| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Irene Delgado-Olmos, Carlos Gamero-Carrasco, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloz. Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice. Molecular neurobiology vol 54 issue 6 2018 27443159 |
while mgf did not affect amyloid pathology, tau hyperphosphorylation was significantly reduced in the cortex and hippocampus. |
2018-04-09 |
2023-01-25 |
mouse |
| Xiaoping Du, Matthew B West, Qunfeng Cai, Weihua Cheng, Donald L Ewert, Wei Li, Robert A Floyd, Richard D Kopk. Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure. Free radical biology & medicine vol 108 issue 2018 28438658 |
our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accumulation of neurotoxic variants of the microtubule-associated protein, tau, in the hippocampus. |
2018-04-09 |
2023-01-26 |
rat |
| Annachiara Cagnin, Sara Mariotto, Michele Fiorini, Marina Gaule, Nicola Bonetto, Matteo Tagliapietra, Emanuele Buratti, Gianluigi Zanusso, Sergio Ferrari, Salvatore Monac. Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy. Journal of Alzheimer's disease : JAD vol 59 issue 1 2018 28550263 |
postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal tdp-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain. |
2018-04-06 |
2023-01-26 |
Not clear |
| Gang Wang, Yue Huang, Li-Ling Wang, Yong-Fang Zhang, Jing Xu, Yi Zhou, Guinevere F Lourenco, Bei Zhang, Ying Wang, Ru-Jing Ren, Glenda M Halliday, Sheng-Di Che. MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease. Scientific reports vol 6 issue 2018 27221467 |
intra-hippocampal delivery of a microrna-146a specific inhibitor (antagomir) into 5xfad mice showed enhanced hippocampal levels of rock1 protein and repressed tau hyperphosphorylation, partly restoring memory function in the 5xfad mice. |
2018-04-02 |
2023-01-25 |
mouse |
| Liliana Lozano, Jorge Guevara, Tony Lefebvre, Ivan Ramos-Martinez, Daniel Lim\\xc3\\xb3n, Alfonso D\\xc3\\xadaz, Eduarda Cer\\xc3\\xb3n, Edgar Zenten. Effect of amyloid-\\xce\\x92 (25-35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein. Neuropeptides vol 63 issue 2018 28427866 |
with this in mind, both o-glcnacylation and phosphorylation of tau protein were evaluated in the brain of rats with streptozotocin (stz)-induced hyperglycemia and hyperinsulinemia and treated with the a\xc3\x9f25-35 peptide in the hippocampal region ca1. |
2018-03-26 |
2023-01-26 |
rat |
| Wanda M Snow, Ryan Dale, Zoe O'Brien-Moran, Richard Buist, Danial Peirson, Melanie Martin, Benedict C Albens. In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging. Journal of Alzheimer's disease : JAD vol 58 issue 3 2018 28505976 |
decreased fractional anisotropy (p\xe2\x80\x8a<\xe2\x80\x8a0.01) and axial diffusivity (p\xe2\x80\x8a<\xe2\x80\x8a0.05) were detected only in the hippocampus, in which both congophilic a\xce\xb2 plaques and hyperphosphorylated tau accumulation, consistent with neurofibrillary tangle formation, were detected. |
2018-03-21 |
2023-01-26 |
mouse |
| Jieun Kim, In-Young Choi, Karen E Duff, Phil Le. Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510). Neurochemical research vol 42 issue 6 2018 28523532 |
progressive pathological changes in neurochemical profile of the hippocampus and early changes in the olfactory bulbs of tau transgenic mice (rtg4510). |
2018-03-19 |
2023-01-26 |
Not clear |
| Sergi Borrego-\\xc3\\x89cija, Oriol Grau-Rivera, Mart\\xc3\\xad Colom-Cadena, Jos\\xc3\\xa9 Luis Molinuevo, Eduard Tolosa, Raquel S\\xc3\\xa1nchez-Valle, Ellen Gelp. Tauopathy with Hippocampal 4-Repeat Tau Immunoreactive Spherical Inclusions in a Patient with PSP. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 29516660 |
tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions in a patient with psp. |
2018-03-19 |
2023-01-26 |
Not clear |
| Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Yolanda Marin-Zambrana, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloz. Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model. Brain pathology (Zurich, Switzerland) vol 27 issue 4 2018 27537110 |
cortical and hippocampal atrophy was reduced in db/db mice and tau hyperphosphorylation was lower after mgf treatment, resulting in partial recovery of learning and memory disabilities. |
2018-03-16 |
2023-01-25 |
mouse |
| Xiang-Zhen Yuan, Sen Sun, Chen-Chen Tan, Jin-Tai Yu, Lan Ta. The Role of ADAM10 in Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 58 issue 2 2018 28409746 |
increasing evidence indicates that adam10 not only reduces the generation of a\xce\xb2 but may also affect the pathology of ad through potential mechanisms including reducing tau pathology, maintaining normal synaptic functions, and promoting hippocampal neurogenesis and the homeostasis of neuronal networks. |
2018-03-16 |
2023-01-26 |
Not clear |
| Anna E Blanken, Sona Hurtz, Chris Zarow, Kristina Biado, Hedieh Honarpisheh, Johanne Somme, Jenny Brook, Spencer Tung, Emily Kraft, Darrick Lo, Denise W Ng, Harry V Vinters, Liana G Apostolov. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7\\xc2\\xa0T MRI. NeuroImage. Clinical vol 15 issue 2018 28491492 |
there were subfield specific associations between hippocampal radial distance and tau in ca2, and cresyl violet neuronal counts in ca1 and subiculum. |
2018-03-02 |
2023-01-26 |
human |
| Benjamin Combs, Chelsey Hamel, Nicholas M Kanaa. Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Neurobiology of disease vol 94 issue 2018 27260838 |
we then determined the pattern of tau pathology labeled by each antibody in human hippocampal sections at various disease stages in order to characterize pad exposure in the context of disease progression. |
2018-02-27 |
2023-01-25 |
human |
| Yin Li, Ze-Xu Li, Tan Jin, Zhan-You Wang, Pu Zha. Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. Journal of Alzheimer's disease : JAD vol 57 issue 2 2018 28234253 |
these findings suggest that by abolishing the axonal-localization of has1 and promoting the expression of has3 and the synthesis of shorter-chain ha, the tau pathology breaks the balance of ecm components, promotes the reorganization of the ecm, and inhibits the formation of pnns in the hippocampus, and then regulates neuronal plasticity during the progression of ad. |
2018-02-26 |
2023-01-26 |
human |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior vol 174 issue 2018 28322909 |
current evidences support that inflammatory reaction, oxidative stress, as well as abnormal insulin signaling in the hippocampus are potential causes of tau hyperphosphorylation and finally induce cognitive dysfunction. |
2018-02-26 |
2023-01-26 |
rat |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior vol 174 issue 2018 28322909 |
immunohistochemistry staining also had shown that tau hyperphosphorylation in the hippocampus was prevented after paeoniflorin administration. |
2018-02-26 |
2023-01-26 |
rat |
| Lucia Buccarello, Giuliano Grignaschi, Anna Maria Castaldo, Alessia Di Giancamillo, Cinzia Domeneghini, Roberto Cosimo Melcangi, Tiziana Borsell. Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD vol 56 issue 4 2018 28157099 |
when compared to control mice (ctr), p301l transgenic mice (tg) presented a lower body weight, reduced survival rate, hyperphosphorylated tau, spine injury, and neuronal loss in both cerebral cortex and hippocampus at 15 months of age. |
2018-02-23 |
2023-01-26 |
mouse |
| Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi O Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwak. Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study. Journal of Alzheimer's disease : JAD vol 55 issue 2 2018 27716666 |
recent increases in hippocampal tau pathology in the aging japanese population: the hisayama study. |
2018-02-22 |
2023-01-26 |
Not clear |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD vol 55 issue 3 2018 27767994 |
our results reveal that the loss of bfcns in pre-symptomatic pr5 (p301l) tau transgenic mice results in a\xc2\xa0decrease in hippocampal brain-derived neurotrophic factor levels and reduced trkb receptor activation. |
2018-02-20 |
2023-01-26 |
mouse |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD vol 55 issue 3 2018 27767994 |
however, there was no exacerbation of the levels of phosphorylated tau or its aggregation in the hippocampus of susceptible mice. |
2018-02-20 |
2023-01-26 |
mouse |
| Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD vol 55 issue 3 2018 27767994 |
this suggests that tau pathology is likely to be regulated independently of bfcn degeneration and the corresponding decrease in hippocampal neurotrophin levels, although these features may still contribute to disease etiology. |
2018-02-20 |
2023-01-26 |
mouse |