| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José L Molinuevo Gui. [Role of biomarkers in the early diagnosis of Alzheimer's disease]. Revista espanola de geriatria y gerontologia. vol 46 Suppl 1. 2012-05-07. PMID:22152914. |
the use of biomarkers such as determination of the proteins involved in the disease in cerebrospinal fluid (aβ₄₂-amyloid, total and phosphorylated tau) and measurement of the hippocampus and entorhinal cortex with magnetic resonance imaging and positron emission tomography (both glucose and amyloid measurements), alone or combined, could allow early and etiologic diagnosis. |
2012-05-07 |
2023-08-12 |
Not clear |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. |
2012-05-04 |
2023-08-12 |
rat |
| Kai Liao, Dan Liu, Ling-Qiang Zh. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neuroscience letters. vol 507. issue 1. 2012-05-04. PMID:22155098. |
we found that short-term odor enrichment did not affect the phosphorylation of tau, while long-term odor enrichment dramatically reduce the phosphorylation level of tau at ser198/199/202, thr231, ser396, and ser404 sites both in the hippocampus and cortex. |
2012-05-04 |
2023-08-12 |
rat |
| Hélène Le Freche, Jonathan Brouillette, Francisco-José Fernandez-Gomez, Pauline Patin, Raphaëlle Caillierez, Nadège Zommer, Nicolas Sergeant, Valérie Buée-Scherrer, Gilles Lebuffe, David Blum, Luc Bué. Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment. Anesthesiology. vol 116. issue 4. 2012-05-04. PMID:22343471. |
the main aim of the present study was to investigate effects, in normothermic conditions, of acute or repeated exposure to sevoflurane, a halogenated anesthetic agent, on hippocampal tau phosphorylation and spatial memory in adult mice. |
2012-05-04 |
2023-08-12 |
mouse |
| Yue Wang, Zhe Cheng, Wei Qin, Jianping Ji. Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:21929538. |
additionally, the hyperphosphorylated tau and tangle-like argentophilic structures were detected at ca3 and ca4, but not ca1, region of hippocampus, and we also found tangle-like structure and wizened degenerative neurons in frontal cortex. |
2012-05-03 |
2023-08-12 |
mouse |
| Bin Zhang, Jenna Carroll, John Q Trojanowski, Yuemang Yao, Michiyo Iba, Justin S Potuzak, Anne-Marie L Hogan, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, Kurt R Brunde. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 11. 2012-05-01. PMID:22423084. |
moreover, the epod-treated ps19 mice had less forebrain tau pathology and increased hippocampal neuronal integrity, with no dose-limiting side effects. |
2012-05-01 |
2023-08-12 |
mouse |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22102449. |
the unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. |
2012-04-27 |
2023-08-12 |
Not clear |
| Elisabete Ferreiro, Cláudia M F Pereir. Endoplasmic reticulum stress: a new playER in tauopathies. The Journal of pathology. vol 226. issue 5. 2012-04-27. PMID:22190226. |
the authors described that increased levels of upr activation markers are predominantly observed in neurons within the hippocampus, being correlated with early tau phosphorylation. |
2012-04-27 |
2023-08-12 |
Not clear |
| M Cecilia Ljungberg, Yousuf O Ali, Jie Zhu, Chia-Shan Wu, Kazuhiro Oka, R Grace Zhai, Hui-Chen L. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:22027994. |
both the total amount of phospho-cre binding protein (creb) and the pcreb bound to nmnat2 cre sites in the cortex and the hippocampus of rtg4510 mice are significantly reduced, suggesting that nmnat2 is a direct target of creb under physiological conditions and that tau(p301l) overexpression down-regulates creb-mediated transcription. |
2012-04-26 |
2023-08-12 |
mouse |
| Wagner Zago, Manuel Buttini, Thomas A Comery, Christopher Nishioka, Shyra J Gardai, Peter Seubert, Dora Games, Frédérique Bard, Dale Schenk, Gene G Kinne. Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 8. 2012-04-16. PMID:22357853. |
in the current report, we demonstrated that 3d6 binds to soluble, synaptotoxic assemblies of aβ(1-42) and prevents multiple downstream functional consequences in rat hippocampal neurons including changes in glutamate ampa receptor trafficking, ad-type tau phosphorylation, and loss of dendritic spines. |
2012-04-16 |
2023-08-12 |
mouse |
| Alix de Calignon, Manuela Polydoro, Marc Suárez-Calvet, Christopher William, David H Adamowicz, Kathy J Kopeikina, Rose Pitstick, Naruhiko Sahara, Karen H Ashe, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. vol 73. issue 4. 2012-04-16. PMID:22365544. |
tau pathology progresses from ec transgene-expressing neurons to neurons without detectable transgene expression, first to ec neighboring cells, followed by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, ca fields of the hippocampus, and cingulate cortex. |
2012-04-16 |
2023-08-12 |
mouse |
| Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riede. Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096518. |
plb1(triple) mice presented with stable gene expression and age-related pathology of intra-neuronal amyloid and hyperphosphorylated tau in hippocampus and cortex from 6 months onwards. |
2012-04-10 |
2023-08-12 |
mouse |
| Ian T Marsden, Laurie S Minamide, James R Bambur. Amyloid-β-induced amyloid-β secretion: a possible feed-forward mechanism in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 24. issue 4. 2012-04-09. PMID:21297255. |
human aβd/t increased >2 fold the aβ secreted by organotypic hippocampal slices from tau knock-out mice whether or not they expressed a human tau transgene, suggesting tau plays no role in enhanced aβ secretion. |
2012-04-09 |
2023-08-12 |
mouse |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was compared with the sequential emergence of other tau modifications in the alzheimer's disease hippocampus using monoclonal antibodies to multiple well-characterized tau epitopes. |
2012-04-09 |
2023-08-12 |
Not clear |
| Yuu Yamazaki, Tomoyasu Matsubara, Tetsuya Takahashi, Takashi Kurashige, Eisuke Dohi, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. PloS one. vol 6. issue 11. 2012-03-26. PMID:22073234. |
granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. |
2012-03-26 |
2023-08-12 |
Not clear |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
to model the hippocampal neurodegeneration and memory-related behavioral impairment that occurs in ftld and other tau and tdp-43 proteinopathy diseases, we used an adeno-associated virus serotype 9 (aav9) vector to induce bilateral expression of either microtubule-associated protein tau or transactive response dna binding protein 43 kda (tdp-43) in adult rat dorsal hippocampus. |
2012-03-26 |
2023-08-12 |
human |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
the data demonstrate that tdp-43 produced mild behavioral impairment and hippocampal neurodegeneration in rats, whereas tau did not. |
2012-03-26 |
2023-08-12 |
human |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22177996. |
the models could be of value for studying mechanisms of ftld and other diseases with tau and tdp-43 pathology in the hippocampus including alzheimer's disease, with relevance to early stage mild impairment. |
2012-03-26 |
2023-08-12 |
human |
| Ana Paula Costa, Ana Carolina Tramontina, Regina Biasibetti, Cristiane Batassini, Mark William Lopes, Krista Minéia Wartchow, Caren Bernardi, Lucas Silva Tortorelli, Rodrigo Bainy Leal, Carlos-Alberto Gonçalve. Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia. Behavioural brain research. vol 226. issue 2. 2012-03-25. PMID:21982813. |
memory impairment induced by intra-hippocampal injection of oa has been reported, accompanied by remarkable neuropathological changes including hippocampal neurodegeneration, a paired helical filament-like phosphorylation of tau protein, and formation of β-amyloid containing plaque-like structures. |
2012-03-25 |
2023-08-12 |
rat |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
role of tau protein on neocortical and hippocampal oscillatory patterns. |
2012-03-16 |
2023-08-12 |
mouse |