| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology vol 40 issue 5 2021 32698244 |
the concept of the hierarchal spread of neurofibrillary tangles (nfts) from the hippocampus to the cortex in alzheimer's disease (ad)/aging brains, initially proposed by braak and braak, revolutionized our understanding by putatively explaining that tau lesions are being unidirectionally extended along neural connections. |
2021-08-18 |
2023-01-26 |
human |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology vol 40 issue 5 2021 32698244 |
surprisingly, this profile shift from 4r to 3r tau is shared with the hierarchal spread of nft around the hippocampus, which is hardly explained by a simple mechanism such as propagation of a single tau molecule. |
2021-08-18 |
2023-01-26 |
human |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines vol 5 issue 1 2021 32219000 |
in vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis, and neuronal loss in the hippocampus of immunized mice. |
2021-08-16 |
2023-01-26 |
mouse |
| Yosra Nadhimi, Daniel A Llan. Does hearing loss lead to dementia? A review of the literature. Hearing research vol 402 issue 2021 32814645 |
the data suggest that noise-exposure produces a toxic milieu in the hippocampus consisting of a spike in glucocorticoid levels, elevations of mediators of oxidative stress and excitotoxicity, which as a consequence induce cessation of neurogenesis, synaptic loss and tau hyperphosphorylation. |
2021-08-13 |
2023-01-26 |
human |
| Christina N Rogers Flattery, Rebecca F Rosen, Aaron S Farberg, Jeromy M Dooyema, Patrick R Hof, Chet C Sherwood, Lary C Walker, Todd M Preus. Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans. Brain structure & function vol 225 issue 8 2021 32909100 |
we also sought evidence of\xc2\xa0a\xce\xb2\xc2\xa0deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. |
2021-08-11 |
2023-01-26 |
human |
| Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine vol 52 issue 8 2021 32859953 |
the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. |
2021-08-10 |
2023-01-26 |
Not clear |
| Elisa Garc\\xc3\\xada-Lara, Samuel Aguirre, N\\xc3\\xbaria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Su\\xc3\\xb1ol, Rub\\xc3\\xa9n Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeli. Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia. Biomedicines vol 9 issue 7 2021 34356892 |
here, we showed that a single hippocampal administration of mcrp in mice induced memory loss, lasting at least 6 months, along with neurodegenerative changes detected by increased levels of hyperphosphorylated tau protein and a decrease of the neuroplasticity marker |
2021-08-09 |
2023-01-26 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and \\xce\\xb1-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications vol 2 issue 2 2021 33094280 |
unilateral hippocampal injection of tau fibrils or \xce\xb1-synuclein fibrils, and to a lesser extent tau\xe2\x80\x89+\xe2\x80\x89\xce\xb1-synuclein copolymer fibrils prepared from co-incubating individual recombinant monomers, induced robust phosphorylated tau pathology in ps19 mice relative to control mice. |
2021-08-07 |
2023-01-26 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and \\xce\\xb1-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications vol 2 issue 2 2021 33094280 |
in m20 mice, unilateral hippocampal injection of \xce\xb1-synuclein fibrils or tau fibrils induced robust bilateral phosphorylated \xce\xb1-synuclein pathology, while tau\xe2\x80\x89+\xe2\x80\x89\xce\xb1-synuclein copolymer injection resulted in restricted phosphorylated \xce\xb1-synuclein pathology predominantly in the ipsilateral cortex. |
2021-08-07 |
2023-01-26 |
mouse |
| Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, R\\xc3\\xa9gis Mateus H\\xc3\\xb6zer, Felippo Bifi, Cristiane Matt\\xc3\\xa9, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry vol 87 issue 2021 33065257 |
genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of tau. |
2021-08-04 |
2023-01-26 |
rat |
| Jos\\xc3\\xa9 Gulfo, Joana P\\xc3\\xa9rez de San Rom\\xc3\\xa1n, Angelo Ledda, Felix Junyent, Mar\\xc3\\xada J Ram\\xc3\\xadrez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3\\xce\\xb2 and phosphorylated-Tau levels in the hippocampus. PloS one vol 16 issue 2 2021 33592009 |
we used cbg-/- mice, which display low total-corticosterone and high free-corticosterone blood levels at the nadir of corticosterone secretion (morning) and at rest to evaluate the hippocampus for total- and free-corticosterone levels; 11\xce\xb2-hydroxysteroid dehydrogenase expression and activity; the expression of key proteins involved in glucocorticoid activity and insulin signaling; microtubule-associated protein tau phosphorylation, and neuronal and synaptic function markers. |
2021-08-04 |
2023-01-26 |
mouse |
| Jos\\xc3\\xa9 Gulfo, Joana P\\xc3\\xa9rez de San Rom\\xc3\\xa1n, Angelo Ledda, Felix Junyent, Mar\\xc3\\xada J Ram\\xc3\\xadrez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3\\xce\\xb2 and phosphorylated-Tau levels in the hippocampus. PloS one vol 16 issue 2 2021 33592009 |
our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished fk506 binding protein 5 expression, increased corticosterone downstream effectors and altered mapk and pi3k pathway with increased py216-gsk3\xce\xb2 and phosphorylated tau. |
2021-08-04 |
2023-01-26 |
mouse |
| Sujin Kim, Yunkwon Nam, Min-Joo Ham, Chisoo Park, Minho Moon, Doo-Han Yo. Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review. Frontiers in aging neuroscience vol 13 issue 2021 34335229 |
this review postulates potential neurological mechanisms of emotional or social interaction through aai in countering ad-related pathologies, such as a\xce\xb2 deposition, tau hyperphosphorylation, neuroinflammation, and impaired adult hippocampal neurogenesis (ahn), and proposes insights for future research by organizing accumulated previous evidence. |
2021-08-03 |
2023-01-26 |
Not clear |
| Mara A Guzm\\xc3\\xa1n-Ruiz, Amor Herrera-Gonz\\xc3\\xa1lez, Adriana Jim\\xc3\\xa9nez, Alan Candelas-Ju\\xc3\\xa1rez, Crystal Quiroga-Lozano, Claudia Castillo-D\\xc3\\xadaz, Erika Orta-Salazar, Diana Organista-Ju\\xc3\\xa1rez, Sof\\xc3\\xada D\\xc3\\xadaz-Cintra, Rosalinda Guevara-Guzm\\xc3\\xa1. Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid \\xce\\xb2 BMC neuroscience vol 22 issue 1 2021 33653273 |
studies have demonstrated that apn administration decreases a\xce\xb2 neurotoxicity and tau hyperphosphorylation in the hipp, reducing cognitive impairment. |
2021-07-31 |
2023-01-26 |
Not clear |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN vol 70 issue 11 2021 32372343 |
quantitative assessment of hippocampal tau pathology in ad and part. |
2021-07-29 |
2023-01-26 |
Not clear |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN vol 70 issue 11 2021 32372343 |
to quantitatively assess the distribution pattern of hippocampal tau pathology in alzheimer's disease (ad) and primary age-related tauopathy (part), we investigated the distribution of phosphorylated tau protein (at8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in part and ad. |
2021-07-29 |
2023-01-26 |
Not clear |
| Karlo Toljan, Jan Homola. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities. Handbook of clinical neurology vol 179 issue 2021 34225969 |
the understanding of alzheimer's disease (ad) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, insulin resistance, and circadian rhythm alterations. |
2021-07-28 |
2023-01-26 |
Not clear |
| Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo Le\\xc3\\xb3n-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications vol 1 issue 1 2021 34296096 |
morphological alterations have been described in hippocampal dendritic spines during hibernation-a state of inactivity and metabolic depression that occurs via a transient neuronal tau hyperphosphorylation. |
2021-07-24 |
2023-01-26 |
Not clear |
| Ida Cariati, Laura Masuelli, Roberto Bei, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangel. Neurodegeneration in Niemann-Pick Type C Disease: An Updated Review on Pharmacological and Non-Pharmacological Approaches to Counteract Brain and Cognitive Impairment. International journal of molecular sciences vol 22 issue 12 2021 34202978 |
in addition, different pathological similarities, including degeneration of hippocampal and cortical neurons, hyperphosphorylated tau, and neurofibrillary tangle formation, have been identified between npc disease and other neurodegenerative pathologies. |
2021-07-20 |
2023-01-26 |
Not clear |
| Yanyan Kong, Lin Huang, Weihao Li, Xuanting Liu, Yinping Zhou, Cuiping Liu, Shibo Zhang, Fang Xie, Zhengwei Zhang, Donglang Jiang, Weiyan Zhou, Ruiqing Ni, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Gua. The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment. Frontiers in cell and developmental biology vol 9 issue 2021 34277597 |
we found that the expression of sv2a was down-regulated in the hippocampus of ad patients, yet the relation of sv2a to other hallmarks of ad pathology such as amyloid precursor protein (app), \xce\xb2-amyloid (a\xce\xb2), and tau protein is not thoroughly clear. |
2021-07-20 |
2023-01-26 |
Not clear |