| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne-Marie Jacobsen, Nico C van de Merbel, Dorte K Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T Pedersen, Nina Rosenqvis. A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396. Journal of the American Society for Mass Spectrometry. 2023-01-31. PMID:36719168. |
hyperphosphorylated tau protein is well-known to be involved in the formation of neurofibrillary tangles and the progression of age-related neurodegenerative diseases (tauopathies), including alzheimer's disease (ad). |
2023-01-31 |
2023-08-14 |
mouse |
| Zachery D Morrissey, Jin Gao, Liang Zhan, Weiguo Li, Igor Fortel, Takaomi Saido, Takashi Saito, Arnold Bakker, Scott Mackin, Olusola Ajilore, Orly Lazarov, Alex D Leo. Hippocampal functional connectivity across age in an Frontiers in aging neuroscience. vol 14. 2023-01-30. PMID:36711209. |
hippocampal functional connectivity across age in an alzheimer's disease (ad) is a progressive neurodegenerative disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Ping-Tao Tseng, Yen-Wen Chen, Bing-Yan Zeng, Bing-Syuan Zeng, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F Carvalho, Andre R Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Che-Sheng Chu, Mein-Woei Suen, Cheng-Ta L. The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-26. PMID:36698219. |
dementia [i.e., alzheimer disease (ad)], the most common neurodegenerative disease, causes profound negative impacts on executive function and quality of life. |
2023-01-26 |
2023-08-14 |
Not clear |
| Aleksandra Parka, Caroline Degel, Jakob Dreyer, Ulrike Richter, Benjamin Hall, Jesper F Bastlund, Bettina Laursen, Maiken Nedergaard, Florence Sotty, Paolo Bott. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model. Neurobiology of disease. vol 178. 2023-01-25. PMID:36696792. |
tau protein pathology is a hallmark of many neurodegenerative diseases, including alzheimer's disease or frontotemporal dementia. |
2023-01-25 |
2023-08-14 |
mouse |
| Susanna P Garamszegi, Sandra Anne Banack, Linda L Duque, James S Metcalf, Elijah W Stommel, Paul Alan Cox, David A Davi. Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer's disease patients using UHPLC-MS/MS: An autopsy case-series study. Toxicology reports. vol 10. 2023-01-24. PMID:36691605. |
here, we present a case series study evaluating exposure to β-n-methylamino-l-alanine (bmaa), a cyanobacterial toxin linked to neurodegenerative disease, in postmortem olfactory tissues of individuals with varying stages of alzheimer's disease (ad). |
2023-01-24 |
2023-08-14 |
Not clear |
| Peter Wostyn, Piet Goddae. Can Immersive Sound Therapy Counteract Neurodegeneration by Enhancing Glymphatic Clearance? Comment on Sachdeva et al. Effects of Sound Interventions on the Permeability of the Blood-Brain Barrier and Meningeal Lymphatic Clearance. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672079. |
we fully agree with this notion, since we recently hypothesized that immersive sound therapy may be an innovative approach to reduce the individual risk of developing neurodegenerative diseases, such as alzheimer's disease, by inducing eeg slow-wave delta oscillations (which characterize deep sleep), thereby promoting glymphatic clearance. |
2023-01-21 |
2023-08-14 |
Not clear |
| Marzie Khavandi, Praveen P N Rao, Michael A Beazel. Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674424. |
the regulation and metabolism of the endocannabinoid system has received extensive attention for their potential neuroprotective effect in neurodegenerative diseases such as alzheimer's disease (ad), which is characterized by amyloid β (aβ) -induced cell toxicity, inflammation, and oxidative stress. |
2023-01-21 |
2023-08-14 |
mouse |
| Ashraf K El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keu. Identification of New Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678580. |
identification of new monoamine oxidase-b (mao-b), acetylcholinesterase (ache), and butyrylcholinesterase (bche) have been considered target enzymes of depression and neurodegenerative diseases, including alzheimer's disease (ad). |
2023-01-21 |
2023-08-14 |
Not clear |
| Jing Zhang, Jie Li, Pan You, Haitian Jiang, Yanjun Liu, Daobin Han, Meiqi Liu, Hui Yu, Bo S. Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum. Biochimica et biophysica acta. Molecular basis of disease. 2023-01-20. PMID:36669576. |
hyperphosphorylated rab10 has been implicated in the pathogenesis of neurodegenerative diseases, such as parkinson's disease and alzheimer's disease. |
2023-01-20 |
2023-08-14 |
mouse |
| Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Göt. Tyrosine phosphatase STEP Molecular brain. vol 16. issue 1. 2023-01-13. PMID:36639708. |
tyrosine phosphatase step synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia with tau pathology (ftd-tau), a group of primary tauopathies. |
2023-01-13 |
2023-08-14 |
Not clear |
| Xin Liu, Weiyi She, Herman H-Y Sung, Ian D Williams, Peiyuan Qia. Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage. International journal of biological macromolecules. 2023-01-09. PMID:36621732. |
alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by tau aggregating into neurofibrillary tangles. |
2023-01-09 |
2023-08-14 |
Not clear |
| Natalia Pieńkowska, Margaret Fahnestock, Crystal Mahadeo, Izabela Zaborniak, Paweł Chmielarz, Grzegorz Bartosz, Izabela Sadowska-Bartos. Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613801. |
abnormally phosphorylated tau protein is the principal component of neurofibrillary tangles, accumulating in the brain in many neurodegenerative diseases, including alzheimer's disease. |
2023-01-08 |
2023-08-14 |
human |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. |
2023-01-07 |
2023-08-14 |
mouse |
| Yujia Xi, Yuyu Zhang, Yiwen Zhou, Qing Liu, Xuhui Chen, Xuebo Liu, Tilman Grune, Lin Shi, Min Hou, Zhigang Li. Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer's Disease model mice: Role of the cystathionine-β-synthase/H Redox biology. vol 59. 2023-01-06. PMID:36608589. |
however, the effects of mr on alleviating neurodegenerative diseases such as alzheimer's disease (ad) are largely unexplored. |
2023-01-06 |
2023-08-14 |
mouse |
| Pan Wang, Shuman Zhang, Chunli Hu, Lili Ren, Jing B. Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ Molecular biology reports. 2023-01-05. PMID:36602704. |
regulatory role of melatonin in notch1 signaling pathway in cerebral cortex of aβ soluble amyloid-beta (aβ) oligomers are thought to play a key role in the pathogenesis of alzheimer's disease (ad), which is the most common age-associated neurodegenerative diseases with obvious neuropathological changes and functional decline in both cortical and subcortical regions. |
2023-01-05 |
2023-08-14 |
Not clear |
| b' \\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer\'s in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology. 2023-01-03. PMID:36594931.' |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss and cognitive decline, with hallmark pathologies related to amyloid beta (aβ) and tau. |
2023-01-03 |
2023-08-14 |
rat |
| Avnish Kumar Verma, Sandeep Singh, Syed Ibrahim Rizv. Aging, circadian disruption and neurodegeneration: Interesting interplay. Experimental gerontology. 2022-12-27. PMID:36574855. |
furthermore, we summarize recent evidence suggesting that cd may also be a predisposing factor for the development of age-related neurodegenerative diseases (ndds) such as alzheimer's disease (ad), parkinson's disease (pd), and huntington's disease (hd), although more investigation is required to prove this link. |
2022-12-27 |
2023-08-14 |
Not clear |
| Louise Bryan, Saurabh Awasthi, Yuanjie Li, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Maye. Site-Specific C-Terminal Fluorescent Labeling of Tau Protein. ACS omega. vol 7. issue 50. 2022-12-26. PMID:36570287. |
formation of tau protein aggregates in neurons is a pathological hallmark of several neurodegenerative diseases, including alzheimer's disease. |
2022-12-26 |
2023-08-14 |
Not clear |
| Fernando Gonzalez-Ortiz, Michael Turton, Przemysław R Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. Brain : a journal of neurology. 2022-12-26. PMID:36572122. |
furthermore, plasma brain-derived tau accurately distinguished autopsy-confirmed alzheimer's disease from other neurodegenerative diseases (area under the curve = 86.4%) while neurofilament light did not (area under the curve = 54.3%). |
2022-12-26 |
2023-08-14 |
human |