| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N A Darmani, R D Sewell, P J Nicholl. Acute effects of beclamide on brain regional monoamine concentrations, their metabolites and radioligand binding studies. The Journal of pharmacy and pharmacology. vol 43. issue 6. 1991-11-08. PMID:1717674. |
in radioligand binding studies beclamide lacked affinity and failed to displace radioligands from alpha 2, beta, 5-ht, 5-ht2 and dopamine d2 sites in selective loci of the rat brain. |
1991-11-08 |
2023-08-11 |
rat |
| Y Dohi, T F Lüsche. Altered intra- and extraluminal effects of 5-hydroxytryptamine in hypertensive mesenteric resistance arteries: contribution of the endothelium and smooth muscle. Journal of cardiovascular pharmacology. vol 18. issue 2. 1991-11-08. PMID:1717790. |
thus, contractile responses to 5-ht are mediated by homogeneous 5-ht2 receptors in rat mesenteric resistance arteries. |
1991-11-08 |
2023-08-11 |
rat |
| N K Hollenber. Implications of thrombosis and vasospasm in peripheral vascular disease. Journal of cardiovascular pharmacology. vol 17 Suppl 5. 1991-11-07. PMID:1717769. |
platelet activation releases not only thromboxane a2 but also serotonin, another vasoconstrictor agent that acts on blood vessels through a specific, 5-ht2 receptor. |
1991-11-07 |
2023-08-11 |
Not clear |
| J I Robertso. Serotonergic type-2 (5-HT2) antagonists: a novel class of cardiovascular drugs. Journal of cardiovascular pharmacology. vol 17 Suppl 5. 1991-11-07. PMID:1717773. |
serotonin, acting via the 5-ht2 receptor, can contribute to a range of cardiovascular problems, including portal hypertension, raynaud's phenomenon, carcinoid flushes, preeclampsia, hypertension, arterial atheroma, and restenosis after angioplasty or thrombolysis. |
1991-11-07 |
2023-08-11 |
Not clear |
| S Zeigler, J Lipton, A Toga, G Elliso. Continuous cocaine administration produces persisting changes in brain neurochemistry and behavior. Brain research. vol 552. issue 1. 1991-11-04. PMID:1655167. |
in vitro autoradiography was then utilized to examine persisting changes in receptor binding for d2 ([3h]spiperone), d1 ([3h]sch23390), benzodiazepine ([3h]flunitrazepam), 5-ht1 ([3h]5-ht), 5-ht2 ([3h]ketanserin), and muscarinic acetylcholine (ach) receptors ([3h]qnb; quinuclidinyl benzilate). |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
on the other hand, the non-selective 5-ht receptor antagonist, metergoline (2 and 4 mg/kg), the selective 5-ht2 receptor antagonist, ketanserin (1 and 2 mg/kg), the selective alpha 1-adrenoceptor blocker, prazosin (0.25 and 0.5 mg/kg) and the beta-blockers with no affinity for 5-ht receptors, betaxolol (4 and 8 mg/kg) and ici 118,551 (4 and 8 mg/kg), did not affect the anti-immobility effect of gepirone. |
1991-11-04 |
2023-08-11 |
rat |
| P K Eide, K Hol. Different role of 5-HT1A and 5-HT2 receptors in spinal cord in the control of nociceptive responsiveness. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1717872. |
the effects of the 5-hydroxytryptamine type-2 (5-ht2) receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and the 5-ht1a agonist (+)-8-hydroxy-2-(di-n-propylamino)-tetralin [(+)-8-oh-dpat] on nociceptive responsiveness were compared in mice. |
1991-11-04 |
2023-08-11 |
mouse |
| L Gentili, A Saija, G Luchetti, M Mass. Effect of the 5-HT2 antagonist ketanserin on salt appetite in the rat. Pharmacology, biochemistry, and behavior. vol 39. issue 1. 1991-11-01. PMID:1924500. |
ritanserin, too, a potent 5-ht2 antagonist showing a different receptor selectivity profile from that of ketanserin, suppressed doca-induced salt appetite, thus supporting the involvement of 5-ht receptors in the antinatriorexic action. |
1991-11-01 |
2023-08-11 |
rat |
| T S Rao, P C Contreras, J A Cler, M R Emmett, S J Mick, S Iyengar, P L Woo. Clozapine attenuates N-methyl-D-aspartate receptor complex-mediated responses in vivo: tentative evidence for a functional modulation by a noradrenergic mechanism. Neuropharmacology. vol 30. issue 6. 1991-10-31. PMID:1681442. |
antagonists of dopamine (d2), serotonin (5-ht)-5-ht1, 5-ht2 and 5-ht3 [haloperidol, propranolol, ritanserin, ics 205-930 [(3-tropanyl-indole-3-carboxylate methiodide)] respectively], did not reverse the response to harmaline. |
1991-10-31 |
2023-08-11 |
Not clear |
| R Samanin, J C Neill, G Grignaschi, I M Padura, A Bizzi, S Garattin. Role of 5-HT receptors in the effect of d-fenfluramine on gastric emptying and feeding behaviour as examined in the runway test. European journal of pharmacology. vol 197. issue 1. 1991-10-24. PMID:1909959. |
with metergoline, a non-selective serotonin (5-ht) receptor antagonist, ritanserin, a selective 5-ht2 and 5-ht1c receptor antagonist, and xylamidine, a 5-ht antagonist which has poor access to the brain. |
1991-10-24 |
2023-08-11 |
rat |
| P J Simpson, J A Schelm, J A Jakubowski, J K Smallwoo. The role of serotonin (5HT2) receptor blockade in myocardial reperfusion injury: effects of LY53857 in a canine model of myocardial infarction. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1653847. |
the role of serotonin (5ht2) receptor blockade in myocardial reperfusion injury: effects of ly53857 in a canine model of myocardial infarction. |
1991-10-17 |
2023-08-11 |
human |
| P J Simpson, J A Schelm, J A Jakubowski, J K Smallwoo. The role of serotonin (5HT2) receptor blockade in myocardial reperfusion injury: effects of LY53857 in a canine model of myocardial infarction. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1653847. |
either vehicle (0.9% nacl) or the serotonin (5ht2) receptor antagonist ly53857 was infused i.v. |
1991-10-17 |
2023-08-11 |
human |
| P J Simpson, J A Schelm, J A Jakubowski, J K Smallwoo. The role of serotonin (5HT2) receptor blockade in myocardial reperfusion injury: effects of LY53857 in a canine model of myocardial infarction. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1653847. |
verification of functional 5ht2 receptor antagonism in the circulating blood of the ly53857-treated dogs was monitored throughout the experiments by periodic assessment of ex vivo platelet reactivity to exogenous serotonin. |
1991-10-17 |
2023-08-11 |
human |
| K D Burris, M Breeding, E Sanders-Bus. (+)Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1679849. |
activation of central serotonin 5ht2 receptors is believed to be the primary mechanism whereby lysergic acid diethylamide (lsd) and other hallucinogens induce psychoactive effects. |
1991-10-17 |
2023-08-11 |
rat |
| T Yamamoto, E A Walker, J H Wood. Agonist and antagonist properties of serotonergic compounds in pigeons trained to discriminate either quipazine or L-5-hydroxytryptophan. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1890629. |
in addition, a correlation coefficient of 0.78 was calculated between the potencies of 5-ht compounds to attenuate the quipazine stimulus and the binding affinities of these compounds for the 5-ht2 receptor in rat brain. |
1991-10-17 |
2023-08-11 |
rat |
| K C Fone, A J Robinson, C A Marsde. Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats. British journal of pharmacology. vol 103. issue 2. 1991-10-07. PMID:1832068. |
ligand binding studies and dose-response studies with a range of selective 5-ht antagonists are required to establish whether bmc and wds are mediated by different subtypes of 5-ht2 receptors. |
1991-10-07 |
2023-08-11 |
rat |
| A C Barton, H C Kang, M S Rinaudo, F J Monsma, R M Stewart-Fram, J A Macinko, R P Haugland, M A Ariano, D R Sible. Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity. Brain research. vol 547. issue 2. 1991-10-04. PMID:1679366. |
the interaction of these fluorescent ligands with dopamine and serotonin receptors was evaluated by examining their ability to compete for radioligand binding to d1 and d2 dopamine receptors and 5-ht1a, 5-ht1c and 5-ht2 serotonin receptors. |
1991-10-04 |
2023-08-11 |
Not clear |
| M A Ariano, H C Kang, R P Haugland, D R Sible. Multiple fluorescent ligands for dopamine receptors. II. Visualization in neural tissues. Brain research. vol 547. issue 2. 1991-10-04. PMID:1884196. |
the pharmacological specificity for each of the different d1 fluorescent antagonist ligands in the tissues was determined by competition with 100-fold excess of unlabeled sch 23390 (non-specific binding), spiroperidol (binding selectivity), the stereoactive paired isomers of butaclamol, and the serotonin 5-ht2 receptor antagonist ketanserin. |
1991-10-04 |
2023-08-11 |
rat |
| J Gerlac. New antipsychotics: classification, efficacy, and adverse effects. Schizophrenia bulletin. vol 17. issue 2. 1991-10-03. PMID:1715608. |
(3) nondopamine drugs such as serotonin (5ht1) agonists, 5ht2 antagonists, 5ht3 antagonists, and gamma-amino-butyric-acid-a (gaba-a) benzodiazepine agonists have anxiolytic, antidepressant, antiaggressive, and maybe antiparkinsonian effects and may play an adjunctive role in the treatment of schizophrenia. |
1991-10-03 |
2023-08-11 |
Not clear |
| G S Baxter, D A Craig, D E Clark. 5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 5. 1991-10-03. PMID:1881455. |
the concentration-effect curve to 5-ht was unaffected by potent antagonists for 5-ht1, 5-ht2, 5-ht3 and so called 5-ht1p receptors (metergoline, methysergide, ketanserin, ondansetron, n-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide), but was antagonized competitively by ics 205-930 (pa2 = 6.7). |
1991-10-03 |
2023-08-11 |
rat |