| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Tortarolo, P Veglianese, N Calvaresi, A Botturi, C Rossi, A Giorgini, A Migheli, C Bendott. Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Molecular and cellular neurosciences. vol 23. issue 2. 2003-09-30. PMID:12812752. |
as the disease progressed, activated p38mapk also accumulated in hypertrophic astrocytes and reactive microglia, as demonstrated by colocalization with gfap and cd11b immunostaining, respectively. |
2003-09-30 |
2023-08-12 |
mouse |
| K E Rhodes, L D F Moon, J W Fawcet. Inhibiting cell proliferation during formation of the glial scar: effects on axon regeneration in the CNS. Neuroscience. vol 120. issue 1. 2003-09-30. PMID:12849739. |
almost complete elimination of ng2 oligodendrocyte progenitor cells from the lesion site was seen up to 7 dpl in arac-infused animals; reduced numbers of reactive cd11b microglia were also seen but no effects were seen on the injury response of gfap astrocytes. |
2003-09-30 |
2023-08-12 |
rat |
| Alicia A Babcock, William A Kuziel, Serge Rivest, Trevor Owen. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944523. |
in situ hybridization combined with immunohistochemistry for ionized binding calcium adapter molecule (iba)1 or glial fibrillary acidic protein (gfap) identified iba1+ microglia and gfap+ astrocytes as major sources of mcp-1/ccl2 within the lesion-reactive hippocampus. |
2003-09-16 |
2023-08-12 |
mouse |
| David A Bechtold, Ian R Brow. Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial cells of the rat hippocampus following hyperthermia. Neurochemical research. vol 28. issue 8. 2003-09-03. PMID:12834255. |
a pronounced induction of these low-molecular-weight stress proteins was apparent in populations of glial cells such as astrocytes and microglia that were identified using cell-specific markers (gfap for astrocytes and the lectin gsa i-b4 for microglia). |
2003-09-03 |
2023-08-12 |
rat |
| Stanislava Dalton, Volodymyr Gerzanich, Mingkui Chen, Yafeng Dong, Yaroslav Shuba, J Marc Simar. Chlorotoxin-sensitive Ca2+-activated Cl- channel in type R2 reactive astrocytes from adult rat brain. Glia. vol 42. issue 4. 2003-08-04. PMID:12730953. |
chlorotoxin-tagged cells isolated by flow cytometry and cultured up to two passages exhibit positive labeling for gfap and vimentin, but not for prolyl 4-hydroxylase (fibroblast), a2b5 (o2a progenitor), or ox-42 (microglia). |
2003-08-04 |
2023-08-12 |
rat |
| S T Chen, J R Hsu, P C Hsu, J I Chuan. The retina as a novel in vivo model for studying the role of molecules of the Bcl-2 family in relation to MPTP neurotoxicity. Neurochemical research. vol 28. issue 6. 2003-07-08. PMID:12718432. |
in animals that received mptp injection, an increase in immunostaining of gfap, glutamine synthetase, and mac-1 (cd11b) in astrocytes, müller cells, and microglia was invariably observed, indicating an activation or dysfunction of retinal glial cells. |
2003-07-08 |
2023-08-12 |
mouse |
| Shan-Xue Jin, Zhi-Ye Zhuang, Clifford J Woolf, Ru-Rong J. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764087. |
the activated p38 in the spinal cord is restricted entirely to microglia; phospho-p38 colocalizes only with the microglial marker ox-42 and not with either the neuronal marker neuronal-specific nuclear protein or the astrocyte marker gfap. |
2003-06-25 |
2023-08-12 |
rat |
| Anton B Tonchev, Tetsumori Yamashima, Liang Zhao, Hideyuki Okan. Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys. Glia. vol 42. issue 3. 2003-06-10. PMID:12673828. |
the ischemic insult significantly increased the number of proliferating cells in the hippocampus and temporal neocortex, where the majority brdu-labeled cells expressed markers for microglia (iba1, cd68, and ham56) or astrocytes (s-100beta and glial fibrillary acidic protein [gfap]). |
2003-06-10 |
2023-08-12 |
monkey |
| G Trillo-Pazos, A Diamanturos, L Rislove, T Menza, W Chao, P Belem, S Sadiq, S Morgello, L Sharer, D J Volsk. Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain pathology (Zurich, Switzerland). vol 13. issue 2. 2003-06-04. PMID:12744468. |
sections from frontal cortex and basal ganglia were stained by immunohistochemistry for cd68 (microglia), gfap (astrocytes), map2 (neurons), and p24 (hiv-1 positive cells) and different cell types were microdissected by lcm. |
2003-06-04 |
2023-08-12 |
Not clear |
| Manfred Oehmichen, Till Walter, Christoph Meissner, Hans-Jürgen Friedric. Time course of cortical hemorrhages after closed traumatic brain injury: statistical analysis of posttraumatic histomorphological alterations. Journal of neurotrauma. vol 20. issue 1. 2003-04-18. PMID:12614591. |
following routine staining and immunohistochemical staining of microglia (cd68), astrocytes (gfap) and injured axons (beta-app), paraffin sections were examined by light microscopy for the presence of the selected histomorphological features. |
2003-04-18 |
2023-08-12 |
Not clear |
| Neslihan Cetin, Kelly Ball, Murat Gokden, Nancy F Cruz, Gerald A Diene. Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells. Neurochemistry international. vol 42. issue 5. 2003-04-09. PMID:12510019. |
local rates of net [2-14c]acetate uptake and glucose utilization (cmr(glc)), determined with [14c]deoxyglucose to assay overall metabolic activity of all brain cells, were assayed 7 days after a cannula placement; adjacent brain sections were immunostained to identify glial fibrillary acidic protein-positive (gfap(+)) astrocytes and microglia plus macrophages (lectin-positive cells). |
2003-04-09 |
2023-08-12 |
rat |
| Dong Hoon Shin, Eunju Lee, Sa Sun Ch. Glial cells in the chicken optic tectum. Brain research. vol 962. issue 1-2. 2003-04-01. PMID:12543473. |
we mapped the distribution of the three neuroglial cells, oligodendrocytes, astrocytes and microglia, in the chicken optic tectum using their specific markers, transferrin binding protein (tfbp), glial fibrillary acidic protein (gfap), and ricinus communis agglutinin-1 (rca-1), respectively. |
2003-04-01 |
2023-08-12 |
chicken |
| Mikhail Yu Stepanichev, Irina M Zdobnova, Alexander A Yakovlev, Mikhail V Onufriev, Natalia A Lazareva, Irina I Zarubenko, Natalia V Gulyaev. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). Journal of neuroscience research. vol 71. issue 1. 2003-03-12. PMID:12478619. |
seven days after the surgery brain sections were stained with cresyl violet (nissl), for fragmented dna (tunel), glial fibrillar acidic protein (gfap) and isolectin b4-reactive microglia. |
2003-03-12 |
2023-08-12 |
human |
| Peter R Mouton, Jeffrey M Long, De-Liang Lei, Victor Howard, Mathias Jucker, Michael E Calhoun, Donald K Ingra. Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426043. |
astrocytes and microglia were visualized using immunocytochemistry for glial fibrillary acidic protein (gfap) and complement receptor 3 (mac-1), respectively, and numbers of each cell type in dentate gyrus (dg) and ca1 regions were estimated using the optical fractionator method. |
2003-01-29 |
2023-08-12 |
mouse |
| Izabela Figiel, Anna Fiedorowic. Trimethyltin-evoked neuronal apoptosis and glia response in mixed cultures of rat hippocampal dentate gyrus: a new model for the study of the cell type-specific influence of neurotoxins. Neurotoxicology. vol 23. issue 1. 2003-01-13. PMID:12164551. |
in parallel to studies the effects of tmt on neurons, its concentration dependent actions on astroglia and microglia were also examined using gfap and gs-b4 isolectin as immunocytochemical markers, respectively. |
2003-01-13 |
2023-08-12 |
rat |
| Steven L O'Donnell, Terra J Frederick, J Kyle Krady, Susan J Vannucci, Teresa L Woo. IGF-I and microglia/macrophage proliferation in the ischemic mouse brain. Glia. vol 39. issue 1. 2002-08-23. PMID:12112378. |
in contrast, staining within damaged regions showed high numbers of cells immunopositive for f4/80 and lectin b(4) indicative of microglia and macrophages but no cells immunopositive for the astrocytic proteins gfap or s-100beta. |
2002-08-23 |
2023-08-12 |
mouse |
| L D Moon, J W Fawcet. Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2. The European journal of neuroscience. vol 14. issue 10. 2002-04-23. PMID:11860461. |
treatment with antibodies against tgfbeta1 and tgfbeta2 attenuated (but did not abolish) the response of glial fibrillary acidic protein (gfap)-immunoreactive astrocytes and of ng2-immunoreactive glia but did not attenuate the response of cr3-immunoreactive microglia and macrophages. |
2002-04-23 |
2023-08-12 |
rat |
| Diane R Goddard, Martin Berry, Sara L Kirvell, Arthur M But. Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo. Journal of anatomy. vol 200. issue Pt 1. 2002-04-19. PMID:11833655. |
glial cells were unaffected by treatment with saline or low fgf-2, whereas high fgf-2 induced reactive changes in glial cell types: (1) there was increased gfap expression in astrocytes, demonstrated by western blot and immunohistochemistry, and astrocytes appeared hypertrophic, with increased process thickness and number; (2) the number of ed1 labelled microglia/macrophages was doubled, from 47 +/- 6 to 114 +/- 17 cells per field (0.75 mm2; values are mean +/- sem), and microglia appeared activated, with a multipolar and granular appearance; (3) ng2 positive glial cells appeared more fibrous and there was increased density of processes, although there was no significant increase in their number; (4) oligodendrocyte somata were enlarged and there was a loss of myelin sheaths. |
2002-04-19 |
2023-08-12 |
rat |
| R W Rodrigues, V C Gomide, G Chad. Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine. The International journal of neuroscience. vol 109. issue 1-2. 2002-02-21. PMID:11699344. |
following, animals were sacrificed and the tyrosine hydroxylase (th) positive dopamine cells, the glial fibrillary acidic protein (gfap) immunolabeled astrocytes and the ox42 immunoreactive microglia were visualized by mean of immunohistochemistry and quantified by stereologic method employing the optical disector and the point intercepts. |
2002-02-21 |
2023-08-12 |
rat |
| A Martínez-Contreras, M Huerta, S Lopez-Perez, J García-Estrada, S Luquín, C Beas Zárat. Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. Journal of neuroscience research. vol 67. issue 2. 2002-02-21. PMID:11782964. |
double labeling to glial fibrillary acidic protein (gfap) and brdu, or isolectin-b(4) and brdu identified astrocytes or microglia cells that proliferated; immunoblotting and immunoreactivity to vimentin served for assess immaturity of astrocytic intermediate filaments. |
2002-02-21 |
2023-08-12 |
rat |