| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--the pivotal role of brain M1 receptors. Neuro-degenerative diseases vol 5 issue 3-4 2008 18322400 |
in triple transgenic ad mice, af267b reduced cognitive deficits and decreased abeta(42) and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr activation of protein kinase c and a disintegrin and metalloproteinase domain 17 (adam17 or tace) and decreased beta-site amyloid precursor protein-cleaving enzyme 1 and glycogen synthase kinase 3beta, respectively. |
2008-05-15 |
2023-01-24 |
mouse |
| Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, Fred Van Leuve. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American journal of pathology vol 172 issue 3 2008 18258852 |
extensive and remarkable parallels were observed between these strains including 1) aggravation of tauopathy with highly fibrillar tangles in the hippocampus and cortex; 2) prolonged survival correlated to alleviated brainstem tauopathy; 3) development of severe cognitive and behavioral defects in young adults before the onset of amyloid deposition or tauopathy; and 4) presence of pathological phospho-epitopes of tau, including the characteristic gsk-3beta motif at s396/s404. |
2008-05-09 |
2023-01-24 |
mouse |
| Lei Zhong, Jie Tan, Shi Ouyang, Jiang-ping X. [Effects of Saponin B from Anemarrhena asphodeloides Bunge on tau hyperphosphorylation induced by beta-amyloid peptide (25-35) in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University vol 26 issue 8 2008 16939894 |
to investigate the changes in the expressions of p53, dkk (the inhibitor of wnt pathway) and phosphorylated tau in rat bilateral hippocampus after beta-amyloid peptide (beta-ap) (25-35) injection, and observe the effect of saponin b from anemarrhena asphodeloides bunge (saab) in this model. |
2008-05-05 |
2023-01-24 |
rat |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine (\"Ecstasy\"). The Journal of neuroscience : the official journal of the Society for Neuroscience vol 28 issue 12 2008 18354027 |
enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("ecstasy"). |
2008-04-25 |
2023-01-24 |
mouse |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine (\"Ecstasy\"). The Journal of neuroscience : the official journal of the Society for Neuroscience vol 28 issue 12 2008 18354027 |
an acute or 6 d treatment with mdma increased tau protein phosphorylation in the hippocampus, revealed by both anti-phospho(ser(404))-tau and paired helical filament-1 antibodies. |
2008-04-25 |
2023-01-24 |
mouse |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine (\"Ecstasy\"). The Journal of neuroscience : the official journal of the Society for Neuroscience vol 28 issue 12 2008 18354027 |
we conclude that tau hyperphosphorylation in the hippocampus may contribute to the impairment of learning and memory associated with mdma abuse. |
2008-04-25 |
2023-01-24 |
mouse |
| Ina Hinners, Anika Hill, Ulrike Otto, Anke Michalsky, Till G A Mack, Frank Striggo. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Molecular and cellular neurosciences vol 37 issue 3 2008 18201898 |
tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. |
2008-04-10 |
2023-01-24 |
human |
| Shinji Higashi, Eizo Iseki, Ryoko Yamamoto, Michiko Minegishi, Hiroaki Hino, Koshiro Fujisawa, Takashi Togo, Omi Katsuse, Hirotake Uchikado, Yoshiko Furukawa, Kenji Kosaka, Heii Ara. Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain research vol 1184 issue 2008 17963732 |
the amygdala and hippocampus that were vulnerable to tau or alpha-synuclein pathology demonstrated more severe tdp-43 pathology in ad and dlb cases than in ftld-u cases. |
2008-04-08 |
2023-01-24 |
Not clear |
| Matthew Schrag, Sunita Sharma, Holly Brown-Borg, Othman Ghrib. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus vol 18 issue 3 2008 18000817 |
hippocampus of ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. |
2008-03-27 |
2023-01-24 |
mouse |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Current Alzheimer research vol 4 issue 5 2008 18220527 |
in 3x transgenic-ad mice that recapitulate the major pathologies and cognitive deficits of ad, chronic af267b treatment rescued cognitive deficits and decreased abeta42 and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr-activation of adam17/tace and decreased bace1 steady state levels and inhibition of gsk3beta, extending findings from above. |
2008-03-21 |
2023-01-24 |
mouse |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology vol 34 issue 1 2008 17961140 |
in this study we investigate the influence of hippocampal tau pathology on secretagogin expression in more details. |
2008-03-18 |
2023-01-24 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology vol 34 issue 1 2008 17961140 |
because there are no differences in the amount of hippocampal secretagogin expression between ad cases and controls (as we have shown previously), the lack of an association between the amount of secretagogin expression and tau burden together with the low frequency of colocalization of tau and secretagogin in the human hippocampus, suggest that secretagogin-expressing neurones are largely resistant to neurodegeneration in ad. |
2008-03-18 |
2023-01-24 |
human |
| Salvatore Spina, Martin R Farlow, Frederick W Unverzagt, David A Kareken, Jill R Murrell, Graham Fraser, Francine Epperson, R Anthony Crowther, Maria G Spillantini, Michel Goedert, Bernardino Ghett. The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family. Brain : a journal of neurology vol 131 issue Pt 1 2008 18065436 |
neuropathologically, progressive nerve cell loss, gliosis and coexistent neuronal and/or glial deposits consisting mostly of 4-repeat tau were present in frontal, cingulate, temporal and insular cortices, white matter, hippocampus, parahippocampus, basal ganglia, selected brainstem nuclei and spinal cord. |
2008-03-06 |
2023-01-24 |
Not clear |
| Tristan Bolmont, Florence Clavaguera, Melanie Meyer-Luehmann, Martin C Herzig, Rebecca Radde, Matthias Staufenbiel, Jada Lewis, Mike Hutton, Markus Tolnay, Mathias Jucke. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American journal of pathology vol 171 issue 6 2008 18055549 |
six months after the infusion, tau pathology was induced in the injected hippocampus but also in brain regions well beyond the injection sites such as the entorhinal cortex and amygdala, areas with neuronal projection to the injection site. |
2008-02-08 |
2023-01-24 |
mouse |
| Osamu Yokota, Kuniaki Tsuchiya, Yoshimasa Noguchi, Hisamasa Akabane, Hideki Ishizu, Yukinobu Saito, Haruhiko Akiyam. Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. Neuropathology : official journal of the Japanese Society of Neuropathology vol 27 issue 6 2008 18021374 |
in the hippocampus, selective tau accumulation with minor neurofibrillary changes was observed in ca2 neurons. |
2008-01-16 |
2023-01-24 |
Not clear |
| H Hampel, S J Teipel, K B\\xc3\\xbcrge. [Neurobiological early diagnosis of Alzheimer's disease]. Der Nervenarzt vol 78 issue 11 2008 17611728 |
to date the most promising core candidate markers are total and hyperphosphorylated tau protein and amyloid beta peptides in the csf, as well as hippocampus and whole brain volumetry using mri. |
2008-01-15 |
2023-01-24 |
human |
| Joongkyu Park, Eun Jin Yang, Joo Heon Yoon, Kwang Chul Chun. Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Molecular and cellular neurosciences vol 36 issue 2 2008 17720532 |
our results show that dyrk1a interacts with and directly phosphorylates tau and amyloid precursor protein in immortalized hippocampal progenitor h19-7 cells. |
2008-01-09 |
2023-01-24 |
human |
| Adam R Cole, Wendy Noble, Lidy van Aalten, Florian Plattner, Rena Meimaridou, Dale Hogan, Margaret Taylor, John LaFrancois, Frank Gunn-Moore, Alex Verkhratsky, Salvatore Oddo, Frank LaFerla, K Peter Giese, Kelly T Dineley, Karen Duff, Jill C Richardson, Shi Du Yan, Diane P Hanger, Stuart M Allan, Calum Sutherlan. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of neurochemistry vol 103 issue 3 2007 17683481 |
similarly, crmp2 phosphorylation is normal in hippocampus and cortex of tau(p301l) mice that develop tangles but not plaques. |
2007-12-21 |
2023-01-24 |
mouse |
| Ranu Pal, Derek B Oien, Fatma Y Ersen, Jackob Moskovit. Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse. Experimental brain research vol 180 issue 4 2007 17333008 |
additionally, a loss of astrocytes integrity, elevated levels of beta-amyloid deposition, and tau phosphorylation were dominant in various regions of the msra ( -/- ) hippocampus but not in the wild-type. |
2007-11-26 |
2023-01-24 |
mouse |
| Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casament. Abnormal processing of tau in the brain of aged TgCRND8 mice. Neurobiology of disease vol 27 issue 3 2007 17656099 |
in the neocortex and hippocampus of aged tgcrnd8 mice, tau is hyperphosphorylated at different sites recognized by phf-1, at100, at8 and cp13 antibodies. |
2007-10-31 |
2023-01-24 |
mouse |