| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Possemato Elena, La Barbera Livia, Nobili Annalisa, Krashia Paraskevi, D'Amelio Marcell. The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases. Ageing research reviews. 2023-03-09. PMID:36893920. |
the persistent and uncontrolled nlrp3 inflammasome activation has a leading role during the pathophysiology of neuroinflammation in age-related neurodegenerative diseases such as parkinson's (pd) and alzheimer's (ad). |
2023-03-09 |
2023-08-14 |
Not clear |
| Jinjian Wu, Yuqi Fang, Xin Tan, Shangyu Kang, Xiaomei Yue, Yawen Rao, Haoming Huang, Mingxia Liu, Shijun Qiu, Pew-Thian Ya. Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity. Scientific reports. vol 13. issue 1. 2023-03-09. PMID:36894561. |
resting-state functional magnetic resonance imaging (rs-fmri) is used to diagnose neurodegenerative diseases, such as cognitive impairment (ci), alzheimer's disease (ad), and vascular dementia (vad). |
2023-03-09 |
2023-08-14 |
Not clear |
| b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' |
currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. |
2023-03-06 |
2023-08-14 |
Not clear |
| Eric Goffin, Pierre Fraikin, Dayana Abboud, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Julien Hanson, Laurence Danober, Pierre Francotte, Bernard Pirott. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European journal of medicinal chemistry. vol 250. 2023-03-02. PMID:36863228. |
positive allosteric modulators of the ampa receptors (ampar pams) have been proposed as new drugs for the management of various neurodegenerative diseases such as alzheimer's disease, parkinson's disease, attention deficit hyperactivity disorder, depression, and schizophrenia. |
2023-03-02 |
2023-08-14 |
mouse |
| Xiuli Dan, Beimeng Yang, Ross A McDevitt, Samuel Gray, Xixia Chu, Quia Claybourne, David M Figueroa, Yongqing Zhang, Deborah L Croteau, Vilhelm A Boh. Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice. Aging cell. 2023-02-27. PMID:36846960. |
olfactory dysfunction is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including alzheimer's and parkinson's diseases. |
2023-02-27 |
2023-08-14 |
mouse |
| Władysław Lasoń, Danuta Jantas, Monika Leśkiewicz, Magdalena Regulska, Agnieszka Basta-Kai. The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer's and Parkinson's Diseases: A Narrative Review. Cells. vol 12. issue 4. 2023-02-25. PMID:36831327. |
the vitamin d receptor as a potential target for the treatment of age-related neurodegenerative diseases such as alzheimer's and parkinson's diseases: a narrative review. |
2023-02-25 |
2023-08-14 |
Not clear |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
alzheimer's disease (ad) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated tau proteins. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yousra El Ouaamari, Jasper Van den Bos, Barbara Willekens, Nathalie Cools, Inez Wen. Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835277. |
neurodegenerative diseases, including alzheimer's disease (ad), parkinson's disease (pd), huntington's disease (hd), multiple sclerosis (ms), spinal cord injury (sci), and amyotrophic lateral sclerosis (als), are characterized by acute or chronic progressive loss of one or several neuronal subtypes. |
2023-02-25 |
2023-08-14 |
Not clear |
| Abhishek Dahal, Karthivashan Govindarajan, Satyabrata Ka. Administration of kainic acid differentially alters astrocyte markers and transiently enhanced phospho-tau level in adult rat hippocampus. Neuroscience. 2023-02-22. PMID:36805001. |
additionally, a role for microtubule associated tau protein, involved in various neurodegenerative diseases including alzheimer's disease, has also been suggested in the development of seizure and/or neurodegeneration in tle pathogenesis. |
2023-02-22 |
2023-08-14 |
human |
| Faizal Hajamohideen, Noushath Shaffi, Mufti Mahmud, Karthikeyan Subramanian, Arwa Al Sariri, Viswan Vimbi, Abdelhamid Abdessela. Four-way classification of Alzheimer's disease using deep Siamese convolutional neural network with triplet-loss function. Brain informatics. vol 10. issue 1. 2023-02-22. PMID:36806042. |
alzheimer's disease (ad) is a neurodegenerative disease that causes irreversible damage to several brain regions, including the hippocampus causing impairment in cognition, function, and behaviour. |
2023-02-22 |
2023-08-14 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
an antidiabetic agent sodium glucose co-transporter 2 (sglt2) inhibitor ertugliflozin has been revealed to bind to catalytic anionic site of acetylcholinesterase (ache), which is considered to be associated with the cognitive decline in neurodegenerative diseases, such as alzheimer's disease (ad). |
2023-02-22 |
2023-08-14 |
rat |
| Daniela Jimenez-Harrison, Carol J Huseby, Claire N Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, Jeff Kure. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Biochemistry. 2023-02-22. PMID:36813261. |
tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Kariem Ezzat, Andrea Sturchio, Alberto J Espa. The shift to a proteinopenia paradigm in neurodegeneration. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803814. |
we therefore advocate for a paradigm shift from proteinopathy (gof) to proteinopenia (lof) based on the universal depletion of soluble functional proteins in neurodegenerative diseases (low amyloid-β 42 in alzheimer's disease, low α-synuclein in parkinson's disease, and low tau in progressive supranuclear palsy) and supported by the confluence of biologic, thermodynamic, and evolutionary principles with proteins having evolved to perform a function, not to become toxic, and where protein depletion is consequential. |
2023-02-21 |
2023-08-14 |
Not clear |
| Ya-Jing Liu, Yu Ding, Yan-Qing Yin, Hui Xiao, Gang Hu, Jia-Wei Zho. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 8. 2023-02-16. PMID:36795751. |
microglia play a critical role in the pathogenic process of neurodegenerative diseases, such as parkinson's disease (pd) and alzheimer's disease (ad). |
2023-02-16 |
2023-08-14 |
Not clear |
| Asmaa K Abdelghany, Amr Gamal, Ahmed Abdel-Wahab, Abdel-Razik H Abdel-Razik, Salma I El-Samannoudy, Marwa A Ibrahim, Walid Hamdy Hassan, Fatma I Abo El-El. Evaluating the neuroprotective effect of Spirulina platensis-loaded niosomes against Alzheimer's disease induced in rats. Drug delivery and translational research. 2023-02-15. PMID:36790720. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that is characterized by memory loss, changes in behavior, and avoidance of social bonds. |
2023-02-15 |
2023-08-14 |
rat |
| Yi Jayne Tan, Isabel Siow, Seyed Ehsan Saffari, Simon K S Ting, Zeng Li, Nagaendran Kandiah, Louis C S Tan, Eng King Tan, Adeline S L N. Plasma Soluble ST2 Levels Are Higher in Neurodegenerative Disorders and Associated with Poorer Cognition. Journal of Alzheimer's disease : JAD. 2023-02-13. PMID:36776067. |
high sst2 levels have been reported in mild cognitive impairment (mci) and alzheimer's disease (ad), suggesting that the il-33/st2 signaling pathway may be implicated in neurodegenerative diseases. |
2023-02-13 |
2023-08-14 |
Not clear |
| Irene Fatuzzo, Giovanni Francesco Niccolini, Federica Zoccali, Luca Cavalcanti, Mario Giuseppe Bellizzi, Gabriele Riccardi, Marco de Vincentiis, Marco Fiore, Carla Petrella, Antonio Minni, Christian Barbat. Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768440. |
olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction is one of the early signs of prodromal neurodegenerative diseases such as alzheimer's and parkinson's disease. |
2023-02-11 |
2023-08-14 |
Not clear |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
heterozygous loss-of-function mutations in trem2, including mutations enhancing shedding form the cell surface, have been associated with myelin/neuronal loss and neuroinflammation in neurodegenerative diseases, such as alzheimer`s disease and frontotemporal dementia. |
2023-02-09 |
2023-08-14 |
mouse |
| Xiaolin Dong, Yanping Li, Qingyun Li, Wenhao Li, Gang W. Identification of immune signatures in Parkinson's disease based on co-expression networks. Frontiers in genetics. vol 14. 2023-02-03. PMID:36733342. |
in addition, functional analysis indicated that module genes were involved in various neurodegenerative diseases, such as alzheimer disease, huntington disease, parkinson disease, and long-term depression. |
2023-02-03 |
2023-08-14 |
human |
| Estefania Fuentes, Berenice Venegas, Guadalupe Muñoz-Arenas, Carolina Moran, Rubén A Vazquez-Roque, Gonzalo Flores, Samuel Treviño, Alfonso Diaz, Jorge Guevar. HIGH-CARBOHYDRATE AND FAT DIET CONSUMPTION CAUSES METABOLIC DETERIORATION, NEURONAL DAMAGE, AND LOSS OF RECOGNITION MEMORY IN RATS. Journal of chemical neuroanatomy. 2023-02-03. PMID:36736441. |
in recent years, it has been reported that alterations in insulin at the brain level could have an impact on the appearance of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, dementia, depression, and other types of disorders that compromise brain function. |
2023-02-03 |
2023-08-14 |
rat |