| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Viridiana Navarrete-Yañez, Alejandra Garate-Carrillo, Alonso Rodriguez, Patricia Mendoza-Lorenzo, Guillermo Ceballos, Claudia Calzada-Mendoza, Michael C Hogan, Francisco Villarreal, Israel Ramirez-Sanche. Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. Food & function. vol 11. issue 12. 2021-06-01. PMID:33201160. |
in the present study using the same mouse model of aging, we examined the capacity of epi to mitigate hippocampus os, inflammation, hyperphosphorylation of tau protein, soluble β-amyloid protein levels, cell survival, memory, anxiety-like behavior levels and systemic inflammation. |
2021-06-01 |
2023-08-13 |
mouse |
| Helen C Murray, Birger Victor Dieriks, Molly E V Swanson, Praju Vikas Anekal, Clinton Turner, Richard L M Faull, Leonardo Belluscio, Alan Koretsky, Maurice A Curti. The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665027. |
we used immunohistochemistry to label two markers of upr activation (p-perk and p-eif2α) concomitantly with neuronal markers (neun and pgp9.5) and pathology markers (beta-amyloid and tau) in the olfactory bulb, piriform cortex, entorhinal cortex and the ca1 region of the hippocampus in ad and normal cases. |
2021-05-31 |
2023-08-13 |
Not clear |
| Miao Zhang, Shangxin Song, Di Zhao, Jie Shi, Xinglian Xu, Guanghong Zhou, Chunbao L. High intake of chicken and pork proteins aggravates high-fat-diet-induced inflammation and disorder of hippocampal glutamatergic system. The Journal of nutritional biochemistry. vol 85. 2021-05-31. PMID:32827667. |
a high-chicken-protein diet significantly increased the levels of systemic inflammatory factors, tau protein and amyloid precursor protein mrna level in the rat hippocampus. |
2021-05-31 |
2023-08-13 |
rat |
| Daniela Monteiro-Fernandes, Joana Margarida Silva, Carina Soares-Cunha, Christina Dalla, Nikolaos Kokras, François Arnaud, Rodolphe Billiras, Viktoriya Zhuravleva, Clarissa Waites, Sylvie Bretin, Nuno Sousa, Ioannis Sotiropoulo. Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology. Molecular psychiatry. 2021-05-28. PMID:32467647. |
furthermore, pam-ampa treatment reverted stress/aβ-driven synaptic missorting of tau and associated fyn/glun2b-driven excitotoxic synaptic signaling accompanied by recovery of neurotransmitter levels in the hippocampus. |
2021-05-28 |
2023-08-13 |
Not clear |
| Florian Eckenweber, Jose Medina-Luque, Tanja Blume, Christian Sacher, Gloria Biechele, Karin Wind, Maximilian Deussing, Nils Briel, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Marcus Unterrainer, Nathalie L Albert, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Paul Cumming, Axel Rominger, Günter U Höglinger, Jochen Herms, Matthias Brende. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32660586. |
p301s tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. |
2021-05-24 |
2023-08-13 |
mouse |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
primary hippocampal wildtype or βapp-tau silenced cells were co-treated with pq with or without e2, n-acetylcysteine (nac), ns-398 (cyclooxygenase-2 inhibitor), mf63 (pges-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (bdnf) during one- and fourteen-days to studied pq effect on prostaglandin e2 (pge2) and bdnf signaling and their involvement in hyperphosphorylated tau (ptau) and amyloid-beta (aβ) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by pq. |
2021-05-21 |
2023-08-13 |
Not clear |
| Kurt A Jellinge. Pathobiological Subtypes of Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 49. issue 4. 2021-05-21. PMID:33429401. |
in addition to the 4 major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy [ma]), several other clinical variants showing distinct regional patterns of tau burden have been identified: nonamnestic, corticobasal syndromal, primary progressive aphasia, posterior cortical atrophy, behavioral/dysexecutive, and mild dementia variants. |
2021-05-21 |
2023-08-13 |
Not clear |
| Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. |
the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. |
2021-05-18 |
2023-08-13 |
mouse |
| Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zhen. Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649817. |
immunohistochemical analysis revealed that rg1 decreased the expression of amyloid β, tau phosphorylated at serine 404 and pro-apoptotic factor bax, while increasing the expression of bcl-2 in the hippocampus and cortex. |
2021-05-17 |
2023-08-13 |
Not clear |
| Ari Loren Mendell, Samantha D Creighton, Hayley A Wilson, Kristen H Jardine, Lauren Isaacs, Boyer D Winters, Neil J MacLusk. Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice. Neuroscience. vol 429. 2021-05-14. PMID:31954826. |
inhibition of 5α reductase impairs cognitive performance, alters dendritic morphology and increases tau phosphorylation in the hippocampus of male 3xtg-ad mice. |
2021-05-14 |
2023-08-13 |
mouse |
| D Monteiro-Fernandes, N Sousa, O F X Almeida, I Sotiropoulo. Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain. Neuroscience. vol 454. 2021-05-14. PMID:32512138. |
we here report that both, long-term gc deprivation (by adrenalectomy) and exogenous gc administration with natural or synthetic glucocorticoid receptor ligands (corticosterone and dexamethasone, respectively) induce tau hyperphosphorylation in the hippocampus and frontocortical regions at epitopes associated with disruption of cytoskeletal and synaptic function. |
2021-05-14 |
2023-08-13 |
rat |
| Wen Yang, Yue Liu, Qing-Qing Xu, Yan-Fang Xian, Zhi-Xiu Li. Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3 Oxidative medicine and cellular longevity. vol 2020. 2021-05-14. PMID:32963694. |
sulforaphene ameliorates neuroinflammation and hyperphosphorylated tau protein via regulating the pi3k/akt/gsk-3 alzheimer's disease (ad) is the most common form of dementia characterized by progressive loss of cognitive functions due to neuronal death mainly in the hippocampal and cortical brain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J Czuczwa. Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671097. |
participation of amyloid and tau protein in post-ischemic neurodegeneration of the hippocampus of a nature identical to alzheimer's disease. |
2021-05-12 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J Czuczwa. Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671097. |
recent evidence suggests that amyloid and tau protein are of vital importance in post-ischemic death of ca1 pyramidal neurons of the hippocampus. |
2021-05-12 |
2023-08-13 |
Not clear |
| Connor M Wander, Jui-Heng Tseng, Sheng Song, Heba A Al Housseiny, Dalton S Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B Meeker, David J Irwin, Todd J Cohe. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. vol 23. issue 7. 2021-05-11. PMID:32585593. |
the accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging. |
2021-05-11 |
2023-08-13 |
mouse |
| Cheng Xu, Jing Guo, Li Li, Xin Wang, Qiuzhi Zhou, Dongsheng Sun, Shujuan Zhang, Shihong Li, Jinwang Ye, Yanchao Liu, Enjie Liu, Peng Zeng, Xiaochuan Wang, Ying Yang, Jian-Zhi Wan. Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies. Journal of Alzheimer's disease : JAD. vol 73. issue 3. 2021-05-10. PMID:31884489. |
here, we co-expressed three isoforms of human wild-type 3r-tau in adult mouse hippocampal to mimic the pathologic tau accumulating observed in pid patients. |
2021-05-10 |
2023-08-13 |
mouse |
| Michael G Friedrich, Amanda Skora, Sarah E Hancock, Todd W Mitchell, Paul L Else, Roger J W Truscot. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International journal of molecular sciences. vol 22. issue 7. 2021-05-10. PMID:33805376. |
antibodies to the c-terminal and n-terminal regions of tau were employed to examine tau cleavage in five human brain regions: the entorhinal cortex, prefrontal cortex, motor cortex, hippocampus, and cerebellum. |
2021-05-10 |
2023-08-13 |
human |
| Graciela Muniz Terrera, John E Harrison, Craig W Ritchie, Karen Ritchi. Cognitive Functions as Predictors of Alzheimer's Disease Biomarker Status in the European Prevention of Alzheimer's Dementia Cohort. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144988. |
these preliminary findings suggest that profiles of cognitive performance may be specific to a given biomarker, with a primarily hippocampal task being associated with higher levels of tau and a frontal executive task being associated with higher levels of aβ. |
2021-05-07 |
2023-08-13 |
human |
| Marangelie Criado-Marrero, Niat T Gebru, Lauren A Gould, Danielle M Blazier, Yamile Vidal-Aguiar, Taylor M Smith, Salma S Abdelmaboud, Lindsey B Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A Dickey, Laura J Blai. FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. NPJ aging and mechanisms of disease. vol 7. issue 1. 2021-05-07. PMID:33941782. |
to test this, tau transgenic (rtg4510) and wild-type mice received bilateral hippocampal injections of virus overexpressing fkbp52 or gfp control. |
2021-05-07 |
2023-08-13 |
mouse |
| Michael Ohene-Nyako, Sara R Nass, Yun K Hahn, Pamela E Knapp, Kurt F Hause. Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice. Neuroscience letters. vol 741. 2021-05-04. PMID:33202259. |
the pathological phospho-isotypes of tau (pser396, pser404, pthr205, pser202, and pthr181) and the tau kinases gsk3β and cdk5/p35 were explored in the striatum, hippocampus, and prefrontal cortex of inducible male and female hiv-1 tat-transgenic mice, with some receiving escalating doses of morphine for 2 weeks. |
2021-05-04 |
2023-08-13 |
mouse |