| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tahir Ali, Myeong Ok Ki. Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3\\xce\\xb2 pathway in the mouse hippocampus. Journal of pineal research vol 59 issue 1 2016 25858697 |
a\xce\xb21-42-injection triggered memory impairment, synaptic disorder, hyperphosphorylation of tau protein, and neurodegeneration in the mice hippocampus. |
2016-05-09 |
2023-01-25 |
mouse |
| Gang Liu, Chao Liu, Xue-Ning Zhan. Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular medicine reports vol 12 issue 3 2016 25998151 |
tau protein hyperphosphorylation in the hippocampus was upregulated by ect, but was reduced by 2,6\xe2\x80\x91diisopropylphenol and the mk\xe2\x80\x91801 nmda receptor antagonist. |
2016-05-03 |
2023-01-25 |
rat |
| Joannee Zumkehr, Carlos J Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazaw. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiology of aging vol 36 issue 7 2016 25964214 |
here, we find the temporal decrease in glt-1 levels in the hippocampus of the 3xtg-ad mouse model and that the pharmacological upregulation of glt-1 significantly ameliorates the age-dependent pathological tau accumulation, restores synaptic proteins, and rescues cognitive decline with minimal effects on a\xce\xb2 pathology. |
2016-04-26 |
2023-01-25 |
Not clear |
| Peng Liu, Jennifer B Paulson, Colleen L Forster, Samantha L Shapiro, Karen H Ashe, Kathleen R Zah. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique \\xce\\xb2-Amyloid Oligomer Profile. PloS one vol 10 issue 5 2016 25946042 |
histologically, we showed that (1) a\xce\xb2 plaques emerged in cerebral cortex and hippocampus as early as 8 and 10.5-12.5 months of age, respectively; (2) plaque deposition progressed in an age-dependent manner, occupying up to 19% of cortex at ~25 months of age; and (3) neuropathology--such as abnormal neuronal architecture, tau hyperphosphorylation and misfolding, and neuroinflammation--was observed in the vicinity of neuritic plaques. |
2016-04-25 |
2023-01-25 |
mouse |
| Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sep\\xc4\\x8di\\xc4\\x87, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS vol 72 issue 23 2016 26070304 |
collectively, these data validate a novel model of locally infused recombinant htau protein as an inducer of tau pathology in the hippocampus of normal rats; future studies will provide insights into the pathological spread and maturation of tau pathology. |
2016-04-25 |
2023-01-25 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases \\xce\\xb2-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport vol 26 issue 12 2016 26164461 |
lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases \xce\xb2-amyloid and phosphorylated tau in the hippocampus in rats. |
2016-04-20 |
2023-01-25 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases \\xce\\xb2-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport vol 26 issue 12 2016 26164461 |
this study was carried out to examine the effects of ltg on cognitive dysfunction, \xce\xb2-amyloid1-42 accumulation, and tau protein hyperphosphorylation in the hippocampus of ischemic rats. |
2016-04-20 |
2023-01-25 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases \\xce\\xb2-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport vol 26 issue 12 2016 26164461 |
moreover, ltg reduced \xce\xb2-amyloid1-42 and phosphorylated tau (at8) in the hippocampus after ischemia. |
2016-04-20 |
2023-01-25 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases \\xce\\xb2-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport vol 26 issue 12 2016 26164461 |
these results suggested that the cognition-protective effects of ltg after cerebral ischemia might involve inhibition of toxic \xce\xb2-amyloid accumulation and tau hyperphosphorylation in the hippocampus. |
2016-04-20 |
2023-01-25 |
rat |
| Qin Ma, Ying-ying Ruan, Hui Xu, Xiao-meng Shi, Zhi-xiang Wang, Yan-li H. Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid \\xce\\xb2-induced impairment of learning and memory in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 76 issue 2016 26653563 |
pathological analysis also showed that sy treatment inhibited the morphological alteration of neurons and tau hyperphosphorylation induced by amyloid \xce\xb2 (1-42)-injection in the cortex and hippocampus. |
2016-04-12 |
2023-01-25 |
rat |
| Robert A Whittington, L\\xc3\\xa1szl\\xc3\\xb3 Vir\\xc3\\xa1g, Maud Gratuze, Franck R Petry, Anastasia No\\xc3\\xabl, Isabelle Poitras, Geoffrey Truchetti, Fran\\xc3\\xa7ois Marcouiller, Marie-Am\\xc3\\xa9lie Papon, Noura El Khoury, Kevin Wong, Alexis Bretteville, Fran\\xc3\\xa7oise Morin, Emmanuel Plane. Dexmedetomidine increases tau phosphorylation under normothermic conditions in\\xc2\\xa0vivo and in\\xc2\\xa0vitro. Neurobiology of aging vol 36 issue 8 2016 26058840 |
when administered to nontransgenic mice, dex-induced tau hyperphosphorylation persisting up to 6\xc2\xa0hours in the hippocampus for the at8 epitope. |
2016-03-17 |
2023-01-25 |
mouse |
| Edward Rockenstein, Cassia R Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquert, Margarita Trejo-Morales, Brian Spencer, Eliezer Maslia. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PloS one vol 10 issue 3 2016 25803611 |
by immunocytochemistry, mice from line 13 displayed extensive accumulation of 3r tau in neuronal cells bodies in the pyramidal neurons of the neocortex, ca1-3 regions, and dentate gyrus of the hippocampus. |
2016-02-22 |
2023-01-25 |
mouse |
| Jerry B Hunt, Kevin R Nash, Devon Placides, Peter Moran, Maj-Linda B Selenica, Firas Abuqalbeen, Kevin Ratnasamy, Nina Slouha, Santiago Rodriguez-Ospina, Miloni Savlia, Yashobha Ranaweera, Patrick Reid, Chad A Dickey, Rodrigo Uricia, Clement G Y Yang, Leslie A Sandusky, Marcia N Gordon, Dave Morgan, Daniel C Le. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 35 issue 44 2016 26538654 |
arg1 overexpression also mitigated hippocampal atrophy in tau transgenic mice. |
2016-02-12 |
2023-01-25 |
mouse |
| Zhi-Hong Hu, Ling-Ling Fan, Yong-Mei H. [Effect of sodium nitrite on phosphorylation of cytoskeletal proteins and spatial learning and memory in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 67 issue 5 2016 26490065 |
phosphorylation level of tau and neurofilament, and the expression of protein phosphatase 2a (pp2a) catalytic subunit in the hippocampus were detected by immunohistochemistry and western blot. |
2016-02-10 |
2023-01-25 |
rat |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian K\\xc3\\xbcgler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience vol 18 issue 11 2016 26436904 |
tau protein spreads from the entorhinal cortex to the hippocampal region early in the disease. |
2016-02-09 |
2023-01-25 |
Not clear |
| Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijania. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PloS one vol 10 issue 5 2016 25933020 |
in a second model, injection of preformed tau fibrils (pffs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young p301s mutant tau over-expressing mice (ps19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. |
2016-02-04 |
2023-01-25 |
mouse |
| Mar Matarin, Dervis A Salih, Marina Yasvoina, Damian M Cummings, Sebastian Guelfi, Wenfei Liu, Muzammil A Nahaboo Solim, Thomas G Moens, Rocio Moreno Paublete, Shabinah S Ali, Marina Perona, Roshni Desai, Kenneth J Smith, Judy Latcham, Michael Fulleylove, Jill C Richardson, John Hardy, Frances A Edward. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell reports vol 10 issue 4 2016 25620700 |
the hippocampal network in tau mice was similar except that trem2 had hub status only in amyloid mice. |
2016-01-28 |
2023-01-25 |
mouse |
| Mar\\xc3\\xada Jos\\xc3\\xa9 Delgado-Cort\\xc3\\xa9s, Ana M Espinosa-Oliva, Manuel Sarmiento, Sandro Arg\\xc3\\xbcelles, Antonio J Herrera, Raquel Mauri\\xc3\\xb1o, Ruth F Villar\\xc3\\xa1n, Jos\\xc3\\xa9 L Venero, Alberto Machado, Roc\\xc3\\xado M de Pablo. Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus. Chemical research in toxicology vol 28 issue 4 2016 25658758 |
we found that chronic stress increases the levels of several proteins involved in alzheimer's disease pathogenesis, such as presenilin 1, presenilin 2, and s100\xce\xb2, besides inducing the aggregation of tau, ubiquitin, and \xce\xb2-amyloid proteins in the hippocampus. |
2016-01-22 |
2023-01-25 |
mouse |
| Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Martina Holubov\\xc3\\xa1, Veronika Nagelov\\xc3\\xa1, Zdenko Pirnik, Jana Zemenov\\xc3\\xa1, Martin Haluz\\xc3\\xadk, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Marie-Christine Galas, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Anorexigenic lipopeptides ameliorate central insulin signaling and attenuate tau phosphorylation in hippocampi of mice with monosodium glutamate-induced obesity. Journal of Alzheimer's disease : JAD vol 45 issue 3 2016 25624414 |
we demonstrated that 6-month-old mice with monosodium glutamate (msg) obesity, which represent a model of obesity-induced pre-diabetes, had increased tau phosphorylation at ser396 and thr231 in the hippocampus compared with the controls, as determined by western blots. |
2016-01-19 |
2023-01-25 |
mouse |
| Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Martina Holubov\\xc3\\xa1, Veronika Nagelov\\xc3\\xa1, Zdenko Pirnik, Jana Zemenov\\xc3\\xa1, Martin Haluz\\xc3\\xadk, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Marie-Christine Galas, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Anorexigenic lipopeptides ameliorate central insulin signaling and attenuate tau phosphorylation in hippocampi of mice with monosodium glutamate-induced obesity. Journal of Alzheimer's disease : JAD vol 45 issue 3 2016 25624414 |
we identified tau hyperphosphorylation in the obesity-induced pre-diabetes state in msg-obese mice and demonstrated the beneficial effects of palm-prrp31 and liraglutide, both of known central anorexigenic effects, on hippocampal insulin signaling and on tau phosphorylation. |
2016-01-19 |
2023-01-25 |
mouse |