| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843008. |
similarly, we observed an interaction between sex and total tau level on longitudinal hippocampal atrophy (p = 0.008), and longitudinal decline in executive function (p = 0.034). |
2018-01-25 |
2023-08-13 |
human |
| Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843008. |
women with aβ-42 and total tau levels indicative of worse pathological changes showed more rapid hippocampal atrophy and cognitive decline. |
2018-01-25 |
2023-08-13 |
human |
| J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research. vol 313. 2018-01-25. PMID:27449203. |
hippocampal aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly i:c administration. |
2018-01-25 |
2023-08-13 |
Not clear |
| J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research. vol 313. 2018-01-25. PMID:27449203. |
immediately after testing, the hippocampus was collected to quantify aβ and phosphorylated tau accumulation. |
2018-01-25 |
2023-08-13 |
Not clear |
| Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298664. |
a total of 1718 participants from the adni cohort were selected, and we evaluated the impact of ε4 dose on cerebrospinal fluid (csf) levels' abeta1-42 (aβ1-42), tau, and phosphorylated-tau (p-tau); cortical amyloid deposition (florbetapir-pet-av45); brain atrophy (mri); brain metabolism (fdg-pet); hippocampal metabolism; and cognitive declines, through different cognitive subgroups. |
2018-01-16 |
2023-08-13 |
human |
| Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298664. |
we found that (1) ε4 was associated with decreased csf beta-amyloid (aβ1-42) and increased cerebral aβ deposition across the ad spectrum; (2) increased csf tau, p-tau and cerebral hypometabolism, hippocampal atrophy, and cognition decline were all associated with apoe ε4 in prodromal ad stage; (3) increased csf tau, p-tau and cerebral hypometabolism appear to begin earlier than hippocampal atrophy and cognitive decline. |
2018-01-16 |
2023-08-13 |
human |
| Sara Pinheiro, Joana Silva, Cristina Mota, João Vaz-Silva, Ana Veloso, Vítor Pinto, Nuno Sousa, João Cerqueira, Ioannis Sotiropoulo. Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26328538. |
tau mislocation in glucocorticoid-triggered hippocampal pathology. |
2018-01-16 |
2023-08-13 |
rat |
| Sara Pinheiro, Joana Silva, Cristina Mota, João Vaz-Silva, Ana Veloso, Vítor Pinto, Nuno Sousa, João Cerqueira, Ioannis Sotiropoulo. Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26328538. |
we demonstrate, both by biochemical and ultrastructural analysis, that gc administration led to cytosolic and dendritic tau accumulation in rat hippocampus, and triggered tau hyperphosphorylation in epitopes related to its malfunction (ser396/404) and cytoskeletal pathology (e.g., thr231 and ser262). |
2018-01-16 |
2023-08-13 |
rat |
| Lin-Tao Zhou, Shun-Hua Ye, Hai-Xuan Yang, Yong-Ting Zhou, Qi-Hua Zhao, Wei-Wen Sun, Mei-Mei Gao, Yong-Hong Yi, Yue-Sheng Lon. A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14. Neuroscience. vol 349. 2018-01-16. PMID:28257890. |
we show that the relative skipping/inclusion ratio of the micro-exon l in the protrudin gene and exon 10 in the tau gene decreased in the hippocampus of fmr1 knockout (ko) mice. |
2018-01-16 |
2023-08-13 |
mouse |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26883430. |
moreover, atorvastatin significantly attenuated aβ1-42 accumulation and phosphorylation of tau (ser396) in the hippocampus and prefrontal cortex of tg app/ps1 mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 39. issue 4. 2018-01-12. PMID:28083916. |
we propose that an increase in tau acetylated on these lysines blocks the expression of long-term potentiation at hippocampal synapses leading to impaired memory in ad. |
2018-01-12 |
2023-08-13 |
Not clear |
| Julia Gerson, Diana L Castillo-Carranza, Urmi Sengupta, Riddhi Bodani, Donald S Prough, Douglas S DeWitt, Bridget E Hawkins, Rakez Kaye. Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice. Journal of neurotrauma. vol 33. issue 22. 2018-01-10. PMID:26729399. |
tau oligomer levels increased in the hippocampal injection sites and cerebellum, suggesting that tau oligomers may be responsible for seeding the spread of pathology post-tbi. |
2018-01-10 |
2023-08-13 |
mouse |
| Mar Cuadrado-Tejedor, Carolina Garcia-Barroso, Juan A Sánchez-Arias, Obdulia Rabal, Marta Pérez-González, Sara Mederos, Ana Ugarte, Rafael Franco, Victor Segura, Gertrudis Perea, Julen Oyarzabal, Ana Garcia-Ost. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550730. |
chronic treatment of tg2576 mice with cm-414 diminished brain aβ and tau phosphorylation (ptau) levels, increased the inactive form of gsk3β, reverted the decrease in dendritic spine density on hippocampal neurons, and reversed their cognitive deficits, at least in part by inducing the expression of genes related to synaptic transmission. |
2018-01-05 |
2023-08-13 |
mouse |
| FangFang, Hongyan Li, Tingting Qin, Min Li, Shiping M. Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. Metabolic brain disease. vol 32. issue 2. 2018-01-05. PMID:27761760. |
meanwhile, thymol improved the cognitive impairments in the morris water maze (mwm) test and decreased hfd-induced aβ deposition and tau hyperphosphorylation in the hippocampus, which may be correlated with the inhibition of hippocampal oxidative stress and inflammation. |
2018-01-05 |
2023-08-13 |
mouse |
| Jee Hyun Yi, Christopher Brown, Garry Whitehead, Thomas Piers, Young Seok Lee, Celia Martinez Perez, Philip Regan, Daniel J Whitcomb, Kwangwook Ch. Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. Pharmacological research. vol 121. 2018-01-05. PMID:28416463. |
glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. |
2018-01-05 |
2023-08-13 |
Not clear |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging. vol 57. 2018-01-03. PMID:28609678. |
in this report, we investigated endocrine mechanisms for hippocampal tau phosphorylation in db/db and wild-type mice. |
2018-01-03 |
2023-08-13 |
mouse |
| Aditi Dey, Shuai Hao, Marlena Wosiski-Kuhn, Alexis M Stranaha. Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging. vol 57. 2018-01-03. PMID:28609678. |
by separately manipulating peripheral and intrahippocampal corticosterone levels, we determined that hippocampal corticosteroid exposure promotes tau phosphorylation and activates glycogen synthase kinase 3β (gsk3β). |
2018-01-03 |
2023-08-13 |
mouse |
| Francesco Tamagnini, Darren A Walsh, Jon T Brown, Marie K Bondulich, Diane P Hanger, Andrew D Randal. Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein. Neurobiology of aging. vol 60. 2018-01-03. PMID:28917666. |
hippocampal neurophysiology is modified by a disease-associated c-terminal fragment of tau protein. |
2018-01-03 |
2023-08-13 |
mouse |
| Kyoung A Jhang, Jin-Sun Park, Hee-Sun Kim, Young Hae Chon. Resveratrol Ameliorates Tau Hyperphosphorylation at Ser396 Site and Oxidative Damage in Rat Hippocampal Slices Exposed to Vanadate: Implication of ERK1/2 and GSK-3β Signaling Cascades. Journal of agricultural and food chemistry. vol 65. issue 44. 2018-01-03. PMID:29022339. |
resveratrol ameliorates tau hyperphosphorylation at ser396 site and oxidative damage in rat hippocampal slices exposed to vanadate: implication of erk1/2 and gsk-3β signaling cascades. |
2018-01-03 |
2023-08-13 |
rat |
| Vega García-Escudero, Ricardo Gargini, Patricia Martín-Maestro, Esther García, Ramón García-Escudero, Jesús Avil. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neuroscience letters. vol 655. 2018-01-01. PMID:28689927. |
to explain this apparently contradictory result, we studied mapt mrna stoichiometry in coding and non-coding regions, and found that the 3'utr-to-cds ratio was higher in the hippocampus of alzheimer disease patients, with higher tau protein but lower total mrna levels. |
2018-01-01 |
2023-08-13 |
mouse |