| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, A\\xce\\xb21-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease vol 31 issue 3 2018 26883430 |
moreover, atorvastatin significantly attenuated a\xce\xb21-42 accumulation and phosphorylation of tau (ser396) in the hippocampus and prefrontal cortex of tg app/ps1 mice. |
2018-01-12 |
2023-01-25 |
mouse |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology vol 39 issue 4 2018 28083916 |
we propose that an increase in tau acetylated on these lysines blocks the expression of long-term potentiation at hippocampal synapses leading to impaired memory in ad. |
2018-01-12 |
2023-01-26 |
Not clear |
| Julia Gerson, Diana L Castillo-Carranza, Urmi Sengupta, Riddhi Bodani, Donald S Prough, Douglas S DeWitt, Bridget E Hawkins, Rakez Kaye. Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice. Journal of neurotrauma vol 33 issue 22 2018 26729399 |
tau oligomer levels increased in the hippocampal injection sites and cerebellum, suggesting that tau oligomers may be responsible for seeding the spread of pathology post-tbi. |
2018-01-10 |
2023-01-25 |
rat |
| FangFang, Hongyan Li, Tingting Qin, Min Li, Shiping M. Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. Metabolic brain disease vol 32 issue 2 2018 27761760 |
meanwhile, thymol improved the cognitive impairments in the morris water maze (mwm) test and decreased hfd-induced a\xce\xb2 deposition and tau hyperphosphorylation in the hippocampus, which may be correlated with the inhibition of hippocampal oxidative stress and inflammation. |
2018-01-05 |
2023-01-26 |
mouse |
| Jee Hyun Yi, Christopher Brown, Garry Whitehead, Thomas Piers, Young Seok Lee, Celia Martinez Perez, Philip Regan, Daniel J Whitcomb, Kwangwook Ch. Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. Pharmacological research vol 121 issue 2018 28416463 |
glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. |
2018-01-05 |
2023-01-26 |
Not clear |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3\\xce\\xb2 promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging vol 57 issue 2018 28609678 |
in this report, we investigated endocrine mechanisms for hippocampal tau phosphorylation in db/db and wild-type mice. |
2018-01-03 |
2023-01-26 |
mouse |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3\\xce\\xb2 promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging vol 57 issue 2018 28609678 |
by separately manipulating peripheral and intrahippocampal corticosterone levels, we determined that hippocampal corticosteroid exposure promotes tau phosphorylation and activates glycogen synthase kinase 3\xce\xb2 (gsk3\xce\xb2). |
2018-01-03 |
2023-01-26 |
mouse |
| Francesco Tamagnini, Darren A Walsh, Jon T Brown, Marie K Bondulich, Diane P Hanger, Andrew D Randal. Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of aging vol 60 issue 2018 28917666 |
hippocampal neurophysiology is modified by a disease-associated c-terminal fragment of tau protein. |
2018-01-03 |
2023-01-26 |
mouse |
| Vega Garc\\xc3\\xada-Escudero, Ricardo Gargini, Patricia Mart\\xc3\\xadn-Maestro, Esther Garc\\xc3\\xada, Ram\\xc3\\xb3n Garc\\xc3\\xada-Escudero, Jes\\xc3\\xbas Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters vol 655 issue 2018 28689927 |
to explain this apparently contradictory result, we studied mapt mrna stoichiometry in coding and non-coding regions, and found that the 3'utr-to-cds ratio was higher in the hippocampus of alzheimer disease patients, with higher tau protein but lower total mrna levels. |
2018-01-01 |
2023-01-26 |
mouse |
| Junjun Sun, Hong Zhou, Feng Bai, Qingguo Ren, Zhijun Zhan. Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice. Oncotarget vol 7 issue 21 2017 27129150 |
however, we did not observe the increased expression of beta amyloid, hyperphosphorylation of tau and loss of neurons in demyelinated hippocampus. |
2017-12-29 |
2023-01-25 |
mouse |
| Diana Miszczuk, Konrad J D\\xc4\\x99bski, Heikki Tanila, Katarzyna Lukasiuk, Asla Pitk\\xc3\\xa4ne. Traumatic Brain Injury Increases the Expression of Nos1, A\\xce\\xb2 Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease. Molecular neurobiology vol 53 issue 10 2017 26671618 |
to elaborate the mechanisms of worsening outcomes, we studied changes in the expression of genes involved in app processing and tau pathways in the perilesional cortex, ipsilateral thalamus, and ipsilateral hippocampus 16\xc2\xa0weeks post-tbi. |
2017-12-22 |
2023-01-25 |
mouse |
| Denglei Ma, Yanqiu Zhu, Yanzheng Li, Cuicui Yang, Li Zhang, Yali Li, Lin Li, Lan Zhan. Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages. Behavioural brain research vol 312 issue 2017 27283974 |
in addition, cig treatment inhibited tau hyperphosphorylation in the hippocampus and striatum of samp8 mice at different ages. |
2017-12-19 |
2023-01-25 |
mouse |
| Lijuan Shi, Zhihua Zhang, Lin Li, Christian H\\xc3\\xb6lsche. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behavioural brain research vol 327 issue 2017 28342971 |
once-daily for 14days after stz intracerebroventricular (icv) administration significantly prevented spatial learning deficits in a y- maze test and morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus. |
2017-12-19 |
2023-01-26 |
rat |
| Aur\\xc3\\xa9lie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research vol 312 issue 2017 27343935 |
we investigated the effects of a high fat/high cholesterol (hfhc) diet on cognitive performance, neuroinflammation markers, and phosphorylated tau (p-tau) pathological markers in the hippocampus of young (4-month old) versus aged (14-month old) male rats. |
2017-12-13 |
2023-01-25 |
rat |
| Aur\\xc3\\xa9lie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research vol 312 issue 2017 27343935 |
western blot analysis of the hippocampus showed higher levels of p-tau s202/t205 and t231 in aged hfhc rats, suggesting abnormal phosphorylation of tau protein following the hfhc diet exposure. |
2017-12-13 |
2023-01-25 |
rat |
| Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research vol 323 issue 2017 28163095 |
given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. |
2017-12-13 |
2023-01-26 |
mouse |
| Kayla Raider, Delin Ma, Janna L Harris, Isabella Fuentes, Robert S Rogers, Joshua L Wheatley, Paige C Geiger, Hung-Wen Yeh, In-Young Choi, William M Brooks, John A Stanfor. A high fat diet\\xc2\\xa0alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochemistry international vol 97 issue 2017 27125544 |
hippocampal pampk levels correlated significantly with tcr, aspartate (asp), phosphoethanolamine (pe), and taurine (tau), indicating beneficial effects of ampk activation on brain metabolic and energetic function, membrane turnover, and edema. |
2017-12-12 |
2023-01-25 |
rat |
| Sofia Lopes, Jo\\xc3\\xa3o Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America vol 113 issue 26 2017 27274066 |
here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of tau and enhanced fyn/glun2b-driven synaptic signaling. |
2017-12-12 |
2023-01-25 |
mouse |
| Sofia Lopes, Jo\\xc3\\xa3o Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America vol 113 issue 26 2017 27274066 |
in contrast, mice lacking tau [tau knockout (tau-ko) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. |
2017-12-12 |
2023-01-25 |
mouse |
| Elliott J Mufson, Milos D Ikonomovic, Scott E Counts, Sylvia E Perez, Michael Malek-Ahmadi, Stephen W Scheff, Stephen D Ginsber. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioural brain research vol 311 issue 2017 27185734 |
in this review, we illustrate relevant clinical pathological research in preclinical ad and throughout the progression of dementia in several areas including a\xce\xb2 and tau pathobiology, single population expression profiling of vulnerable hippocampal and basal forebrain neurons, neuroplasticity, neuroimaging, cerebrospinal fluid (csf) biomarker studies and their correlation with antemortem cognitive endpoints. |
2017-12-05 |
2023-01-25 |
Not clear |