| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howel. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355340. |
tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the tau phosphorylation phenotype is a secondary effect of the morbidity of these mutants. |
2012-06-18 |
2023-08-12 |
mouse |
| Sarah M Rothman, Nathan Herdener, Simonetta Camandola, Sarah J Texel, Mohamed R Mughal, Wei-Na Cong, Bronwen Martin, Mark P Mattso. 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21855175. |
a triple-transgenic mouse model of ad (3xtgad mice) and nontransgenic control mice were used to test for an affect of chronic mild social stress on blood glucose, plasma glucocorticoids, plasma insulin, anxiety, and hippocampal amyloid β-particle (aβ), phosphorylated tau (ptau), and brain-derived neurotrophic factor (bdnf) levels. |
2012-06-15 |
2023-08-12 |
mouse |
| Rodolfo Pinto-Almazán, Claudia C Calzada-Mendoza, María G Campos-Lara, Christian Guerra-Araiz. Effect of chronic administration of estradiol, progesterone, and tibolone on the expression and phosphorylation of glycogen synthase kinase-3β and the microtubule-associated protein tau in the hippocampus and cerebellum of female rat. Journal of neuroscience research. vol 90. issue 4. 2012-06-12. PMID:22183707. |
effect of chronic administration of estradiol, progesterone, and tibolone on the expression and phosphorylation of glycogen synthase kinase-3β and the microtubule-associated protein tau in the hippocampus and cerebellum of female rat. |
2012-06-12 |
2023-08-12 |
rat |
| Rodolfo Pinto-Almazán, Claudia C Calzada-Mendoza, María G Campos-Lara, Christian Guerra-Araiz. Effect of chronic administration of estradiol, progesterone, and tibolone on the expression and phosphorylation of glycogen synthase kinase-3β and the microtubule-associated protein tau in the hippocampus and cerebellum of female rat. Journal of neuroscience research. vol 90. issue 4. 2012-06-12. PMID:22183707. |
we studied the effect of chronic administration of estradiol (e2), progesterone (p4), and tibolone (tib) on the expression and phosphorylation of microtubule-associated protein tau and glycogen synthase kinase-3β (gsk3β) in the hippocampus and cerebellum of ovariectomized rats. |
2012-06-12 |
2023-08-12 |
rat |
| Rodolfo Pinto-Almazán, Claudia C Calzada-Mendoza, María G Campos-Lara, Christian Guerra-Araiz. Effect of chronic administration of estradiol, progesterone, and tibolone on the expression and phosphorylation of glycogen synthase kinase-3β and the microtubule-associated protein tau in the hippocampus and cerebellum of female rat. Journal of neuroscience research. vol 90. issue 4. 2012-06-12. PMID:22183707. |
we observed that, in the hippocampus, administration of e2, p4, or tib significantly decreased the protein content of hyperphosphorylated tau and increased the tau dephosphorylated form, whereas only treatment with tib increased the content of the phosphorylated form of gsk3β. |
2012-06-12 |
2023-08-12 |
rat |
| Rodolfo Pinto-Almazán, Claudia C Calzada-Mendoza, María G Campos-Lara, Christian Guerra-Araiz. Effect of chronic administration of estradiol, progesterone, and tibolone on the expression and phosphorylation of glycogen synthase kinase-3β and the microtubule-associated protein tau in the hippocampus and cerebellum of female rat. Journal of neuroscience research. vol 90. issue 4. 2012-06-12. PMID:22183707. |
these results indicate that chronic administration of gonadal hormones and tibolone modulates tau and gsk3β phosphorylation in hippocampus and cerebellum of the rat and may exert a neuroprotective effect in these tissues. |
2012-06-12 |
2023-08-12 |
rat |
| Eun Ji Gong, Hee Ra Park, Mi Eun Kim, Shunfu Piao, Eunjin Lee, Dong-Gyu Jo, Hae Young Chung, Nam-Chul Ha, Mark P Mattson, Jaewon Le. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782947. |
furthermore, treatment of 3xtg-ad mice with morin resulted in reductions in tau hyperphosphorylation and paired helical filament-like immunoreactivity in hippocampal neurons. |
2012-06-11 |
2023-08-12 |
mouse |
| Evelin L Schaeffer, Vanessa J De-Paula, Emanuelle R da Silva, Barbara de A Novaes, Heni D Skaf, Orestes V Forlenza, Wagner F Gatta. Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 9. 2012-06-01. PMID:21387172. |
the aim of this study was to conduct a preliminary investigation into the effects of in vivo infusion of mafp into rat brain on pla(2) activity and total tau levels in the postmortem frontal cortex and dorsal hippocampus. |
2012-06-01 |
2023-08-12 |
human |
| Daowei Lin, Lin Cao, Zhi Wang, Jiejie Li, Jacqueline M Washington, Zhiyi Zu. Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats. Behavioural brain research. vol 228. issue 2. 2012-05-23. PMID:22192381. |
isoflurane and lidocaine did not affect the amount of β-amyloid peptide, total tau and phospho-tau in the cerebral cortex as well as interleukin-1β and tumor necrosis factor-α in the hippocampus at 29 days after isoflurane exposure. |
2012-05-23 |
2023-08-12 |
rat |
| Thomas van Groen, Inga Kadish, Natalija Popović, Miroljub Popović, María Caballero-Bleda, Beatriz Baño-Otálora, Pablo Vivanco, María Ángeles Rol, Juan Antonio Madri. Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology. Neurobiology of aging. vol 32. issue 9. 2012-05-17. PMID:19910078. |
significant amounts of aβ and tau deposits are present in the hippocampal formation of 6-year-old o. degus, primarily in the white matter, but these hippocampal aβ and tau deposits are not present in younger ones. |
2012-05-17 |
2023-08-12 |
Not clear |
| Thomas van Groen, Inga Kadish, Natalija Popović, Miroljub Popović, María Caballero-Bleda, Beatriz Baño-Otálora, Pablo Vivanco, María Ángeles Rol, Juan Antonio Madri. Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology. Neurobiology of aging. vol 32. issue 9. 2012-05-17. PMID:19910078. |
the tau deposits in the hippocampal formation coincide with a significant decrease in staining for myelin in the same areas, indicating hippocampal disconnection and, likely, dysfunction. |
2012-05-17 |
2023-08-12 |
Not clear |
| Heinz-Georg Jahnke, Annett Braesigk, Till G A Mack, Sarah Pönick, Frank Striggow, Andrea A Robitzk. Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. Biosensors & bioelectronics. vol 32. issue 1. 2012-05-14. PMID:22221799. |
we induced tau hyperphosphorylation in organotypic hippocampal slice cultures (ohsc) and applied marker-independent real-time electrical impedance spectroscopy (eis) for cellular real-time pathology monitoring. |
2012-05-14 |
2023-08-12 |
Not clear |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. |
2012-05-11 |
2023-08-12 |
rat |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
effects of noise on the glutamate (glu)-n-methyl-d-aspartic acid receptor (nmdar) signaling system and hippocampal tau phosphorylation were investigated by high performance liquid chromatography, western blotting, and immunohistochemistry. |
2012-05-11 |
2023-08-12 |
rat |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
impulse noise stress also caused a significant increase in nmdar 2b subunit (nr2b) expression and a two-phase increase in tau phosphorylation in hippocampus. |
2012-05-11 |
2023-08-12 |
rat |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
immunohistochemistry confirmed tau hyperphosphorylation in hippocampus that was most prominent in the dentate gyrus (dg) and ca1 region. |
2012-05-11 |
2023-08-12 |
rat |
| Bo Cui, Mingquan Wu, Xiaojun She, Hongtao Li. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain research. vol 1427. 2012-05-11. PMID:22055774. |
these findings demonstrate that impulse noise stress impairs early spatial memory, possibly by disrupting glu-nmdar signaling and triggering aberrant tau hyperphosphorylation in hippocampus. |
2012-05-11 |
2023-08-12 |
rat |
| Xifei Yang, Ying Yang, Jianjun Liu, Geng Li, Edward Yan. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochemical research. vol 37. issue 1. 2012-05-09. PMID:21842270. |
the data showed that the phosphorylation of tau at ser396, ser404, thr231 and tau-1 (ser198/199/202) epitopes was significantly increased in hippocampus of the aged (twenty-one and a half-month-old) transgenic mice expressing ps-1 (l235p) compared to that of the age-matched wild-type littermates (wts). |
2012-05-09 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
after 9 months of exercise, mice were evaluated for memory performance and examined for hippocampal tau pathology, cholinergic defects, inflammation and genes related to cholesterol metabolism. |
2012-05-07 |
2023-08-12 |
mouse |
| Karim Belarbi, Sylvie Burnouf, Francisco-Jose Fernandez-Gomez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laetitia Troquier, Antoine Leboucher, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Hélène Obriot, Ingrid Brion, Bérangère Barbot, Marie-Christine Galas, Bart Staels, Sandrine Humez, Nicolas Sergeant, Susanna Schraen-Maschke, Anne Muhr-Tailleux, Malika Hamdane, Luc Buée, David Blu. Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21569847. |
this was accompanied by a decrease in hippocampal tau pathology and a prevention of the loss of expression of choline acetyltransferase within the medial septum. |
2012-05-07 |
2023-08-12 |
mouse |