| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Hirase, Takayuki Ishida, Chiaki Kame. Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats. European journal of pharmacology. vol 597. issue 1-3. 2008-12-16. PMID:18789918. |
furthermore, the 5-ht(1a) agonist, tandospirone, caused no rebound phenomenon regarding sleep latency in rats. |
2008-12-16 |
2023-08-12 |
rat |
| Małgorzata Jarończyk, Zdzisław Chilmonczyk, Aleksander P Mazurek, Gabriel Nowak, Aina W Ravna, Kurt Kristiansen, Ingebrigt Sylt. The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & medicinal chemistry. vol 16. issue 20. 2008-12-15. PMID:18812261. |
the molecular interactions of buspirone analogues with the serotonin transporter. |
2008-12-15 |
2023-08-12 |
Not clear |
| Małgorzata Jarończyk, Zdzisław Chilmonczyk, Aleksander P Mazurek, Gabriel Nowak, Aina W Ravna, Kurt Kristiansen, Ingebrigt Sylt. The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & medicinal chemistry. vol 16. issue 20. 2008-12-15. PMID:18812261. |
the anxiolytic drug buspirone is known as 5-ht(1a) partial agonist. |
2008-12-15 |
2023-08-12 |
Not clear |
| Małgorzata Jarończyk, Zdzisław Chilmonczyk, Aleksander P Mazurek, Gabriel Nowak, Aina W Ravna, Kurt Kristiansen, Ingebrigt Sylt. The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & medicinal chemistry. vol 16. issue 20. 2008-12-15. PMID:18812261. |
in the present work, we are studying the inhibition of the serotonin transporter protein by a series of buspirone analogues by molecular modelling and by experimental affinity measurements. |
2008-12-15 |
2023-08-12 |
Not clear |
| L W Lim, Y Temel, T Sesia, R Vlamings, V Visser-Vandewalle, H W M Steinbusch, A Bloklan. Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18588948. |
several findings have demonstrated that the properties of buspirone (a 5-ht(1a) partial agonist) would function as either anxiolytic or panicolytic in both clinical and laboratory animal research. |
2008-11-05 |
2023-08-12 |
rat |
| S O'Mahony, A S B Chua, E M M Quigley, G Clarke, F Shanahan, P W N Keeling, T G Dina. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 6. 2008-10-13. PMID:18194152. |
the aims of this study were to determine if buspirone stimulates prolactin release through the 5-hydroxytryptamine (5ht)1a receptor and whether this response is altered in patients with ibs and in the rat maternal separation model. |
2008-10-13 |
2023-08-12 |
rat |
| R J O'Sullivan, I G Brown, M P Pende. Apneusis responding to buspirone in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 14. issue 5. 2008-09-11. PMID:18424481. |
here we report on a patient with ms who developed episodic apneusis which responded to treatment with buspirone, a serotonin type 1a receptor agonist. |
2008-09-11 |
2023-08-12 |
Not clear |
| Tetsuya Takahashi, Hironori Mitsuya, Tetsuhito Murata, Junichi Murayama, Yuji Wad. Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder. Sleep medicine. vol 9. issue 3. 2008-08-29. PMID:17644482. |
we encountered a patient with idiopathic rbd that dramatically improved with selective serotonin reuptake inhibitors (ssris) and deteriorated with a 5-ht1a partial agonist, tandospirone. |
2008-08-29 |
2023-08-12 |
Not clear |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
the objective of the present investigation was to assess open field (of) activity and the brain regional 5-ht(1a) receptor densities of the sham operated (shx) and obx rats treated with saline (shx-sal, obx-sal), and either 10 mg/(kg day) (shx-b10, obx-b10) or 20 mg/(kg day) (shx-b20, obx-b20) of buspirone for 14 days, delivered by a subcutaneous osmotic minipump. |
2008-07-10 |
2023-08-12 |
human |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
in the obx rats, only the 14-day treatment with 20mg/(kgday) of buspirone normalized the elevated of activity, the same dose shown previously to be needed for the normalization of the regional 5-ht synthesis. |
2008-07-10 |
2023-08-12 |
human |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
the 14-day treatment with either 10 or 20 mg/(kg day) of buspirone reduced the 5-ht(1a) receptors in most brain regions of the shx rats, without an obvious dose-dependent effect of the buspirone. |
2008-07-10 |
2023-08-12 |
human |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
the comparison between the obx-b20 and control (shx-b20) rats suggests that the buspirone treatment resulted in a regional balance in the 5-ht(1a) sites. |
2008-07-10 |
2023-08-12 |
human |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
a dose dependent reduction in the density of 5-ht(1a) sites was observed in the sham rats, but the buspirone treatment had very little effect on the density of the 5-ht(1a) receptors in the obx rats. |
2008-07-10 |
2023-08-12 |
human |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
from these observations, we conclude that the antidepressant effects of buspirone in the obx rat model of depression are likely mediated through the fine tuning of the regional imbalance of 5-ht(1a) receptors with even increases of about 20% in some limbic regions. |
2008-07-10 |
2023-08-12 |
human |
| José Gazulla, Pedro Modreg. Buspirone and serotonin in spinocerebellar ataxia. Journal of the neurological sciences. vol 268. issue 1-2. 2008-07-02. PMID:18222483. |
buspirone and serotonin in spinocerebellar ataxia. |
2008-07-02 |
2023-08-12 |
Not clear |
| Robert J Bielski, Lynn Cunningham, Joseph P Horrigan, Peter D Londborg, Ward T Smith, Kenneth Weis. Gepirone extended-release in the treatment of adult outpatients with major depressive disorder: a double-blind, randomized, placebo-controlled, parallel-group study. The Journal of clinical psychiatry. vol 69. issue 4. 2008-06-16. PMID:18373383. |
to evaluate the efficacy and tolerability of extended-release gepirone (gepirone-er), a 5-ht(1a) agonist, versus placebo in the treatment of adult outpatients with major depressive disorder (mdd). |
2008-06-16 |
2023-08-12 |
Not clear |
| A G Dhavalshankh, S A Jadhav, R V Gaikwad, R K Gaonkar, V M Thorat, J J Balsar. Effects of buspirone on dopamine dependent behaviours in rats. Indian journal of physiology and pharmacology. vol 51. issue 4. 2008-06-05. PMID:18476392. |
buspirone, a partial agonist of 5-hydroxytryptamine autoreceptors, selectively blocks presynaptic nigrostriatal d2 dopamine (da) autoreceptors. |
2008-06-05 |
2023-08-12 |
rat |
| Peter Heusler, Adrian Newman-Tancredi, Timothé Loock, Didier Cussa. Antipsychotics differ in their ability to internalise human dopamine D2S and human serotonin 5-HT1A receptors in HEK293 cells. European journal of pharmacology. vol 581. issue 1-2. 2008-05-23. PMID:18190908. |
at the ha-h5-ht(1a) receptor, serotonin, (+)-8-hydroxy-2-(di-n-propylamino)tetralin [(+)-8-oh-dpat] and sarizotan were full agonists, buspirone acted as partial agonist. |
2008-05-23 |
2023-08-12 |
human |
| Machiko Matsumoto, Hiroko Togashi, Kohtaro Konno, Hiroyo Koseki, Riki Hirata, Takeshi Izumi, Taku Yamaguchi, Mitsuhiro Yoshiok. Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats. Pharmacology, biochemistry, and behavior. vol 89. issue 3. 2008-05-20. PMID:18262260. |
repeated treatment with the serotonin 5-hydroxytryptamine-1a (5-ht(1a)) receptor agonist tandospirone (1 mg/kg, i.p., for 4 days) prevented the expression of freezing behavior in 3wfs, whereas diazepam treatment (1 mg/kg, i.p., for 4 days) in 3wfs did not. |
2008-05-20 |
2023-08-12 |
rat |
| Jakob J Lopez, Mark Lorc. Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes. The Journal of biological chemistry. vol 283. issue 12. 2008-05-12. PMID:18187421. |
magic angle spinning (mas) nmr has been used to investigate the location and orientation of five serotonin receptor 1a agonists (serotonin, buspirone, quipazine, 8-oh-dpat, and ly-163,165) in single component model lipid and brain lipid membranes. |
2008-05-12 |
2023-08-12 |
Not clear |