| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James L Searcy, Jeremiah T Phelps, Tristano Pancani, Inga Kadish, Jelena Popovic, Katie L Anderson, Tina L Beckett, Michael P Murphy, Kuey-Chu Chen, Eric M Blalock, Philip W Landfield, Nada M Porter, Olivier Thibaul. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22495349. |
after four months, pio-treated animals showed multiple beneficial effects, including improved learning on the active avoidance task, reduced serum cholesterol, decreased hippocampal amyloid-β and tau deposits, and enhanced short- and long-term plasticity. |
2013-05-15 |
2023-08-12 |
mouse |
| Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. |
to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). |
2013-05-14 |
2023-08-12 |
human |
| Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Lange. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS genetics. vol 8. issue 11. 2013-05-13. PMID:23144624. |
we observe early onset tau hyperphosphorylation and filament formation in the hippocampus, demonstrating a direct link between mitochondrial defects and tau pathology. |
2013-05-13 |
2023-08-12 |
mouse |
| Magdalena Więdłocha, Bartłomiej Stańczykiewicz, Marta Jakubik, Joanna Rymaszewsk. [Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer's disease]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-05-02. PMID:22922141. |
their brain tissue, depending on the mutation, is characterized by histopathological changes, such as the presence of amyloid plaques, tau protein deposits and dystrophic neurites, gliosis, hippocampal atrophy and amyloid accumulation in vessels. |
2013-05-02 |
2023-08-12 |
mouse |
| Jing L Guo, Virginia M Y Le. Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau. FEBS letters. vol 587. issue 6. 2013-04-30. PMID:23395797. |
here we show that synthetic tau fibrils made from recombinant protein not only time-dependently recruit normal tau into neurofibrillary tangle-like insoluble aggregates in primary hippocampal neurons over-expressing human tau, but also induce neuritic tau pathology in non-transgenic neurons. |
2013-04-30 |
2023-08-12 |
human |
| Qiu-Lan Ma, Xiaohong Zuo, Fusheng Yang, Oliver J Ubeda, Dana J Gant, Mher Alaverdyan, Edmond Teng, Shuxin Hu, Ping-Ping Chen, Panchanan Maiti, Bruce Teter, Greg M Cole, Sally A Frautsch. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. The Journal of biological chemistry. vol 288. issue 6. 2013-04-19. PMID:23264626. |
transgene-dependent elevations in soluble and insoluble phospho-tau monomer and soluble tau dimers accompanied deficits in behavior, hippocampal excitatory synaptic markers, and molecular chaperones (heat shock proteins (hsps)) involved in tau degradation and microtubule stability. |
2013-04-19 |
2023-08-12 |
mouse |
| Michiyo Iba, Jing L Guo, Jennifer D McBride, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325240. |
interestingly, injection of tau pffs into either hippocampus or striatum together with overlaying cortex gave rise to distinct pattern of spreading. |
2013-04-01 |
2023-08-12 |
mouse |
| Jerrah K Holth, Valerie C Bomben, J Graham Reed, Taeko Inoue, Linda Younkin, Steven G Younkin, Robia G Pautler, Juan Botas, Jeffrey L Noebel. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345237. |
tau reduction decreased kcna1(-/-) video-eeg recorded seizure frequency and duration as well as normalized kcna1(-/-) hippocampal network hyperexcitability in vitro. |
2013-03-20 |
2023-08-12 |
mouse |
| Jerrah K Holth, Valerie C Bomben, J Graham Reed, Taeko Inoue, Linda Younkin, Steven G Younkin, Robia G Pautler, Juan Botas, Jeffrey L Noebel. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345237. |
additionally, tau reduction increased kcna1(-/-) survival and prevented megencephaly and hippocampal hypertrophy, as determined by mri. |
2013-03-20 |
2023-08-12 |
mouse |
| Julie A Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Muck. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PloS one. vol 7. issue 9. 2013-02-28. PMID:23029293. |
human and pathological tau was also detected within hippocampal neurons of this mouse model. |
2013-02-28 |
2023-08-12 |
mouse |
| Aliesha González-Arenas, Ana Gabriela Piña-Medina, Oscar González-Flores, Porfirio Gómora-Arrati, Graciela Elena Carrillo-Martínez, Marco Antonio Balandrán-Ruíz, Ignacio Camacho-Arroy. Expression pattern of Tau in the rat brain during pregnancy and the beginning of lactation. Brain research bulletin. vol 89. issue 3-4. 2013-02-27. PMID:22884690. |
in hippocampus tau content decreased on day 14 until day 21 compared with day 2 of gestation, however, in lactation day 2 the content of tau increased meanwhile phosphotau content progressively increased throughout pregnancy. |
2013-02-27 |
2023-08-12 |
rat |
| Balu Chakravarthy, Chantal Gaudet, Michel Ménard, Leslie Brown, Trevor Atkinson, Frank M Laferla, Shingo Ito, Ubaldo Armato, Ilaria Dal Prà, James Whitfiel. Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22995307. |
reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xad-transgenic mice producing human aβ(1-42) and tau. |
2013-02-27 |
2023-08-12 |
mouse |
| Masahiro Nakamori, Tetsuya Takahashi, Yuu Yamazaki, Takashi Kurashige, Takemori Yamawaki, Masayasu Matsumot. Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration. Neuroreport. vol 23. issue 15. 2013-02-12. PMID:22968343. |
in addition, cyclin-dependent kinase 5 (cdk5), which phosphorylates tau, has been shown to be abundantly expressed in neurofibrillary tangles in the hippocampus. |
2013-02-12 |
2023-08-12 |
Not clear |
| Carolina García-Barroso, Ana Ricobaraza, María Pascual-Lucas, Nora Unceta, Alberto J Rico, Maria Aranzazu Goicolea, Joan Sallés, José Luis Lanciego, Julen Oyarzabal, Rafael Franco, Mar Cuadrado-Tejedor, Ana García-Ost. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology. vol 64. 2013-02-11. PMID:22776546. |
biochemical analysis revealed that neither sildenafil nor tadalafil altered the amyloid burden, although both compounds reduced tau phosphorylation in the mouse hippocampus. |
2013-02-11 |
2023-08-12 |
mouse |
| Marta Dobarro, Lourdes Orejana, Norberto Aguirre, María Javier Ramíre. Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model. Neuropharmacology. vol 64. 2013-02-11. PMID:22824191. |
tau hyperphosphorylation (phf-1 epitope) shown by samp8 mice at this age was also decreased in the hippocampus of propranolol-treated mice, an effect probably related to a decrease in jnk1 expression. |
2013-02-11 |
2023-08-12 |
mouse |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
considering that insulin mitigates hippocampal synapse vulnerability to amyloid beta and inhibits the phosphorylation of tau, pharmacological strategies bolstering brain insulin signaling, such as intranasal insulin, could have significant therapeutic potential to deter ad pathogenesis. |
2013-01-31 |
2023-08-12 |
Not clear |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
chronic noise exposure causes persistence of tau hyperphosphorylation and formation of nft tau in the rat hippocampus and prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
the aim of the current study was to explore the effects of cne [100 db sound pressure level (spl) white noise, 4 h/d×14 d] on tau phosphorylation in the rat hippocampus and the prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
the levels of radioimmunoprecipitation assay (ripa)-soluble and ripa-insoluble phosphorylated tau at ser202, ser396, ser404, and ser422 in the hippocampus and the prefrontal cortex were measured at different time points (days 0, 3, 7, and 14) after the end of the last noise exposure. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
exposure to white noise for 14 consecutive days significantly increased the levels of tau phosphorylation at ser202, ser396, ser404, and ser422, the sites typically phosphorylated in ad brains, in the hippocampus and the prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |