| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deirdre Stolmeier, Ramasamy Thangavel, Poojya Anantharam, Mohammad M Khan, Duraisamy Kempuraj, Asgar Zahee. Glia maturation factor expression in hippocampus of human Alzheimer's disease. Neurochemical research. vol 38. issue 8. 2014-02-06. PMID:23640177. |
we further demonstrate that gmf immunoreactive glial cells were increased at the sites of tau containing nfts and aps of hippocampus in ad brains. |
2014-02-06 |
2023-08-12 |
human |
| Harald Lund, Richard F Cowburn, Elin Gustafsson, Kia Strömberg, Anne Svensson, Leif Dahllund, David Malinowsky, Dan Sunnemar. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain pathology (Zurich, Switzerland). vol 23. issue 4. 2014-01-27. PMID:23088643. |
ttbk1 immunoreactivity appeared to vary with the level of phospho-tau staining, and was strong in the somatodendritic compartment of apparently healthy hippocampal neurons as well as in pre-tangle neurons where it co-localized with diffuse phospho-ser422 tau staining. |
2014-01-27 |
2023-08-12 |
human |
| Shoko Morita, Seiji Miyat. Synaptic localization of growth-associated protein 43 in cultured hippocampal neurons during synaptogenesis. Cell biochemistry and function. vol 31. issue 5. 2014-01-21. PMID:23055398. |
double-labelling immunohistochemistry with an axonal marker tau revealed that the immunoreactivity of gap-43 was seen throughout axons of cultured hippocampal neurons but stronger at axonal puncta of developing neurons than axonal processes. |
2014-01-21 |
2023-08-12 |
rat |
| M Oksman, L A Wisman, H Jiang, P Miettinen, D Kirik, H Tanil. Transduced wild-type but not P301S mutated human tau shows hyperphosphorylation in transgenic mice overexpressing A30P mutated human alpha-synuclein. Neuro-degenerative diseases. vol 12. issue 2. 2014-01-17. PMID:22948283. |
to study the relevance and functional implications of these findings in vivo, we transduced hippocampal neurons of wild-type or human a30p α-synuclein transgenic mice with wild-type or p301s mutated human tau using an adeno-associated virus vector. |
2014-01-17 |
2023-08-12 |
mouse |
| Jose J Jarero-Basulto, Jose Luna-Muñoz, Raul Mena, Zdena Kristofikova, Daniela Ripova, George Perry, Lester I Binder, Francisco Garcia-Sierr. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 12. 2014-01-13. PMID:24226268. |
in the hippocampus, we found distinct nonfibrillary aggregates of asp(421)-truncated tau. |
2014-01-13 |
2023-08-12 |
Not clear |
| Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuve. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PloS one. vol 8. issue 5. 2013-12-30. PMID:23704923. |
in particular was nectin-3 depleted from the specific region of the hippocampus, known as the stratum lacunosum and moleculare, in mice that express wild-type or mutant human protein tau, either chronically or sub-acutely. |
2013-12-30 |
2023-08-12 |
mouse |
| Robert Siman, Yin-Guo Lin, Gauri Malthankar-Phatak, Yina Don. A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy. Journal of neuropathology and experimental neurology. vol 72. issue 11. 2013-12-17. PMID:24128676. |
the perforant pathway projection from the entorhinal cortex (ec) to the hippocampal dentate gyrus is critically important for long-term memory and develops tau and amyloid pathologies and progressive degeneration starting in the early stages of alzheimer disease (ad). |
2013-12-17 |
2023-08-12 |
mouse |
| Dong Liu, Michael Pitta, Haiyang Jiang, Jong-Hwan Lee, Guofeng Zhang, Xinzhi Chen, Elisa M Kawamoto, Mark P Mattso. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23273573. |
treatment of 3xtgad mice with nicotinamide for 8 months resulted in improved cognitive performance, and reduced aβ and hyperphosphorylated tau pathologies in hippocampus and cerebral cortex. |
2013-12-11 |
2023-08-12 |
mouse |
| Yoshihiro Kashiwaya, Christian Bergman, Jong-Hwan Lee, Ruiqian Wan, M Todd King, Mohamed R Mughal, Eitan Okun, Kieran Clarke, Mark P Mattson, Richard L Veec. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23276384. |
ket-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. |
2013-12-11 |
2023-08-12 |
mouse |
| S Flunkert, M Hierzer, T Löffler, R Rabl, J Neddens, S Duller, E L Schofield, M A Ward, M Posch, H Jungwirth, M Windisch, B Hutter-Paie. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neuro-degenerative diseases. vol 11. issue 4. 2013-11-13. PMID:22797329. |
histological analyses showed a progressive increase in human tau protein in the amygdala over age, while hippocampal tau levels remained constant from 2 months onwards. |
2013-11-13 |
2023-08-12 |
mouse |
| Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q Trojanowski, Virginia M-Y Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuch. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. vol 79. issue 6. 2013-11-13. PMID:24050400. |
a pyridinated pbb, [(11)c]pbb3, was next applied in a clinical pet study, and its robust signal in the ad hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [(11)c]pittsburgh compound-b ([(11)c]pib). |
2013-11-13 |
2023-08-12 |
mouse |
| Chu-Wan Lee, Yao-Hsiang Shih, Shih-Ying Wu, Tingting Yang, Chingju Lin, Yu-Min Ku. Hypoglycemia induces tau hyperphosphorylation. Current Alzheimer research. vol 10. issue 3. 2013-11-11. PMID:23036024. |
stz-icv treatment increased the levels of phosphorylated tau and activated gsk3β, but decreased the levels of activated akt in the hippocampus. |
2013-11-11 |
2023-08-12 |
rat |
| Lourdes Orejana, Lucía Barros-Miñones, Norberto Aguirre, Elena Puert. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Experimental gerontology. vol 48. issue 6. 2013-11-07. PMID:23501261. |
however, this same treatment of sildenafil, that had been shown to reverse the cognitive impairment and tau hyperphosphorylation in this animal model, also reversed the increased levels of activated jnk (p-jnk) found in the hippocampus of samp8 mice. |
2013-11-07 |
2023-08-12 |
mouse |
| Lourdes Orejana, Lucía Barros-Miñones, Norberto Aguirre, Elena Puert. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Experimental gerontology. vol 48. issue 6. 2013-11-07. PMID:23501261. |
when phosphorylated tau (at8 epitope) was analyzed a significant reduction was observed in the hippocampus of d-jnki-1 treated samp8 mice, providing a plausible explanation for the attenuation of cognitive decline shown by these animals. |
2013-11-07 |
2023-08-12 |
mouse |
| Nataliya G Kolosova, Anton O Vitovtov, Natalia A Muraleva, Andrey E Akulov, Natalia A Stefanova, Mikhail V Blagosklonn. Rapamycin suppresses brain aging in senescence-accelerated OXYS rats. Aging. vol 5. issue 6. 2013-11-07. PMID:23817674. |
rapamycin significantly decreased tau and inhibited its phosphorylation in the hippocampus of oxys and wistar rats. |
2013-11-07 |
2023-08-12 |
mouse |
| Jon B Toledo, Steven E Arnold, Kevin Raible, Johannes Brettschneider, Sharon X Xie, Murray Grossman, Sarah E Monsell, Walter A Kukull, John Q Trojanowsk. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain : a journal of neurology. vol 136. issue Pt 9. 2013-11-07. PMID:23842566. |
presence of cerebrovascular disease, vascular pathology and vascular risk factors was studied in 5715 cases of the national alzheimer's coordinating centre database with a single neurodegenerative disease diagnosis (alzheimer's disease, frontotemporal lobar degeneration due to tau, and tar dna-binding protein 43 immunoreactive deposits, α-synucleinopathies, hippocampal sclerosis and prion disease) based on a neuropathological examination with or without cerebrovascular disease, defined neuropathologically. |
2013-11-07 |
2023-08-12 |
human |
| Sónia C Correia, Renato X Santos, Maria S Santos, Gemma Casadesus, Joseph C Lamanna, George Perry, Mark A Smith, Paula I Moreir. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Current Alzheimer research. vol 10. issue 4. 2013-11-05. PMID:23061885. |
icvstz administration also resulted in a significant increase in hippocampal amyloid beta peptide 1-42 (aβ(1-42)) levels as well as in cortical and hippocampal hyperphosphorylated tau protein levels. |
2013-11-05 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
mtor and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and alzheimer's disease. |
2013-11-04 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
mtor activity and tau protein hyperphosphorylation in the hippocampus were analyzed by immunohistochemical staining and rt-pcr. |
2013-11-04 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
t2dm may excessively activate mtor in the hippocampal tissue by impairing insulin signaling, thereby increasing the extent of tau hyperphosphorylation and promoting the occurrence of ad. |
2013-11-04 |
2023-08-12 |
rat |