| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
following partial hepatectomy, the levels of phosphorylated mtor, phosphorylated 70s6k, and phosphorylated tau were all increased in the hippocampus. |
2020-11-17 |
2023-08-13 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
rapamycin treatment restored autophagy function, attenuated phosphorylation of tau protein, and increased bdnf and synaptophysin expression in the hippocampus of surgical mice. |
2020-11-17 |
2023-08-13 |
mouse |
| Mona Khalifa, Marwa M Safar, Rania M Abdelsalam, Hala F Zak. Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats. Neurotoxicity research. vol 37. issue 2. 2020-11-12. PMID:31332715. |
it reversed the increase in hippocampal amyloid beta protein, phosphorylated tau protein contents together with augmentation of neprilysin level, it also diminished levels of nuclear factor kappa-b, fas ligand, tumor necrosis factor-alpha, malondialdehyde, and acetylcholinesterase content.these findings show the protective action of telmisartan against ad-like pathological alterations. |
2020-11-12 |
2023-08-13 |
rat |
| Yanchong Zhang, Feng Wu, Khalid Iqbal, Cheng-Xin Gong, Wen Hu, Fei Li. Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Scientific reports. vol 9. issue 1. 2020-11-10. PMID:30846870. |
we detected hyperphosphorylation of tau at multiple sites in ipsilateral hippocampus 6 weeks but not 7 months after cci. |
2020-11-10 |
2023-08-13 |
mouse |
| Marzena Ułamek-Kozioł, Stanisław Jerzy Czuczwar, Sławomir Januszewski, Ryszard Plut. Proteomic and Genomic Changes in Tau Protein, Which Are Associated with Alzheimer's Disease after Ischemia-Reperfusion Brain Injury. International journal of molecular sciences. vol 21. issue 3. 2020-11-09. PMID:32019137. |
data show that brain ischemia activates neuronal changes and death in the hippocampus in a manner dependent on tau protein, thus determining a new and important way to regulate the survival and/or death of post-ischemic neurons. |
2020-11-09 |
2023-08-13 |
Not clear |
| Arnaud Charil, Sergey Shcherbinin, Sudeepti Southekal, Michael D Devous, Mark Mintun, Melissa E Murray, Bradley B Miller, Adam J Schwar. Tau Subtypes of Alzheimer's Disease Determined in vivo Using Flortaucipir PET Imaging. Journal of Alzheimer's disease : JAD. vol 71. issue 3. 2020-11-05. PMID:31476153. |
worse performance on delayed recall was associated with increased hippocampal tau signal, and worse performance on the trail making test b-a was associated with lower values of the hippocampus to cortex ratio. |
2020-11-05 |
2023-08-13 |
human |
| Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. [Neuroprotective effects of the peel of Citrus kawachiensis (Kawachi Bankan) and auraptene in the hippocampus of hyperglycemia mice and global cerebral ischemia/reperfusion injury mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 4. 2020-11-02. PMID:32612031. |
the c. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the type 2 diabetic db/db mice. |
2020-11-02 |
2023-08-13 |
mouse |
| Océane Guillemaud, Kelly Ceyzériat, Thomas Saint-Georges, Karine Cambon, Fanny Petit, Lucile Ben Haim, Maria-Angeles Carrillo-de Sauvage, Martine Guillermier, Sueva Bernier, Anne-Sophie Hérard, Charlène Joséphine, Alexis Pierre Bémelmans, Emmanuel Brouillet, Philippe Hantraye, Gilles Bonvento, Carole Escarti. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiology of aging. vol 90. 2020-10-29. PMID:32171592. |
we aimed to evaluate whether reactive astrocytes contribute to tau as well as amyloid pathologies in the hippocampus of 3xtg-ad mice, an ad model that develops tau hyper-phosphorylation and amyloid deposition. |
2020-10-29 |
2023-08-13 |
mouse |
| Océane Guillemaud, Kelly Ceyzériat, Thomas Saint-Georges, Karine Cambon, Fanny Petit, Lucile Ben Haim, Maria-Angeles Carrillo-de Sauvage, Martine Guillermier, Sueva Bernier, Anne-Sophie Hérard, Charlène Joséphine, Alexis Pierre Bémelmans, Emmanuel Brouillet, Philippe Hantraye, Gilles Bonvento, Carole Escarti. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiology of aging. vol 90. 2020-10-29. PMID:32171592. |
jak2-stat3 pathway-mediated modulation of reactive astrocytes in 25% of the hippocampus of 3xtg-ad mice did not significantly influence tau phosphorylation or amyloid processing and deposition at early, advanced, and terminal disease stage. |
2020-10-29 |
2023-08-13 |
mouse |
| Anna L Svenningsson, Erik Stomrud, Philip S Insel, Niklas Mattsson, Sebastian Palmqvist, Oskar Hansso. β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31371787. |
using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-β (aβ42/40), neuroinflammation (ykl-40), and neurodegeneration and tau pathology (t-tau and p-tau) as well as mri measures of white-matter lesions, hippocampal volume (hv), and regional cortical thickness. |
2020-10-27 |
2023-08-13 |
human |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer's disease. Human molecular genetics. vol 29. issue 2. 2020-10-19. PMID:31814000. |
we analyzed the animals' memory function, hippocampal ca2+ levels and amyloid-β (aβ) and tau pathologies when they were 12 months old. |
2020-10-19 |
2023-08-13 |
mouse |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer's disease. Human molecular genetics. vol 29. issue 2. 2020-10-19. PMID:31814000. |
we found that compared with 3xtg-ad-/-/trpv1+/+ mice, 3xtg-ad+/+/trpv1+/+ mice had memory impairment and increased levels of hippocampal ca2+, aβ and total and phosphorylated tau. |
2020-10-19 |
2023-08-13 |
mouse |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer's disease. Human molecular genetics. vol 29. issue 2. 2020-10-19. PMID:31814000. |
however, 3xtg-ad+/+/trpv1-/- mice had better memory function and lower levels of hippocampal ca2+, aβ, tau and p-tau, compared with 3xtg-ad+/+/trpv1+/+ mice. |
2020-10-19 |
2023-08-13 |
mouse |
| Onder Albayram, Bryce MacIver, John Mathai, Anne Verstegen, Sean Baxley, Chenxi Qiu, Carter Bell, Barbara J Caldarone, Xiao Zhen Zhou, Kun Ping Lu, Mark Zeide. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific reports. vol 9. issue 1. 2020-10-15. PMID:31201348. |
hyperphosphorylated tau deposition and neural tangle-like pathology occurred in cortical and hippocampal regions only of igg control mice accompanied with post-traumatic neuroinflammation and was not seen in midbrain and hindbrain regions associated with bladder filling and voiding reflex arcs. |
2020-10-15 |
2023-08-13 |
mouse |
| Beibei Wu, Yujing Wang, Chenggang Shi, Yao Chen, Lexiang Yu, Juan Li, Weiwei Li, Yan Wei, Rongqiao H. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. Journal of Alzheimer's disease : JAD. vol 71. issue 1. 2020-10-13. PMID:31381511. |
injections of rrsa were found to trigger tau hyperphosphorylation in the rat hippocampus via gsk-3β activation. |
2020-10-13 |
2023-08-13 |
rat |
| Dong Jun Sung, Yun-Hee Noh, Jun-Ho Lee, Mingli Jin, Jin-Seoung Kim, Sang-Don Ha. Diet control to achieve euglycaemia induces tau hyperphosphorylation via AMPK activation in the hippocampus of diabetic rats. Food & function. vol 11. issue 1. 2020-10-07. PMID:31799531. |
diet control to achieve euglycaemia induces tau hyperphosphorylation via ampk activation in the hippocampus of diabetic rats. |
2020-10-07 |
2023-08-13 |
rat |
| Dong Jun Sung, Yun-Hee Noh, Jun-Ho Lee, Mingli Jin, Jin-Seoung Kim, Sang-Don Ha. Diet control to achieve euglycaemia induces tau hyperphosphorylation via AMPK activation in the hippocampus of diabetic rats. Food & function. vol 11. issue 1. 2020-10-07. PMID:31799531. |
since ampk is a direct regulator of tau phosphorylation, we hypothesized that strict diet control to achieve euglycaemia affects tau protein phosphorylation through increased ampk activity in the hippocampus of dm rats. |
2020-10-07 |
2023-08-13 |
rat |
| Dong Jun Sung, Yun-Hee Noh, Jun-Ho Lee, Mingli Jin, Jin-Seoung Kim, Sang-Don Ha. Diet control to achieve euglycaemia induces tau hyperphosphorylation via AMPK activation in the hippocampus of diabetic rats. Food & function. vol 11. issue 1. 2020-10-07. PMID:31799531. |
furthermore, the r group showed more critical tau pathology in the hippocampus than the other groups. |
2020-10-07 |
2023-08-13 |
rat |
| Dong Jun Sung, Yun-Hee Noh, Jun-Ho Lee, Mingli Jin, Jin-Seoung Kim, Sang-Don Ha. Diet control to achieve euglycaemia induces tau hyperphosphorylation via AMPK activation in the hippocampus of diabetic rats. Food & function. vol 11. issue 1. 2020-10-07. PMID:31799531. |
these results suggest that diet control to achieve euglycaemia in an insulin-deficient dm condition may be harmful because of the greater possibility of ad development through increased tau phosphorylation by ampk activation in the hippocampus. |
2020-10-07 |
2023-08-13 |
rat |
| Mariana Vargas-Caballero, Franziska Denk, Heike J Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L Oliver, Olivia A Shipton, Ole Paulsen, Richard Wade-Martin. Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28484365. |
we recently reported that aβ-mediated inhibition of hippocampal long-term potentiation (ltp) in mice requires tau. |
2020-10-01 |
2023-08-13 |
mouse |