| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isidro Ferrer, Ana Gómez, Margarita Carmona, Gema Huesa, Silvia Porta, Miquel Riera-Codina, Marta Biagioli, Stefano Gustincich, Ester As. Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. Journal of Alzheimer's disease : JAD. vol 23. issue 3. 2011-12-20. PMID:21157025. |
double labeling immunofluorescence and confocal microscopy revealed reduced hemoglobin α-chain and β-chain in practically all neurons with small amounts of granular or punctuate hyperphosphorylated tau deposits and in neurons with tangles in the hippocampus and frontal cortex in ad and in the hippocampus in agd; in ballooned neurons containing αb-crystallin in the amygdala in ad and agd; and in about 80% of neurons with punctuate α-synuclein deposits and in neurons with lewy bodies in the substantia nigra pars compacta and in vulnerable neurons of the medulla oblongata in pd and dlb; and in neurons with lewy bodies in the frontal cortex in dlb. |
2011-12-20 |
2023-08-12 |
human |
| Maria Thom, Joan Y W Liu, Pam Thompson, Rahul Phadke, Marta Narkiewicz, Lillian Martinian, Derek Marsdon, Matthias Koepp, Luis Caboclo, Claudia B Catarino, Sanjay M Sisodiy. Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study. Brain : a journal of neurology. vol 134. issue Pt 10. 2011-12-15. PMID:21903728. |
hippocampal sclerosis, identified in 40% (bilateral in 48%), was not associated with higher braak stages, but asymmetrical patterns of tau protein accumulation within the sclerotic hippocampus were noted. |
2011-12-15 |
2023-08-12 |
Not clear |
| R Scott Bitner, Stella Markosyan, Arthur L Nikkel, Jorge D Brion. In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:21044639. |
in addition, abt-239 infusion reversed tau hyperphosphorylation in the spinal cord and hippocampus of tapp (tau × app) ad-transgenic mice. |
2011-11-22 |
2023-08-12 |
mouse |
| Kaoru Yamada, John R Cirrito, Floy R Stewart, Hong Jiang, Mary Beth Finn, Brandon B Holmes, Lester I Binder, Eva-Maria Mandelkow, Marc I Diamond, Virginia M-Y Lee, David M Holtzma. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 37. 2011-11-22. PMID:21917794. |
to address these issues, we developed a microdialysis technique to analyze monomeric isf tau levels within the hippocampus of awake, freely moving mice. |
2011-11-22 |
2023-08-12 |
mouse |
| Kaoru Yamada, John R Cirrito, Floy R Stewart, Hong Jiang, Mary Beth Finn, Brandon B Holmes, Lester I Binder, Eva-Maria Mandelkow, Marc I Diamond, Virginia M-Y Lee, David M Holtzma. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 37. 2011-11-22. PMID:21917794. |
tau fibrils injected into the hippocampus decreased isf tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. |
2011-11-22 |
2023-08-12 |
mouse |
| b' Gemma Manich, Clara Mercader, Jaume del Valle, Joaquim Duran-Vilaregut, Antoni Camins, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Jordi Vilaplana, Carme Pelegr\\xc3\\xa. Characterization of amyloid-\\xce\\xb2 granules in the hippocampus of SAMP8 mice. Journal of Alzheimer\'s disease : JAD. vol 25. issue 3. 2011-11-15. PMID:21460438.' |
here we performed several studies to examine whether the aβ granules in the hippocampus of samp8 mice contain other proteins characteristic of neuropathological aggregates, such as tau, map2, and α-synuclein. |
2011-11-15 |
2023-08-12 |
mouse |
| S Galluzzi, C Geroldi, R Ghidoni, B Paghera, G Amicucci, M Bonetti, O Zanetti, M Cotelli, M Gennarelli, G B Frison. The new Alzheimer's criteria in a naturalistic series of patients with mild cognitive impairment. Journal of neurology. vol 257. issue 12. 2011-11-10. PMID:20632026. |
medial temporal (mt) atrophy on mri was defined as hippocampal volume below the fifth percentile of the distribution in healthy elders, abnormal csf was based on sjogren's cutoffs for abeta42 and tau, and temporoparietal hypometabolism on 18f-fdg pet based on herholz's t sum score. |
2011-11-10 |
2023-08-12 |
Not clear |
| Gabor G Kovacs, Kinga Molnár, Lajos László, Thomas Ströbel, Gergö Botond, Selma Hönigschnabl, Angelika Reiner-Concin, Miklós Palkovits, Peter Fischer, Herbert Budk. A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta neuropathologica. vol 122. issue 2. 2011-11-02. PMID:21437732. |
in addition to neurofibrillary tangles and diffuse neuronal cytoplasmic tau immunoreactivity, the neuropathology was characterized by peculiar cytopathologies (diffuse granular immunopositivity of astrocytic processes and patchy accumulation of thin threads) in a distinctive distribution (frontal and temporal cortices, hippocampus, amygdala, basal ganglia, locus coeruleus, and substantia nigra). |
2011-11-02 |
2023-08-12 |
Not clear |
| C-H Yu, G-S Song, J-Y Yhee, J-H Kim, K-S Im, W-G Nho, J-H Lee, J-H Su. Histopathological and immunohistochemical comparison of the brain of human patients with Alzheimer's disease and the brain of aged dogs with cognitive dysfunction. Journal of comparative pathology. vol 145. issue 1. 2011-10-14. PMID:21256508. |
changes in the brain of aged dogs with cognitive dysfunction were compared with those in the brain of patients with ad of braak stage v. immunohistochemically, aβ deposition, phosphorylated tau ser396 (p-tau ser396) and ubiquitin were observed in the parietal cortex and hippocampus of aged dogs with cognitive dysfunction. |
2011-10-14 |
2023-08-12 |
human |
| J L Whitwell, S D Weigand, J L Gunter, B F Boeve, R Rademakers, M Baker, D S Knopman, Z K Wszolek, R C Petersen, C R Jack, K A Joseph. Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN. Neurology. vol 77. issue 4. 2011-09-27. PMID:21753165. |
to use multiple serial mri to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (ftd) with progranulin (grn) or microtubule-associated protein tau (mapt) gene mutations. |
2011-09-27 |
2023-08-12 |
human |
| Allal Boutajangout, Johanna Ingadottir, Peter Davies, Einar M Sigurdsso. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21644996. |
the treated mice performed better than controls on the traverse beam task (p < 0.03), and had 58% less tau pathology in the dentate gyrus of the hippocampus (p = 0.02). |
2011-09-16 |
2023-08-12 |
mouse |
| G Amadoro, V Corsetti, M T Ciotti, F Florenzano, S Capsoni, G Amato, P Calissan. Endogenous Aβ causes cell death via early tau hyperphosphorylation. Neurobiology of aging. vol 32. issue 6. 2011-09-13. PMID:19628305. |
we report that an early, transient and site-specific ad-like tau hyperphosphorylation at ser262 and thr231 epitopes is temporally and causally related with an activation of the endogenous amyloidogenic pathway that we previously reported in hippocampal neurons undergoing cell death upon ngf withdrawal [matrone, c., ciotti, m.t., mercanti, d., marolda, r., calissano, p., 2008b. |
2011-09-13 |
2023-08-12 |
Not clear |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
reduced secretagogin expression in the hippocampus of p301l tau transgenic mice. |
2011-09-08 |
2023-08-12 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
neuropathological features in alzheimer's disease (ad) include the presence of hyperphosphorylated forms of the microtubule-associated tau protein (tau) in hippocampal neurones. |
2011-09-08 |
2023-08-12 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
here, we investigated secretagogin expression in wild type (wt) mice as well as in hemizygous and homozygous p301l tau transgenic (tg) mice, which show pronounced and widespread tau pathology in hippocampal neurones. |
2011-09-08 |
2023-08-12 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
in wt mice hippocampal secretagogin-immunoreactive neurones were invariably detected, while immunoreactivity was much lower (p < 0.001) in tau tg mice. |
2011-09-08 |
2023-08-12 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
of note, hippocampal secretagogin immunoreactivity was absent in 62.5% of homozygous tau tg mice. |
2011-09-08 |
2023-08-12 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, Jürgen Götz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 5. 2011-09-08. PMID:21442354. |
our results suggest that increased levels of tau negatively influence secretagogin expression in the hippocampus of tau tg mice. |
2011-09-08 |
2023-08-12 |
mouse |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology. vol 37. issue 10. 2011-09-02. PMID:20659131. |
we used a splenectomized rat model with postoperative spatial learning and memory deficits to investigate the role of tau hyperphosphorylation and glycogen synthase kinase-3β (gsk-3β) within the hippocampus. |
2011-09-02 |
2023-08-12 |
rat |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology. vol 37. issue 10. 2011-09-02. PMID:20659131. |
we measured site-specific phosphorylation of hippocampal tau (thr-205 and ser-396), gsk-3β activity and expression of interleukin-1β (il-1β), tumour necrosis factor-α (tnf-α) mrna and protein as markers of inflammation. |
2011-09-02 |
2023-08-12 |
rat |