| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiqu Xu, Hui Gao, Li Zhang, Shuang Rong, Wei Yang, Congcong Ma, Meng Chen, Qingde Huang, Qianchun Deng, Fenghong Huan. Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. Journal of pineal research vol 67 issue 2 2020 31050371 |
melatonin also prevented hfd-induced increases in beta-amyloid (a\xce\xb2) accumulation and tau phosphorylation in the hippocampus. |
2020-01-09 |
2023-01-26 |
rat |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
differential accumulation of tau phosphorylated at residues thr231, ser262 and thr205 in hippocampal interneurons and its modulation by tau mutations (vlw) and amyloid-\xce\xb2 peptide. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
here we demonstrate that, in vlw mice, the accumulation of human p-tau in pyramidal cells induces the phosphorylation of murine tau at residue thr231 in hippocampal interneurons. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
in addition, we show that pser262 and pthr205 tau are present specifically in the soma of some hippocampal interneurons in control mice. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
analysis of j20 mice-a model that accumulates a\xce\xb2-and of vlw animals showed that the density of hippocampal interneurons accumulating pthr205 tau is lower in vlw mice than in controls. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
in contrast, the density of interneurons accumulating pthr205 tau in j20 mice was increased compared to controls in hippocampal regions with a higher a\xce\xb2 plaque load, thereby suggesting that pthr205 tau is induced by a\xce\xb2. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
no significant differences were found between the density of hippocampal interneurons positive for pser262 tau in vlw or j20 mice compared to control animals. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
we also show that pser262 and pthr205 tau are present in the soma of some hippocampal interneurons containing parvalbumin, calbindin or calretinin in control, vlw, and j20 mice. |
2019-12-16 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Georgina Targa-Fabra, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-\\xce\\xb2 peptide. Neurobiology of disease vol 125 issue 2019 30553886 |
taken together, these data point to a specific role of pser262 and pthr205 tau in the soma of hippocampal interneurons in control and pathological conditions. |
2019-12-16 |
2023-01-26 |
mouse |
| Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aur\\xc3\\xa9lie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blu. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiology of disease vol 125 issue 2019 30665005 |
using electrophysiological and biochemical evaluations, we surprisingly observed that, at a time when tau pathology and cognitive deficits are overt and obvious, the hippocampus of thy-tau22 mice exhibits enhanced response to insulin. |
2019-12-16 |
2023-01-26 |
mouse |
| Sheng-Jun Fan, Fang-I Huang, Jing-Ping Liou, Chia-Ron Yan. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model. Cell death & disease vol 9 issue 6 2019 29844403 |
the primary pathological features of ad include senile plaques (sps) and intracellular neurofibrillary tangles (nfts), comprising aggregated amyloid \xce\xb2 (a\xce\xb2) and hyperphosphorylated tau protein, respectively, in the hippocampus of ad patients. |
2019-12-10 |
2023-01-26 |
Not clear |
| Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qi. The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats. Biochemical and biophysical research communications vol 510 issue 1 2019 30660367 |
gv promoted tau phosphorylation and inhibited the akt/gsk3\xce\xb2 pathway in the hippocampus. |
2019-11-29 |
2023-01-26 |
rat |
| Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qi. The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats. Biochemical and biophysical research communications vol 510 issue 1 2019 30660367 |
in conclusion, the present study highlighted that gv might induce diabetic central neuropathy through the hyperphosphorylation of tau in the hippocampus by inhibiting the akt/gsk3\xce\xb2 pathway and that it may cause dpn through oxidative stress and inflammatory responses by activating the nf-\xce\xbab pathway. |
2019-11-29 |
2023-01-26 |
rat |
| Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget vol 8 issue 42 2019 29069820 |
we confirmed that grk5 translocates from the cellular membrane to the cytosol in the hippocampus of alzheimer's disease mice and that grk5 deficiency promotes tau hyperphosphorylation, a hallmark of alzheimer's disease pathology. |
2019-11-20 |
2023-01-26 |
Not clear |
| S Tomaszewski, S Gauthier, A Wimo, P Rosa-Net. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer's Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. The journal of prevention of Alzheimer's disease vol 3 issue 3 2019 29205255 |
patients with alzheimer's disease (ad) are known to have characteristic pathology, including senile plaques with amyloid beta-protein aggregates and neurofibrillary tangles with assembled tau proteins, which start in the hippocampus and spread to neighboring areas. |
2019-11-20 |
2023-01-26 |
Not clear |
| Stanislav Sutovsky, Tomas Smolek, Peter Turcani, Robert Petrovic, Petra Brandoburova, Santosh Jadhav, Petr Novak, Johannes Attems, Norbert Zilk. Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn. Journal of neural transmission (Vienna, Austria : 1996) vol 125 issue 6 2019 29404783 |
in the neocortex, tau pathology, especially neuropil threads, was more abundant in the frontal and occipital cortex and in the hippocampus. |
2019-11-12 |
2023-01-26 |
human |
| Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Ma\\xc3\\xafza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one vol 14 issue 1 2019 30608949 |
glycosaminoglycans from alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. |
2019-11-04 |
2023-01-26 |
Not clear |
| Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Ma\\xc3\\xafza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one vol 14 issue 1 2019 30608949 |
here, we show that total sulfated gags from hippocampus of alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including fgf-2, vegf, and bdnf while their capacity to bind to tau is remarkable increased. |
2019-11-04 |
2023-01-26 |
Not clear |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports vol 8 issue 1 2019 30279527 |
chronic noise exposure led to progressive overproduction of a\xce\xb2 and increased the hyperphosphorylation of tau at ser396, thr205, and thr231 sites in the hippocampus and the prefrontal cortex (pfc) in young samp8 mice, similar to that observed in aging samp8 mice. |
2019-10-31 |
2023-01-26 |
mouse |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports vol 8 issue 1 2019 30279527 |
these findings demonstrate that chronic noise stress exacerbated ad-like neuropathology, possibly by disrupting wnt signaling and triggering aberrant tau hyperphosphorylation and a\xce\xb2 in the pfc and hippocampus. |
2019-10-31 |
2023-01-26 |
mouse |