| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Zhukareva, Keyur Shah, Kunihiro Uryu, Heiko Braak, Kelly Del Tredici, Sonali Sundarraj, Christopher Clark, John Q Trojanowski, Virginia M-Y Le. Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. The American journal of pathology vol 161 issue 4 2002 12368187 |
analyses of separately dissected gray and white matter samples from various cortical regions revealed that pathological tau in argyrophilic grain disease was confined primarily to mediotemporal neocortical gray and adjacent white matter, and also to the allocortex, amygdala, and hippocampus. |
2002-11-05 |
2023-01-24 |
Not clear |
| Quanbao Wang, Jianzhi Wan. Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of Tau and abnormal behavior in rats. Chinese medical journal vol 115 issue 6 2002 12123558 |
injection of bradykinin or cyclosporine a to hippocampus induces alzheimer-like phosphorylation of tau and abnormal behavior in rats. |
2002-08-13 |
2023-01-24 |
rat |
| Luigia Trabace, Tommaso Cassano, Antonia Loverre, Luca Steardo, Vincenzo Cuom. CHF2819: pharmacological profile of a novel acetylcholinesterase inhibitor. CNS drug reviews vol 8 issue 1 2002 12070526 |
by oral administration to young adult rats chf2819 did not affect extracellular hippocampal levels of glutamate (glu), aspartate (asp), gamma-aminobutyric acid (gaba), taurine (tau), arginine (arg) or citrulline (cit). |
2002-08-09 |
2023-01-24 |
rat |
| Victoria Zhukareva, David Mann, Stuart Pickering-Brown, Kunihiro Uryu, Theresa Shuck, Keyur Shah, Murray Grossman, Bruce L Miller, Christine M Hulette, Stuart C Feinstein, John Q Trojanowski, Virginia M-Y Le. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Annals of neurology vol 51 issue 6 2002 12112079 |
therefore, pick's disease is characterized by an accumulations of pick bodies in the hippocampal region and cortex as well as the presence of three and four microtubule-binding repeat tau pathology in both cortical gray and white matter that distinguish this tauopathy from other neurodegenerative disorders. |
2002-08-09 |
2023-01-24 |
Not clear |
| R Sinigaglia-Coimbra, E A Cavalheiro, C G Coimbr. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain. Acta neuropathologica vol 103 issue 5 2002 11935259 |
associated immunohistochemical findings after 2 or 6 months of recovery included: (1) complement activation (membrane attack complex formation); (2) generalized overexpression of ubiquitin in surviving forebrain neurons; (3) persistent activation of macrophages; (4) presence of gemistocytic astrocytes in the hippocampus; (5) maturation of amyloid plaques (identified by immunohistochemistry using anti-human beta-a4 primary antibody) in cerebral cortex; and (6) intracellular deposits identified by anti-human hyperphosphorylated tau protein antibodies. |
2002-06-21 |
2023-01-24 |
rat |
| Eizo Iseki, Noriko Takayama, Wami Marui, Kenji U\\xc3\\xa9da, Kenji Kosak. Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains. Journal of the neurological sciences vol 195 issue 1 2002 11867079 |
using tau immunohistochemistry and alpha-synuclein immunohistochemistry, we quantitatively investigated the most frequent sites and the formation process of neurofibrillary tangles (nft) and lewy bodies (lb) in the hippocampus from 20 patients with dementia with lewy bodies (dlb). |
2002-05-07 |
2023-01-24 |
Not clear |
| H C Baxter, W-G Liu, J L Forster, A Aitken, J R Frase. Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain. Neuroscience vol 109 issue 1 2002 11784696 |
the tau isoform was found only in the hippocampus and medulla, and the epsilon isoform was found throughout grey matter of the cns. |
2002-04-11 |
2023-01-24 |
Not clear |
| C Gonz\\xc3\\xa1lez-Billault, M Engelke, E M Jim\\xc3\\xa9nez-Mateos, F Wandosell, A C\\xc3\\xa1ceres, J Avil. Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. Journal of neuroscience research vol 67 issue 6 2002 11891784 |
in this report we have characterized the effect of the combined suppression of map1b and tau, and map1b and map2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing substrate. |
2002-04-09 |
2023-01-24 |
mouse |
| Steven M Singer, Gina M Zainelli, Maryam A Norlund, John M Lee, Nancy A Mum. Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease. Neurochemistry international vol 40 issue 1 2002 11738469 |
in control cases with nft present in the entorhinal cortex and hippocampus, indicative of braak and braak stage ii, epsilon(gamma-glutamyl)lysine bonds were present in phf tau in parietal and frontal cortex, despite the lack of microscopically detectable nft or senile plaques in these cortical regions. |
2002-03-06 |
2023-01-24 |
Not clear |
| I K Takeuchi, Y K Takeuch. Transient accumulation of Gallyas-Braak-positive and phosphorylated tau-immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex of rats during long-term chloroquine intoxication. Acta neuropathologica vol 102 issue 2 2002 11563636 |
long-term chloroquine (cq) intoxication of normal and groggy mutant rats resulted in transient accumulation of gallyas-braak (g-b) -positive and phosphorylated tau (at8) -immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex. |
2002-02-25 |
2023-01-24 |
rat |
| Kentaro Tanemura, Miyuki Murayama, Takumi Akagi, Tsutomu Hashikawa, Takashi Tominaga, Michinori Ichikawa, Haruyasu Yamaguchi, Akihiko Takashim. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 22 issue 1 2002 11756496 |
v337m tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for nfts in human neurodegenerative diseases. |
2002-02-04 |
2023-01-24 |
mouse |
| R B Maccioni, J P Mu\\xc3\\xb1oz, L Barbeit. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Archives of medical research vol 32 issue 5 2001 11578751 |
experiments with hippocampal cells in culture have indicated a relationship between fibrillary amyloid and the cascade of molecular signals that trigger tau hyperphosphorylations. |
2001-12-04 |
2023-01-24 |
human |
| E Planel, K Yasutake, S C Fujita, K Ishigur. Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. The Journal of biological chemistry vol 276 issue 36 2001 11441005 |
inhibition of protein phosphatase 2a overrides tau protein kinase i/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. |
2001-10-11 |
2023-01-24 |
mouse |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research vol 907 issue 1-2 2001 11430905 |
expression of amyloid precursor protein, tau and presenilin rnas in rat hippocampus following deafferentation lesions. |
2001-10-04 |
2023-01-24 |
rat |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research vol 907 issue 1-2 2001 11430905 |
tau mrna level in hippocampus was unchanged after lesions. |
2001-10-04 |
2023-01-24 |
rat |
| M Yamada, Y Itoh, N Sodeyama, N Suematsu, E Otomo, M Matsushita, H Mizusaw. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dementia and geriatric cognitive disorders vol 12 issue 2 2001 11173884 |
to elucidate the pathogenesis of sd-nft in comparison with alzheimer's disease (ad), we investigated the hippocampal lesions and analyzed the tau gene. |
2001-07-12 |
2023-01-24 |
human |
| R K Ellerkmann, V Riazanski, C E Elger, B W Urban, H Bec. Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells. The Journal of physiology vol 532 issue Pt 2 2001 11306658 |
in isolated hippocampal dentate granule cells (dgcs), recovery from this inactivation was biexponential, with time constants for the two phases of slow inactivation tau(slow,1) and tau(slow,2) ranging from 1 to 10 s and 20 to 50 s, respectively. |
2001-06-14 |
2023-01-24 |
rat |
| A K Mudher, B Yee, A D Smith, V H Perr. Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat. Neuroscience letters vol 301 issue 1 2001 11239703 |
to investigate what effect deafferentation of the hippocampus has on the phosphorylation state of tau, we lesioned the entorhinal cortex in rats and looked for hyperphosphorylated tau in the hippocampus at various days post lesioning. |
2001-06-07 |
2023-01-24 |
rat |
| C X Gong, T Lidsky, J Wegiel, I Grundke-Iqbal, K Iqba. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain research. Brain research protocols vol 6 issue 3 2001 11223412 |
selective inhibition of protein phosphatase 2a in these rat brain slices by the treatment with okadaic acid induced hyperphosphorylation of tau at many abnormal sites seen in alzheimer's disease brain and the accumulation of hyperphosphorylated tau in pyramidal neurons of the cortex and hippocampus. |
2001-05-24 |
2023-01-24 |
rat |
| V Vogelsberg-Ragaglia, T Schuck, J Q Trojanowski, V M Le. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Experimental neurology vol 168 issue 2 2001 11259128 |
since abnormal tau phosphorylation may play a role in neurofibrillary tangle (nft) formation in aging and alzheimer's disease (ad), we probed the distribution and abundance of protein phosphatase 2a (pp2a) catalytic (calpha) and regulatory (pr55alpha and gamma, pr61varepsilon and delta) subunit mrna in control and ad hippocampus using in situ hybridization. |
2001-05-10 |
2023-01-24 |
Not clear |