| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Joseph, C Tsering, S Grunfeld, K M Welc. Serotonin may have neurotoxic properties. Neuroscience letters. vol 136. issue 1. 1992-08-24. PMID:1635661. |
the results suggest that serotonin may be neurotoxic, and that this effect may be prevented by ketanserin, a specific 5ht2 antagonist. |
1992-08-24 |
2023-08-11 |
rat |
| M J Sumner, W Feniuk, J D McCormick, P P Humphre. Studies on the mechanism of 5-HT1 receptor-induced smooth muscle contraction in dog saphenous vein. British journal of pharmacology. vol 105. issue 3. 1992-08-20. PMID:1320980. |
in the presence of the 5-ht2 receptor antagonist, ritanserin (0.1 microm), concentration-effect curves (10 nm-300 microm) for 5-hydroxytryptamine (5-ht)-induced smooth muscle contraction were biphasic. |
1992-08-20 |
2023-08-11 |
dog |
| H Pertz, E Eic. O-acylated lysergol and dihydrolysergol-I derivatives as competitive antagonists of 5-HT at 5-HT2 receptors of rat tail artery. Allosteric modulation instead of pseudoirreversible inhibition. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 4. 1992-07-31. PMID:1320207. |
o-acylated lysergol and dihydrolysergol-i derivatives as competitive antagonists of 5-ht at 5-ht2 receptors of rat tail artery. |
1992-07-31 |
2023-08-11 |
rat |
| S Tanganelli, K Fuxe, L Ferraro, A M Janson, C Bianch. Inhibitory effects of the psychoactive drug modafinil on gamma-aminobutyric acid outflow from the cerebral cortex of the awake freely moving guinea-pig. Possible involvement of 5-hydroxytryptamine mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 4. 1992-07-31. PMID:1620245. |
the action on cortical gaba release may be dependent on activity at 5-ht2 receptors, since the action of modafinil in this respect is blocked by the non-selective 5-ht antagonist methysergide and the 5-ht2 antagonist ketanserin. |
1992-07-31 |
2023-08-11 |
mouse |
| M M Foreman, J L Hall, R L Lov. Effects of fenfluramine and para-chloroamphetamine on sexual behavior of male rats. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1615133. |
these studies indicate that acute release of serotonin evoked by these releasing agents has inhibitory effects on sexual sexual drive, capacity to achieve erection and threshold for ejaculation, and these effects are mediated by either the 5-ht1c or 5-ht2 receptor. |
1992-07-30 |
2023-08-11 |
rat |
| R Joseph, C Tsering, S Grunfeld, K M Welc. Further studies on platelet-mediated neurotoxicity. Brain research. vol 577. issue 2. 1992-07-23. PMID:1376633. |
this toxicity of 5ht appeared to be blocked by ketanserin, a 5ht2 receptor antagonist. |
1992-07-23 |
2023-08-11 |
human |
| J D Coffma. Alpha-adrenergic and serotonergic receptors and forearm venous compliance in normal human subjects. Journal of cardiovascular pharmacology. vol 19. issue 6. 1992-07-21. PMID:1376824. |
ketanserin, a 5-ht2 and alpha 1-adrenoceptor antagonist, attenuated the venous volume responses to 5-hydroxytryptamine and phenylephrine. |
1992-07-21 |
2023-08-11 |
human |
| D J Cushing, M L Cohe. Comparison of the serotonin receptors that mediate smooth muscle contraction in canine and porcine coronary artery. The Journal of pharmacology and experimental therapeutics. vol 261. issue 3. 1992-07-14. PMID:1602389. |
the rank order contractile potency for 5-ht, (alpha me-5-ht) and sumatriptan in porcine coronary artery was consistent with that established for a 5-ht2 receptor, whereas the rank order potency in canine coronary artery indicated non-5-ht2 receptor involvement. |
1992-07-14 |
2023-08-11 |
rat |
| J Yang, J Bao, D F S. [Effects of serotonin and norepinephrine on neuronal discharges of the nucleus tractus solitarii in medullary slices]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 13. issue 1. 1992-07-14. PMID:1605034. |
responding to both 5-ht and ne were 38 (88.4%) neurons, among which 21 were selected for studying the effect of ketanserin (a new 5-ht2 blocker). |
1992-07-14 |
2023-08-11 |
rat |
| Z Tomaszewski, M P Johnson, X Huang, D E Nichol. Benzofuran bioisosteres of hallucinogenic tryptamines. Journal of medicinal chemistry. vol 35. issue 11. 1992-07-08. PMID:1534585. |
the benzofuran analogues of the hallucinogens 5-methoxy-n,n-dimethyltryptamine and 5-methoxy-alpha-methyltryptamine were synthesized and evaluated for affinity at the serotonin 5-ht2 and 5-ht1a receptors in rat brain homogenate, labeled with [125i]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ([125i]doi) and [3h]-8-hydroxy-2-(n,n-di-n-propylamino)tetralin ([3h]-8-oh-dpat), respectively. |
1992-07-08 |
2023-08-11 |
rat |
| A Doble, D Girdlestone, O Piot, D Allam, J Betschart, A Boireau, A Dupuy, C Guérémy, J Ménager, J L Zunde. Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. British journal of pharmacology. vol 105. issue 1. 1992-07-07. PMID:1596688. |
pharmacological characterization of rp 62203, a novel 5-hydroxytryptamine 5-ht2 receptor antagonist. |
1992-07-07 |
2023-08-11 |
mouse |
| A J Kauman. 5-HT4-like receptors in mammalian atria. Journal of neural transmission. Supplementum. vol 34. 1992-07-07. PMID:1667872. |
these 5-ht receptors are blocked with moderate affinity (pkb = 6.7-6.9) by 3 alpha-trophanyl-1h-indole-3-carboxylate (ics 205930) but not by antagonists of alpha- and beta-adrenoceptors, or 5-ht1 subtypes, 5-ht2 and 5-ht3 receptors. |
1992-07-07 |
2023-08-11 |
mouse |
| E H Lee, W R Lin, H Y Chen, W H Shiu, K C Lian. Fluoxetine and 8-OH-DPAT in the lateral septum enhances and impairs retention of an inhibitory avoidance response in rats. Physiology & behavior. vol 51. issue 4. 1992-07-01. PMID:1534416. |
immediately after training, the septal serotonergic function was manipulated by pharmacological agents selectively blocking 5ht reuptake (fluoxetine and zimelidine), antagonizing 5ht2 receptors (ketanserin and ritanserin), or activating 5ht1a receptors, respectively. |
1992-07-01 |
2023-08-11 |
rat |
| E H Lee, W R Lin, H Y Chen, W H Shiu, K C Lian. Fluoxetine and 8-OH-DPAT in the lateral septum enhances and impairs retention of an inhibitory avoidance response in rats. Physiology & behavior. vol 51. issue 4. 1992-07-01. PMID:1534416. |
furthermore, postsynaptic 5ht receptor activation (not the 5ht2 receptor subtype) probably exerts a facilitatory effect while presynaptic 5ht1a receptor activation exerts an impairing effect on the memory consolidation process, probably due to autoreceptor inhibition of 5ht release. |
1992-07-01 |
2023-08-11 |
rat |
| R A Glennon, M Duka. Serotonin receptors and their ligands: a lack of selective agents. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816555. |
four major families of serotonin (5-hydroxytryptamine; 5-ht) receptors have been identified: 5-ht1, 5-ht2, 5-ht3 and 5-ht4. |
1992-06-30 |
2023-08-11 |
Not clear |
| M Nilsson, E Hansson, L Rönnbăc. Agonist-evoked Ca2+ transients in primary astroglial cultures--modulatory effects of valproic acid. Glia. vol 5. issue 3. 1992-06-23. PMID:1534067. |
the responses after 5ht and na stimulation were blocked to baseline levels after exposure to ketanserin (5ht2 receptor antagonist) and a combination of prazosin, yohimbine, and propranolol (alpha 1, alpha 2, and beta adrenoceptor antagonists, respectively). |
1992-06-23 |
2023-08-11 |
Not clear |
| N A Darmani, B R Martin, R A Glenno. Repeated administration of low doses of cocaine enhances the sensitivity of 5-HT2 receptor function. Pharmacology, biochemistry, and behavior. vol 41. issue 3. 1992-06-18. PMID:1584831. |
the acute and chronic effects of cocaine were evaluated on the 5-hydroxytryptamine (5-ht)-receptor 5-ht2 mediated behavioral function, the head-twitch response (htr), in mice. |
1992-06-18 |
2023-08-11 |
mouse |
| E Pyza, K Gołembiowska, L Antkiewicz-Michalu. Serotonin, dopamine, noradrenaline and their metabolites: levels in the brain of the house cricket (Acheta domesticus L.) during a 24-hour period and after administration of quipazine--a 5-HT2 receptor agonist. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 100. issue 3. 1992-06-18. PMID:1687530. |
serotonin, dopamine, noradrenaline and their metabolites: levels in the brain of the house cricket (acheta domesticus l.) during a 24-hour period and after administration of quipazine--a 5-ht2 receptor agonist. |
1992-06-18 |
2023-08-11 |
cricket |
| M Göther. 5-Hydroxytryptamine receptors. An example for the complexity of chemical transmission of information in the brain. Arzneimittel-Forschung. vol 42. issue 2A. 1992-06-16. PMID:1316754. |
1. the g protein receptor family, comprising, among the 5-ht receptors, the 5-ht1 and 5-ht2 subtypes and the 5-ht4 type, and 2. the ligand gated ion channels to which (at least according to the current knowledge) only one 5-ht receptor, the 5-ht3 type, belongs. |
1992-06-16 |
2023-08-11 |
Not clear |
| R M Woodward, M M Panicker, R Miled. Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 10. 1992-06-16. PMID:1350095. |
oocytes showing strong expression of 5-ht1c and 5-ht2 receptors became weakly responsive to the neurotransmitter dopamine, which, like 5-ht, elicited cl- currents through activation of the phosphatidylinositol/ca2+ messenger pathway. |
1992-06-16 |
2023-08-11 |
xenopus_laevis |