotonergic behaviors. Journal of receptor research. vol 12. issue 3. 1992-09-22. PMID:1387164. |
chronic injection with other drugs such as 1-propranolol, (+/-) pindolol and spiperone (5-ht1a and 5-ht2 antagonists), methysergide (5-ht1 and 5-ht2 antagonist), and agonists and antagonists at various other 5-ht receptors also had no effect on binding parameters. |
1992-09-22 |
2023-08-11 |
human |
| Y Wada, M Nakamura, H Hasegawa, N Yamaguch. Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. Neuroscience letters. vol 141. issue 1. 1992-09-22. PMID:1387198. |
this study assessed the effects of a serotonin (5-ht)1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), a 5-ht2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and a 5-ht2 antagonist ketanserin on fully kindled seizures from the hippocampus. |
1992-09-22 |
2023-08-11 |
Not clear |
| M Foguet, D Hoyer, L A Pardo, A Parekh, F W Kluxen, H O Kalkman, W Stühmer, H Lübber. Cloning and functional characterization of the rat stomach fundus serotonin receptor. The EMBO journal. vol 11. issue 9. 1992-09-22. PMID:1505525. |
after expression of this receptor in xenopus oocytes, the application of serotonin triggered the typical chloride current which presumably results from the activation of phospholipase c. the coupling to this response system was less efficient than that of the 5-ht1c or 5-ht2 receptors. |
1992-09-22 |
2023-08-11 |
mouse |
| H Jørgensen, U Knigge, J Warber. Involvement of 5-HT1, 5-HT2, and 5-HT3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. Neuroendocrinology. vol 55. issue 3. 1992-09-15. PMID:1386914. |
involvement of 5-ht1, 5-ht2, and 5-ht3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. |
1992-09-15 |
2023-08-11 |
rat |
| H Jørgensen, U Knigge, J Warber. Involvement of 5-HT1, 5-HT2, and 5-HT3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. Neuroendocrinology. vol 55. issue 3. 1992-09-15. PMID:1386914. |
we investigated in conscious male rats the effect of different 5-ht1, 5-ht2, and 5-ht3 receptor antagonists on the prl response to 5-ht or to the 5-ht precursor 5-hydroxytrytophan (5-htp) which was administered in combination with the 5-ht reuptake inhibitor fluoxetine. |
1992-09-15 |
2023-08-11 |
rat |
| M B Hanse. Involvement of non-classical 5-HT receptor in serotonin and cisapride induced secretion in hen colon. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 101. issue 2. 1992-09-14. PMID:1354103. |
neither brl 24924, 5-htp-dp, ketanserin, ics 205-930, prazosin, yohimbine, atropine nor piroxicam, covering the 5-ht1p, 5-ht2p, 5-ht2, 5-ht3, 5-ht4, adrenergic and muscarinic receptor types and the prostaglandin synthesis, altered 5-ht induced increases in short circuit current and cord conductance. |
1992-09-14 |
2023-08-11 |
Not clear |
| S L Heylen, Y G Gelder. Risperidone, a new antipsychotic with serotonin 5-HT2 and dopamine D2 antagonistic properties. Clinical neuropharmacology. vol 15 Suppl 1 Pt A. 1992-09-14. PMID:1379877. |
risperidone, a new antipsychotic with serotonin 5-ht2 and dopamine d2 antagonistic properties. |
1992-09-14 |
2023-08-11 |
Not clear |
| N A Darmani, B R Martin, R A Glenno. Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (+/- )-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1501117. |
the 5-hydroxytryptamine (5-ht)2 agonist (+/- )-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and antagonist ketanserin were evaluated for acute and chronic effects on the 5-ht2 receptor-mediated head-twitch response (htr) in mice. |
1992-09-11 |
2023-08-11 |
mouse |
| M Rinaldi-Carmona, C Congy, V Santucci, J Simiand, B Gautret, G Neliat, B Labeeuw, G Le Fur, P Soubrie, J C Brelier. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1501121. |
active serotonergic [5-hydroxytryptamine (5-ht2)] receptor antagonist, sr 46349b [trans, 4-([3z)3-(2-dimethylaminoethyl)oxyimino-3(2-flurophenyl++ +)propen-1-yl]phenol hemifumarate) has been characterized by a series of "in vitro" and "in vivo" methods. |
1992-09-11 |
2023-08-11 |
mouse |
| H T Kao, N Adham, M A Olsen, R L Weinshank, T A Branchek, P R Harti. Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology. FEBS letters. vol 307. issue 3. 1992-09-08. PMID:1644189. |
site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-ht2 receptor from a human to a rat pharmacology. |
1992-09-08 |
2023-08-11 |
human |