| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Cai, Junyong Ruan, Xi Shao, Yuanjun Ding, Kangning Xie, Chi Tang, Zedong Yan, Erping Luo, Da Jin. Oxygen Enrichment Mitigates High-Altitude Hypoxia-Induced Hippocampal Neurodegeneration and Memory Dysfunction Associated with Attenuated Tau Phosphorylation. High altitude medicine & biology vol 22 issue 3 2021 34348049 |
oxygen enrichment mitigates high-altitude hypoxia-induced hippocampal neurodegeneration and memory dysfunction associated with attenuated tau phosphorylation. |
2021-10-11 |
2023-01-26 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caill\\xc3\\xa9, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry vol 11 issue 1 2021 34588422 |
distinct amyloid and tau pet signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. |
2021-10-11 |
2023-01-26 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caill\\xc3\\xa9, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry vol 11 issue 1 2021 34588422 |
we aimed to investigate the amyloid and tau pet imaging signatures of patients with amnestic syndrome of the hippocampal type (asht) and study their clinical and imaging progression according to their initial pet imaging status. |
2021-10-11 |
2023-01-26 |
Not clear |
| Tarek M Mohamed, Menna Allah M Youssef, Azza A Bakry, Mai M El-Kei. Alzheimer's disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid. Metabolic brain disease vol 36 issue 2 2021 33159653 |
as a result, an increase in hippocampus glucose, tau protein expression, mda and glut2 in the ad group (g3) compared to control groups (g1 and g2) has been recorded. |
2021-10-05 |
2023-01-26 |
rat |
| Michelle Lima Garcez, Ricardo Chiengo Sapalo Cassoma, Francielle Mina, Tatiani Bellettini-Santos, Aline Pereira da Luz, Gustavo Luis Schiavo, Eduarda Behenck Medeiros, Ana Carolina Brunatto Falchetti Campos, Sabrina da Silva, Lisienny Campoli Tono Rempel, Amanda Valnier Steckert, Tatiana Barichello, Josiane Budn. Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose. Metabolic brain disease vol 36 issue 2 2021 33219893 |
d-gal induced synaptophysin and bcl-2 decrease in the hippocampus and phosphorylated tau increase in the prefrontal cortex. |
2021-10-05 |
2023-01-26 |
rat |
| Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan L. NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia. Ecotoxicology and environmental safety vol 225 issue 2021 34492628 |
moreover, both total unphosphorylated tau and phosphorylated tau (ptau; t231 and s262) expressions in the hippocampus and cortex were upregulated, unveiling tau phosphorylation. |
2021-10-05 |
2023-01-26 |
mouse |
| Jiaojiao Huang, Xuemin Peng, Rongping Fan, Kun Dong, Xiaoli Shi, Shujun Zhang, Xuefeng Yu, Yan Yan. Disruption of Circadian Clocks Promotes Progression of Alzheimer's Disease in Diabetic Mice. Molecular neurobiology vol 58 issue 9 2021 34018152 |
we also found that the hyperphosphorylated tau protein exhibited more disruptive daily oscillations in db/db mice hippocampus under the 6:18 light/dark cycle. |
2021-10-04 |
2023-01-26 |
mouse |
| Sharay E Setti, Miranda N Ree. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic brain disease vol issue 2021 34591222 |
this review focuses on evidence in the literature that describes how one potential age-related change, that of glutamate-mediated increases in neuronal activity, may ultimately increase the risk of developing ad and promote the spread of tau pathology in ad-affected brains from the ec to later regions such as the hippocampus and prefrontal cortex. |
2021-09-30 |
2023-01-26 |
Not clear |
| Alberto Fern\\xc3\\xa1ndez, Luc\\xc3\\xada Vaquero, Ricardo Bajo, Pilar Zuluag. Apolipoprotein E \\xc9\\x9b4-related effects on cognition are limited to the Alzheimer's disease spectrum. GeroScience vol issue 2021 34591236 |
our analyses included apoe4 genotype, neuropsychological variables, amyloid-\xce\xb2eta (a\xce\xb2) and tau markers, fdg-pet values, and hippocampal volumetry data derived from the healthy controls sample of the adni database. |
2021-09-30 |
2023-01-26 |
human |
| Nils Richter, G\\xc3\\xa9rard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 78 issue 4 2021 33164934 |
entorhinal tau predicts hippocampal activation and memory deficits in alzheimer's disease. |
2021-09-29 |
2023-01-26 |
Not clear |
| Nils Richter, G\\xc3\\xa9rard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 78 issue 4 2021 33164934 |
recent findings indicate that tau accumulation may drive hippocampal hyperactivity in cognitively normal aging, but it remains to be elucidated how tau accumulation is related to neural activation in ad. |
2021-09-29 |
2023-01-26 |
Not clear |
| Giuseppina Amadoro, Valentina Latina, Bijorn Omar Balzamino, Rosanna Squitti, Monica Varano, Pietro Calissano, Alessandra Micer. Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration. Frontiers in neuroscience vol 15 issue 2021 34566573 |
according to the cholinergic hypothesis, an early and progressive synaptic and neuronal loss in a vulnerable population of basal forebrain involved in memory and learning processes leads to degeneration of cortical and hippocampal projections followed by cognitive impairment with accumulation of misfolded/aggregated a\xce\xb2 and tau protein. |
2021-09-29 |
2023-01-26 |
Not clear |
| Anastasie Mat\\xc3\\xa9 de G\\xc3\\xa9rando, Marie d'Orange, Emma Augustin, Charl\\xc3\\xa8ne Jos\\xc3\\xa9phine, Gw\\xc3\\xa9naelle Aur\\xc3\\xa9gan, Myl\\xc3\\xa8ne Gaudin-Gu\\xc3\\xa9rif, Martine Guillermier, Anne-Sophie H\\xc3\\xa9rard, Lev Stimmer, Fanny Petit, Pauline Gipchtein, Caroline Jan, Carole Escartin, Erwan Selingue, K\\xc3\\xa9vin Carvalho, David Blum, Emmanuel Brouillet, Philippe Hantraye, Marie-Claude Gaillard, Gilles Bonvento, Alexis-Pierre Bemelmans, Karine Cambo. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state. Brain : a journal of neurology vol 144 issue 4 2021 33842937 |
using stereological counting of astrocytes, we report that, as for neurons, soluble tau species are highly toxic to some subpopulations of astrocytes in the hippocampus, whereas the accumulation of tau aggregates does not affect their survival. |
2021-09-24 |
2023-01-26 |
mouse |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology vol 4 issue 1 2021 34480097 |
it is thought that chronic hyperglycemia leads to neuroinflammation and tau hyperphosphorylation in the hippocampus leading to cognitive decline, but effects on hippocampal network activity are unknown. |
2021-09-24 |
2023-01-26 |
human |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology vol 4 issue 1 2021 34480097 |
consistent with previous investigations, we found increases in phosphorylated tau in stz animals' hippocampus and cortex, which might account for the observed oscillatory and cognitive changes. |
2021-09-24 |
2023-01-26 |
human |
| Mar\\xc3\\xada Florencia Zappa Villar, Juliette L\\xc3\\xb3pez Hanotte, Rosana Crespo, Joaqu\\xc3\\xadn Pardo, Paula Cecilia Reggian. Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement. Hippocampus vol 31 issue 10 2021 34324234 |
this approach enhanced igf1 signaling in the hippocampus and dampened sad phosphorylated tau. |
2021-09-21 |
2023-01-26 |
rat |
| Mar\\xc3\\xada Florencia Zappa Villar, Juliette L\\xc3\\xb3pez Hanotte, Rosana Crespo, Joaqu\\xc3\\xadn Pardo, Paula Cecilia Reggian. Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement. Hippocampus vol 31 issue 10 2021 34324234 |
we conclude that exogenous activation of igf1 signaling pathway, 1 week after intracerebroventricular stz administration, protects hippocampal immature neurons, dampens phosphorylated tau levels, improves synaptic function and therefore performs therapeutically on the sad stz model. |
2021-09-21 |
2023-01-26 |
rat |
| Christopher J Harris, Nora E Gray, Maya Caruso, Marguex Hunter, Martina Ralle, Joseph F Quin. Copper Modulation and Memory Impairment due to Hippocampal Tau Pathology Journal of Alzheimer's disease : JAD vol 78 issue 1 2021 32250309 |
copper modulation and memory impairment due to hippocampal tau pathology background:environmental copper has been implicated in the pathogenesis of alzheimer\xe2\x80\x99s disease based on evidence that: 1) brain copper levels increase with age, 2) copper promotes misfolding and toxicity of amyloid-\xce\xb2 in vitro, 3) copper-modulating interventions reduce amyloid pathology in animal models. |
2021-09-20 |
2023-01-26 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1\\xce\\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport vol 32 issue 10 2021 34029285 |
il-6 and il-1\xce\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. |
2021-09-20 |
2023-01-26 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1\\xce\\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport vol 32 issue 10 2021 34029285 |
as inflammatory cytokines have been shown to regulate tau phosphorylation, in the present study, the aim was to determine whether cognitive impairment caused by chronic alcohol exposure is associated with neuroinflammation and tau hyperphosphorylation in the hippocampus. |
2021-09-20 |
2023-01-26 |
mouse |