| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
these results suggest that normalization (reduction to the level found in the shx-sal rats) of 5-ht synthesis in the obx requires a greater dose of buspirone (20 mg/(kg day)) than that needed to produce a desensitization of the 5-ht1a receptors in the sham operated rats (10 mg/(kg day)). |
2006-06-01 |
2023-08-12 |
rat |
| Sietse F de Boer, Jaap M Koolhaa. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. European journal of pharmacology. vol 526. issue 1-3. 2006-05-25. PMID:16310183. |
it was found that, similar to other prototypical full and partial 5-ht(1a) and/or 5-ht(1b) receptor agonists like repinotan, 8-ohdpat, ipsapirone, buspirone, alnespirone, eltoprazine, cgs-12066b and cp-93129, also s-15535 very effectively reduced offensive aggressive behavior. |
2006-05-25 |
2023-08-12 |
rat |
| Erum Shireen, Darakhshan J Halee. Motor effects of buspirone: Relationship with dopamine and serotonin in the striatum. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 15. issue 12. 2006-05-25. PMID:16398963. |
motor effects of buspirone: relationship with dopamine and serotonin in the striatum. |
2006-05-25 |
2023-08-12 |
rat |
| E Syvälahti, J Penttilä, H Majasuo, E-P Pälvimäki, A Laakso, J Hietal. Combined treatment with citalopram and buspirone: effects on serotonin 5-HT2A and 5-HT2C receptors in the rat brain. Pharmacopsychiatry. vol 39. issue 1. 2006-03-29. PMID:16453246. |
combined treatment with citalopram and buspirone: effects on serotonin 5-ht2a and 5-ht2c receptors in the rat brain. |
2006-03-29 |
2023-08-12 |
rat |
| Sue J Wilson, Jayne E Bailey, Ann S Rich, Jon Nash, Mariona Adrover, A Tournoux, David J Nut. The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Journal of psychopharmacology (Oxford, England). vol 19. issue 6. 2006-02-09. PMID:16272182. |
the partial agonist buspirone has a rem (rapid eye movement) suppressing effect on human sleep probably via a 5ht(1a) receptor in the pontine area. |
2006-02-09 |
2023-08-12 |
human |
| Sue J Wilson, Jayne E Bailey, Ann S Rich, Jon Nash, Mariona Adrover, A Tournoux, David J Nut. The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Journal of psychopharmacology (Oxford, England). vol 19. issue 6. 2006-02-09. PMID:16272182. |
eptapirone is a new 5ht(1a) agonist with a greater intrinsic effect than buspirone. |
2006-02-09 |
2023-08-12 |
human |
| Sue J Wilson, Jayne E Bailey, Ann S Rich, Jon Nash, Mariona Adrover, A Tournoux, David J Nut. The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Journal of psychopharmacology (Oxford, England). vol 19. issue 6. 2006-02-09. PMID:16272182. |
rem sleep effects were greatest after evening eptapirone, suggesting a greater effect on central serotonin receptors than that of buspirone. |
2006-02-09 |
2023-08-12 |
human |
| Sabela Fernández-Pérez, David M Pache, Robert D E Sewel. Co-administration of fluoxetine and WAY100635 improves short-term memory function. European journal of pharmacology. vol 522. issue 1-3. 2006-01-10. PMID:16214127. |
the aim of this study was to determine whether the action of the antidepressant fluoxetine or the anxiolytic buspirone could be modified by specific 5-hydroxytriptamine (5-ht(1a)) receptor blockade in a short-term memory paradigm. |
2006-01-10 |
2023-08-12 |
rat |
| Sabela Fernández-Pérez, David M Pache, Robert D E Sewel. Co-administration of fluoxetine and WAY100635 improves short-term memory function. European journal of pharmacology. vol 522. issue 1-3. 2006-01-10. PMID:16214127. |
way100635, a selective 5-ht(1a) receptor antagonist (0.15 mg/kg), was administered 15 min before either the selective serotonin reuptake inhibitor fluoxetine (3 mg/kg), or the partial 5-ht(1a) receptor agonist and dopamine d2 receptor antagonist, buspirone (0.3 mg/kg). |
2006-01-10 |
2023-08-12 |
rat |
| J M Zanoveli, R L Nogueira, H Zangross. Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety. Behavioural pharmacology. vol 16. issue 7. 2005-11-30. PMID:16170231. |
the effects of these 5-ht agonists in the dpag were also investigated in animals chronically injected with buspirone, a drug clinically effective in treating gad, but not pd. |
2005-11-30 |
2023-08-12 |
rat |
| Machiko Matsumoto, Kasane Higuchi, Hiroko Togashi, Hiroyo Koseki, Taku Yamaguchi, Manabu Kanno, Mitsuhiro Yoshiok. Early postnatal stress alters the 5-HTergic modulation to emotional stress at postadolescent periods of rats. Hippocampus. vol 15. issue 6. 2005-10-13. PMID:15999341. |
the 5-ht(1a) receptor agonist tandospirone (10 mg/kg body wt, i.p.) |
2005-10-13 |
2023-08-12 |
rat |
| M Babette Fontenot, E Eugene Padgett, Amy M Dupuy, Cheryl R Lynch, Paolo B De Petrillo, J Dee Higle. The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comparative medicine. vol 55. issue 1. 2005-09-16. PMID:15766212. |
the effects of two serotonergic agents--fluoxetine, a serotonin (5-ht) reuptake inhibitor, and buspirone, a 5-ht 1a agonist--on rates of self-injurious and stereotypic behavior were examined in 15 adult male macaca mulatta. |
2005-09-16 |
2023-08-12 |
monkey |
| Michael Brüss, Arevat Kostanian, Heinz Bönisch, Manfred Göther. The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction. Pharmacogenetics and genomics. vol 15. issue 4. 2005-09-13. PMID:15864118. |
the ability of 5-ht to stimulate [35s]gtpgammas binding (a measure of g protein coupling) to the var receptor and of the agonists 5-ht, buspirone and urapidil to inhibit forskolin-stimulated camp accumulation in hek293 cells expressing the var receptor was decreased by 60-90%. |
2005-09-13 |
2023-08-12 |
human |
| R I Ohlsen, L S Pilowsk. The place of partial agonism in psychiatry: recent developments. Journal of psychopharmacology (Oxford, England). vol 19. issue 4. 2005-09-08. PMID:15982997. |
the anxiolytic buspirone shows partial agonism at 5-ht(1a) receptors, and this seems to provide anxioselective effects, without inducing extrapyramidal side-effects, convulsions, tolerance or withdrawal reactions. |
2005-09-08 |
2023-08-12 |
Not clear |
| Yumi Sugimoto, Nozomu Takashima, Toshiko Noma, Jun Yamad. Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). Biological & pharmaceutical bulletin. vol 28. issue 4. 2005-08-26. PMID:15802819. |
inhibitory effects of the 5-ht(1a) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-pp). |
2005-08-26 |
2023-08-12 |
mouse |
| G K Pal, N Kannan, Pravati Pa. Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian journal of physiology and pharmacology. vol 48. issue 4. 2005-07-22. PMID:15907052. |
in the present study, serotonin hydrochloride, buspirone (the serotonin 5-ht1a agonist) and ondensetron (the 5ht3 antagonist) were injected into nucleus caudatus through stereotaxically implanted cannulae in three different dosages (1, 2 and 5 microg) and their effects on 24 h food and water intake, and body weight were recorded. |
2005-07-22 |
2023-08-12 |
rat |
| Nicole R Sullivan, James W Crane, Katerina J Damjanoska, Gonzalo A Carrasco, Deborah N D'Souza, Francisca Garcia, Louis D Van de Ka. Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 1. 2005-07-11. PMID:15655673. |
tandospirone, an azapirone, is a selective serotonin(1a) (5-ht(1a)) receptor agonist. |
2005-07-11 |
2023-08-12 |
rat |
| Nicole R Sullivan, James W Crane, Katerina J Damjanoska, Gonzalo A Carrasco, Deborah N D'Souza, Francisca Garcia, Louis D Van de Ka. Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 1. 2005-07-11. PMID:15655673. |
pretreatment with the specific 5-ht(1a) receptor antagonist way 100,635 (0.3 mg/kg, s.c.) completely blocked the effects of tandospirone on plasma levels of oxytocin, acth, and corticosterone but shifted the dose-response curve for prolactin to the right. |
2005-07-11 |
2023-08-12 |
rat |
| Yuji Odagaki, Ryoichi Toyoshima, Toshio Yamauch. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England). vol 19. issue 3. 2005-06-27. PMID:15888508. |
the intrinsic activities of both compounds were higher than those of tandospirone and buspirone, which are clinically effective anxiolytics with well-known 5-ht(1a) partial agonist properties. |
2005-06-27 |
2023-08-12 |
human |
| Yuji Odagaki, Ryoichi Toyoshima, Toshio Yamauch. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England). vol 19. issue 3. 2005-06-27. PMID:15888508. |
when considering the implications of 5-ht(1a) receptors in anxiety and/or depression, as well as the clinical effectiveness of azapirone anxiolytics with partial 5-ht(1a) receptor agonist properties such as buspirone, it is possible that the agonist effects on 5-ht(1a) receptors of trazodone and its active metabolite m-cpp presented in this study contribute, at least in part, to the clinical efficacy of the atypical antidepressant trazodone. |
2005-06-27 |
2023-08-12 |
human |