| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Liu, Michael Pitta, Jong-Hwan Lee, Balmiki Ray, Debomoy K Lahiri, Katsutoshi Furukawa, Mohamed Mughal, Haiyang Jiang, Julissa Villarreal, Roy G Cutler, Nigel H Greig, Mark P Mattso. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847430. |
3xtgad mice treated with diazoxide for 8 months exhibited improved performance in a learning and memory test, reduced levels of anxiety, decreased accumulation of aβ oligomers and hyperphosphorylated tau in the cortex and hippocampus, and increased cerebral blood flow. |
2011-03-09 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. |
essential role of tau phosphorylation in adult hippocampal neurogenesis. |
2011-03-07 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. |
an increased hippocampal neurogenesis has been observed in alzheimer disease (ad), the most common neurodegenerative disorder characterized with accumulation of β-amyloid (aβ) and hyperphosphorylated tau (p-tau). |
2011-03-07 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. |
a correlative increase of immature neuron markers and tau phosphorylation was induced in rat hippocampal dg by upregulating glycogen synthase kinase-3 (gsk-3), a crucial tau kinase, and the increased neurogenesis was due to an enhanced proliferation but not survival or differentiation of the newborn neurons. |
2011-03-07 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. |
the hippocampal neurogenesis was severely impaired in tau knockout mice and activation of gsk-3 in these mice did not rescue the deficits. |
2011-03-07 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. |
these results reveal an essential role of tau phosphorylation in adult hippocampal neurogenesis. |
2011-03-07 |
2023-08-12 |
mouse |
| Alexandra M Nicholson, D Nicole Riherd Methner, Adriana Ferreir. Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21047784. |
in this study, we assessed the molecular mechanisms by which cholesterol modulated aβ-induced tau cleavage in cultured hippocampal neurons. |
2011-03-02 |
2023-08-12 |
Not clear |
| Odete A B da Cruz e Silva, Ana Gabriela Henriques, Sara Catarina Timóteo Santos Domingues, Edgar F da Cruz e Silv. Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942790. |
individuals with alzheimer's disease (ad) exhibit extracellular senile plaques (sps) of aggregated a beta and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein (nfts), and also an extensive loss in basal forebrain cholinergic neurons that innervate the hippocampus and neocortex. |
2011-02-28 |
2023-08-12 |
mouse |
| Erik D Roberson, Brian Halabisky, Jong W Yoo, Jinghua Yao, Jeannie Chin, Fengrong Yan, Tiffany Wu, Patricia Hamto, Nino Devidze, Gui-Qiu Yu, Jorge J Palop, Jeffrey L Noebels, Lennart Muck. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 2. 2011-02-22. PMID:21228179. |
to better understand these protective effects, we recorded whole-cell currents in acute hippocampal slices from happ mice with and without tau. |
2011-02-22 |
2023-08-12 |
mouse |
| Azza Baraka, Samar ElGhotn. Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats. European journal of pharmacology. vol 641. issue 2-3. 2011-01-31. PMID:20639139. |
i.c.v.-abeta also resulted in significant increase in hippocampal hyperphosphorylated tau protein as well as galanin. |
2011-01-31 |
2023-08-12 |
rat |
| Azza Baraka, Samar ElGhotn. Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats. European journal of pharmacology. vol 641. issue 2-3. 2011-01-31. PMID:20639139. |
administration of studied antidiabetic drugs, glibenclamide and pioglitazone, resulted in significant improvement in spatial cognition and in learning and memory performance, as well as significant decrease in hippocampal hyperphosphorylated tau protein and hippocampal galanin. |
2011-01-31 |
2023-08-12 |
rat |
| Mirsada Caušević, Umbreen Farooq, Simon Lovestone, Richard Killic. β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neuroscience letters. vol 485. issue 3. 2011-01-28. PMID:20826196. |
unexpectedly, protein levels of glycogen synthase kinase 3 (gsk3), a major tau kinase, are at their lowest in hippocampus. |
2011-01-28 |
2023-08-12 |
human |
| Julie Blanchard, Lukas Wanka, Yunn-Chyn Tung, María del Carmen Cárdenas-Aguayo, Frank M LaFerla, Khalid Iqbal, Inge Grundke-Iqba. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta neuropathologica. vol 120. issue 5. 2011-01-25. PMID:20697724. |
although this treatment had no detectable effect on aβ and tau pathologies in 9-month animals, it enhanced neurogenesis in dentate gyrus, reduced ectopic birth in the granular cell layer, and increased neuronal plasticity in the hippocampus and cerebral cortex. |
2011-01-25 |
2023-08-12 |
mouse |
| Zhang Zhang, James W Simpkin. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain research. vol 1359. 2011-01-25. PMID:20807517. |
these data suggest that the unilateral microinfusion of oa into the dorsal hippocampus causes cognitive deficiency, nfts-like pathological changes, and oxidative stress as seen in ad pathology via tau hyperphosphorylation caused by inhibition of protein phosphatases. |
2011-01-25 |
2023-08-12 |
rat |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655383. |
rosiglitazone reduces tau phosphorylation via jnk inhibition in the hippocampus of rats with type 2 diabetes and tau transfected sh-sy5y cells. |
2011-01-12 |
2023-08-12 |
mouse |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655383. |
interestingly, rosiglitazone reduced tau phosphorylation only in the hippocampus of oletf type 2 diabetes rats, and not in that of stz-injected type 1 diabetes mice. |
2011-01-12 |
2023-08-12 |
mouse |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655383. |
the activity of jnk was reduced in the hippocampus of rosiglitazone-treated oletf rats, correlating with a reduction in tau phosphorylation, however, which was not correlated with gsk3β activity. |
2011-01-12 |
2023-08-12 |
mouse |
| Jose F Abisambra, Laura J Blair, Shannon E Hill, Jeffrey R Jones, Clara Kraft, Justin Rogers, John Koren, Umesh K Jinwal, Lisa Lawson, Amelia G Johnson, Donna Wilcock, John C O'Leary, Karen Jansen-West, Martin Muschol, Todd E Golde, Edwin J Weeber, Jessica Banko, Chad A Dicke. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084594. |
moreover, rapid decay in hippocampal long-term potentiation (ltp) intrinsic to this tau transgenic model was rescued by wild-type hsp27 overexpression but not by 3×s/d hsp27. |
2010-12-23 |
2023-08-12 |
mouse |
| Miguel Díaz-Hernández, Alberto Gómez-Ramos, Alicia Rubio, Rosa Gómez-Villafuertes, José R Naranjo, M Teresa Miras-Portugal, Jesús Avil. Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. The Journal of biological chemistry. vol 285. issue 42. 2010-12-07. PMID:20634292. |
however, it has been recently reported that extracellular unmodified tau protein may also induce a neurotoxic effect on hippocampal neurons by activation of m1 and m3 muscarinic receptors. |
2010-12-07 |
2023-08-12 |
Not clear |
| Stacey Fuller, Megan Steele, Gerald Münc. Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? Mutation research. vol 690. issue 1-2. 2010-12-02. PMID:19748514. |
alzheimer's disease (ad) is a neurodegenerative disorder, characterized histopathologically by the extracellular deposition of beta-amyloid peptide in senile plaques, as well as intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau protein, extensive neuronal loss and synaptic changes in the hippocampus and cerebral cortex. |
2010-12-02 |
2023-08-12 |
Not clear |